Clinical trials: OCD, active
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Obsessive-compulsive Disorders and Symptoms, Obsessive-Compulsive Disorder
Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a highly disabling psychiatric illness, characterized by obsessional thoughts that cause patients to perform time-consuming and distressing compulsive rituals.
- Trial name
- RCT_TOC_16 (NCT03677947)
- Testing
- Exposure and response prevention, Inference-based cognitive therapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Anorexia Nervosa
Identifying Networks Underlying Compulsivity in Anorexia Nervosa for Targeting With Neuromodulation
Transcranial Magnetic Stimulation (TMS) is approved by the Food and Drug Administration (FDA) for the treatment of refractory Major Depressive Disorder (MDD) and obsessive-compulsive disorder (OCD).
- Trial name
- NCT06138782
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Obsessive-Compulsive Disorder
Cortical Stimulation to Treat Obsessive Compulsive Disorder
The purpose of this study is to identify abnormal brain signals associated with Obsessive Compulsive Disorder (OCD) and psychiatric symptoms and to investigate novel therapeutic stimulation sites.
- Trial name
- NCT04958096
- Testing
- Standard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrew Moses Lee, MD, PhD
Obsessive-Compulsive Disorder, Social Anxiety Disorder
Neurobiological Markers of Treatment Response for Anxiety and OCD
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided.
- Conditions
- Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05663489
- Testing
- Bergen 4-Day Treatment (B4DT)
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Obsessive-Compulsive Disorder (OCD)
DBS for Treatment-resistant Obsessive-compulsive Disorder
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) implantation targeting the anteromedial region of subthalamic nucleus (amSTN), or nucleus accumbens (NAc), or bed nucleus of the stria…
- Trial name
- NCT06360991
- Testing
- Deep brain stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Treatment Resistant Depression, Major Depressive Episode
University of Iowa Interventional Psychiatry Service Patient Registry
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD).
- Conditions
- Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder
- Trial name
- NCT04480918
- Testing
- Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mark Niciu
Obsessive-Compulsive Disorder, Tic Disorder
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis
This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics…
- Trial name
- NCT06754319
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Obsessive - Compulsive Disorder
tDCS and Symptom Provocation in Treatment-Resistant OCD
The goal of this clinical trial is to learn if symptom provocation before transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD) patients.
- Trial name
- PPS-TDCSTOC (NCT07429500)
- Testing
- tDCS session, symptom provocation
- Where
- 6 sites in France
- Volunteers
- 178 people
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive Compulsive Behavior
TMS + Exposure Therapy for Pediatric OCD: Second Phase
The goal of this clinical trial is to test transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD).
- Trial name
- NExT (NCT07859683)
- Testing
- Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area, Exposure with Response Prevention
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Bradley Hospital
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Obsessive Compulsive Disorder, Body Dysmorphic Disorder
Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
To examine the effectiveness and clinical care outcomes of cognitive-behavioral therapy interventions at Massachusetts General Hospital (MGH).
- Conditions
- Obsessive Compulsive Disorder, Body Dysmorphic Disorder, Tourette Syndrome, Trichotillomania
- Trial name
- NCT01075672
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
OCD, Obsessive-Compulsive Disorder
Locating Biomarkers in OCD Through Behavioral Tasks
Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information…
- Trial name
- NCT03313622
- Testing
- Beads Task, PROVOC Tasks
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Obsessive - Compulsive Disorder
Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD
The goal of this clinical study is to investigate the neural mechanisms of abnormal sensory phenomena in patients with Obsessive-Compulsive Disorder and to evaluate whether modulation of the insula-supplementary motor area…
- Trial name
- NCT07480408
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD).
- Trial name
- NCT06660225
- Testing
- Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nader Pouratian
Obsessive-Compulsive Disorder
Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation
This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited…
- Trial name
- NCT07065669
- Testing
- Dorsal medial Prefrontal Cortex intermittent theta burst stimulation, cTBS to ROFC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Obsessive-compulsive Disorder
Clinical Outcomes in Pediatric Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder (OCD) is a common neuropsychiatric illness beginning in childhood. Effective OCD treatments include cognitive-behaviour therapy (CBT) and medications but access to treatment is difficult and does not…
- Trial name
- NCT01635569
- Testing
- Group-based family cognitive-behavioural therapy, Waitlist
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Obsessive - Compulsive Disorder
Feasibility and Efficacy Trial of a Culturally Adapted Guided Self-Help CBT Manual for OCD
This randomised controlled trial (RCT) aims to assess the feasibility, acceptability, and preliminary efficacy of a culturally adapted, guided self-help cognitive behaviour therapy (CBT) manual specifically designed for…
- Trial name
- NCT07239401
- Testing
- Culturally adapted Guided Self-Help OCD Manual
- Volunteers
- 108 people
- Sponsor
- Pakistan Association of Cognitive Therapists
Obsessive Compulsive Disorder
Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
This study involves the use of the Medtronic PC+S deep brain stimulation for the treatment of intractable OCD.
- Trial name
- NCT03184454
- Testing
- Medtronic Percept Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Hoarding Disorder
Neural Mechanisms of Decision Making in Hoarding Disorder
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.
- Trial name
- LOSS (NCT03487224)
- Testing
- MRI with fMRI frequency
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University