Clinical trials: OA Knee Pain
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Knee Osteoarthritis (Knee OA)
To Assess the Effect of 336 Days Exposure of Paractin® on Pain & Disease Progression in Patients Suffering From Osteoarthritis of Knee Joint.
Sponsor aimed to study hydroalcoholic extract of Andrographis paniculata (for its effect on OA disease progression in OA patients with moderate to severe knee OA.
- Trial name
- NCT04833946
- Testing
- Andrographis paniculata [150 mg], Microcrystalline Cellulose (MCC)
- Where
- 5 sites in India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Total Knee Replacement
Innovative Gait Training for People With Knee Osteoarthritis Using Dual Belt Treadmill
Knee osteoarthritis (OA) is the most common form of arthritis and is the leading cause of chronic musculoskeletal pain and functional disability. Gait assessment is essential for the rehabilitation of people with knee OA.
- Trial name
- NCT05958212
- Testing
- Gait training program, Conventional training only
- Where
- Hong Kong
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis, Knee, Pain
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis
Osteoarthritis (OA) in the knee is characterized by chronic inflammatory pain that is not necessarily related to the amount of joint damage.
- Conditions
- Osteoarthritis, Knee, Pain, Physical Activity, Mitochondrial Pathology
- Trial name
- NCT03344913
- Testing
- Walking
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Osteoarthritis
Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients
The Collaborative Lifestyle Intervention Program in Knee OsteoArthritis Patients (CLIP-OA) compares a novel community-based exercise and dietary weight loss program to the Arthritis Foundation's Walk with Ease intervention on…
- Trial name
- CLIP-OA (NCT02835326)
- Testing
- Exercise and Dietary Weight Loss, Walk with Ease
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Osteoarthritis, Knee
Radiofrequency Ablation on Pain Relief of Knee Osteoarthritis
Introduction Osteoarthritis (OA) is a chronic, progressive disease with high disability and teratogenicity in the joints. Deterioration of the articular cartilage is the main problem associated with osteoarthritis, which…
- Trial name
- NCT05050396
- Testing
- Cooled versus thermocoagulant Radiofrequency Ablation in pain relief of knee osteoarthritis
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis, Knee, Orthopedic Disorder
Gait, Pain and Physical Activity After HTO
This study aims to investigate the relationship between pain, gait and activity intensity in HTO patients that are healed and have had their fixation plate removed.
- Trial name
- NCT04619550
- Testing
- High tibial osteotomy
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Winchester
Knee Osteoarthritis
Effect of Antigravity Treadmill in Knee Osteoarthritis (AGTreadmill)
To date, the anti-gravity treadmill, as a representative method of lower body positive pressure treadmills, has been rarely reported for knee osteoarthritis rehabilitation.
- Trial name
- AGTreadmill (NCT06347692)
- Testing
- antigravity treadmill, physical therapy exercise program
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prince Sattam Bin Abdulaziz University
Osteoarthritis, Knee Osteoarthritis
Osteoarthritis Initiative (OAI): A Knee Health Study
Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the…
- Trial name
- NCT00080171
- Where
- 5 sites in United States
- Volunteers
- 4,796 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Osteoarthritis (OA) of the Knee, Fear of Needles
Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?
This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence…
- Trial name
- NCT06865170
- Testing
- 25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Knee Pain Chronic, Knee Osteoarthritis
Prevention, Management and Rehabilitation of Knee Osteoarthritis at the Workplace
The goal of this intervention study is to assess the effect of blood flow restricted (BFR) exercise integrated into the daily work tasks among hospital workers with or at increased risk of chronic knee pain.
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Knee Discomfort
- Trial name
- NCT05822401
- Testing
- Blood flow restriction (BFR), Usual care (control)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Osteoarthritis, Knee
Effects of Central Sensitization on Response to Conventional Physical Therapy in Patients With Knee Osteoarthritis
The aim of this study was to investigate the relationship between central sensitization (CS) and poor response to conventional physical therapy in patients with knee osteoarthritis (OA) by evaluating clinical parameters of pain…
- Trial name
- NCT05518097
- Testing
- Conventional physical therapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Knee
Pain Relief Effect of Low-intensity Continuous Ultrasound Stimulator for Knee Arthritis
The goal of this clinical trial is to test low-intensity continuous ultrasound stimulator(LICUS) for patients suffering from knee arthritis. it aims to evaluate the pain relief effect of LICUS.
- Trial name
- NCT05657535
- Testing
- Low-intensity continuous ultrasound stimulator
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kyu Jae Lee
Osteoarthritis, Knee, Rheumatoid Arthritis
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis
Osteoarthritis (OA) is a condition affecting the whole joint and is a major cause of pain and disability worldwide. Although OA is very common, the initial steps which lead to the development of pain and tissue damage are not…
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- ARPAIN (NCT03533569)
- Testing
- Intra-articular corticosteroid injection
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Knee Osteoarthritis, Pain
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans.
- Conditions
- Knee Osteoarthritis, Pain, Depression
- Trial name
- DRIVE (NCT07649291)
- Testing
- Exercise, Duloxetine, PT referral
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement in Knee Osteoarthritis
This study aims to compare the effects of aquatic and land-based Mulligan mobilization with movement in individuals with knee osteoarthritis, with particular focus on their impact on pain and functional outcomes.
- Trial name
- NCT07484529
- Testing
- Aquatic Mobilization with Movement, Land Mobilization with Movement
- Where
- Pakistan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Knee Osteoarthritis
Knee Pain Phenotypes in the Community Study
The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over.
- Trial name
- NCT02098070
- Where
- United Kingdom
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Knee Osteoarthritis
Chronic Knee Pain Study
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement.
- Trial name
- JRPIT (NCT00776932)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh