Clinical trials: OHSS
Infertility, Ovarian Hyperstimulation Syndrome
Short Versus Long Protocol for IVF and IVF+ICSI
Purpose: Comparing a GnRH agonist and an antagonist protocol for IVF/ICSI with regard to 1. frequency of ovarian hyperstimulation syndrome (OHSS) (1. outcome measure) 2. quality of life (2. outcome measure) 3. live birth rate (2.
- Conditions
- Infertility, Ovarian Hyperstimulation Syndrome, Quality of Life, Live Birth
- Trial name
- KvL (NCT00756028)
- Testing
- Patients receiving short protocol IVF/ICSI-treatment., Long protocol
- Where
- 2 sites in Denmark
- Volunteers
- 1,099 people
- Sponsor
- Peter Hornnes, MD, DMSc
Ovarian Hyperstimulation Syndrome, Frozen-thawed Embryo Transfers
Association Between Live Birth Rate and Serum Progesterone During Hormonal Replacement Therapy
Nowadays, frozen-thawed embryo transfers (FET) are expending. This practice avoids risk of ovarian hyperstimulation syndrome (OHSS), as well as allowing better synchronization between endometrium and embryo, which is fundamental…
- Trial name
- PROGEVOL (NCT05588635)
- Testing
- Identification of predictive factors
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Infertility
Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist
The purpose of this study is to see whether patients triggered with only human Chorion Gonadotropin (hCG) have higher number of Metaphase II oocytes (MII) and implantation rate than patients triggered with hCG combined with…
- Trial name
- NCT01607203
- Testing
- Decapeptyl Daily, pregnyl
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Ovarian Hyperstimulation Syndrome
Efficacy and Safety of Dexamethasone Prevention for Patients of Ovarian Hyperstimulation Syndrome
This prospective, randomized, controlled clinical trial will evaluate the effect and security of dexamethasone prevention for Patients of Ovarian Hyperstimulation Syndrome.
- Trial name
- NCT02846493
- Testing
- bromocriptine, dexamethasone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Infertility
Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome
The purpose of this study is to compare the effect of oral Diosmin to oral Cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in high-risk women underwent intracytoplasmic sperm injection (ICSI).
- Trial name
- infertility (NCT02134249)
- Testing
- Diosmin, Cabergoline
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
In Vitro Fertilization
Corifollitropin Alfa Application in PCOS Patients
Corifollitropin alfa, single dose administered sustains multiple follicular development for 7 days. However, It may induce ovarian hyperstimulation syndrome (OHSS), especially in high responder women such as patients of…
- Trial name
- NCT02215135
- Testing
- Corifollitropin alfa
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
OHSS
Cabergoline Versus Calcium Gluconate Infusion in the Prevention of Ovarian Hyperstimulation Syndrome
The aim of this study is to compare the efficacy of calcium gluconate infusion versus cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in patients pretreated with GnRH agonist long protocol who are at…
- Trial name
- NCT02875587
- Testing
- Cabergoline, Calcium gluconate
- Where
- 2 sites in Egypt
- Volunteers
- 170 people
- Sponsor
- Aljazeera Hospital
Ovarian Hyperstimulation Syndrome, Hypercoagulability
Ovarian Hyperstimulation Syndrome in Patients Triggered by GnRH Agonist for Excessive Follicular Response
In the literature, the risk of moderate to severe OHSS is 3 to 6% and reaches 31% in high risk populations 9 days after oocyte triggering with hCG.
- Trial name
- COAGO (NCT02701452)
- Testing
- COAGO
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Infertility and at High Risk of OHSS
Repeated Injection of GnRH Agonist to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022241
- Testing
- triptorelin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chenshiling
Ovarian Hyperstimulation Syndrome
Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS
The aim of this work is to study the value of GnRH antagonist subcutaneous administration as an alternative to coasting in prevention of severe OHSS and its impact on embryos quality \& the outcome of ICSI.
- Trial name
- NCT03996434
- Testing
- Gonadotropin, Antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- ClinAmygate
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome
This study is a randomized controlled clinical trial to compare the pregnancy outcomes of mild and minimal stimulation in infertile women with polycystic ovarian syndrome.
- Trial name
- NCT03876145
- Testing
- Minimal ovarian stimulation
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Pregnancy Early, Miscarriage
Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
Gonadotropin Releasing Hormone agonist (GnRHa) triggering is used as an alternative to human chorionic gonadotropin (hCG) in GnRH antagonist protocol to eliminate the risk of ovarian hyperstimulation syndrome (OHSS).
- Conditions
- Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome
- Trial name
- NCT04797338
- Testing
- Synarel, 0.2 Mg/Inh Nasal Spray, Estrofem, Utrogestan
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
OHSS
Cabergoline Versus GnRH Antagonist Rescue and Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome
The aim of study is to compare the efficacy of GnRH antagonist rescue combined with cabergoline with cabergoline in the prevention of ovarian hyperstimulation syndrome in high risk patients undergoing ovarian stimulation for…
- Trial name
- NCT02461875
- Testing
- Cabergoline, GnRH antagonist rescue & cabergoline
- Where
- Egypt
- Volunteers
- 236 people
- Sponsor
- Aljazeera Hospital
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
In Vitro Maturation of Immature Oocytes
The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as…
- Trial name
- NCT00480337
- Testing
- In Vitro Maturation of immature oocytes
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
IVF Cycle, Ovarian Stimulation
Efficacy and Safety of Medication Used to Stimulate Ovulation
Individuals undergoing In Vitro Fertilization must undergo controlled ovarian hyperstimulation (COH) to produce enough quality eggs for fertility treatment.
- Conditions
- IVF Cycle, Ovarian Stimulation, Egg Retrieval, Pregnancy
- Trial name
- NCT02715336
- Testing
- Ovulation induction with hCG and Lupron (GnRH agonist)
- Where
- Canada
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Create Fertility Center
Ovarian Hyperstimulation Syndrome
Double GnRH Antagonist Daily Dose in Hyperresponding IVF/ICSI Cycles May Prevent the OHSS
The possibility to prevent the early ovarian hyperstimulation syndrome (OHSS) by doubling the daily dose of GnRH-antagonist in women stimulated with the antagonist protocol who are at risk for OHSS was evaluated.
- Trial name
- NCT01477970
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Iakentro Fertility Centre
Multifollicular Stimulation
An Observational Study to Compare the Dose of Gonal-fTM FbM Prescribed by the Doctor With the Recommendation of the Dose Calculator Consort and to Evaluate the Ease of Use of Pre-filled Pen of Gonal-fTM FbM Pen
This is a prospective, observational and multicentric study to compare the Gonal-f FbM (filled by mass) dose prescribed by the doctor with the Gonal-f FbM dose determined by the CONSORT (Consistency in r-FSH Starting doses for…
- Trial name
- NCT01080729
- Testing
- Recombinant-follicle stimulating hormone (r-FSH)
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ovarian Hyperstimulation Syndrome
Tolerability of Quinagolide in a Dose-titration Regimen in Oocyte Donors at Risk of Developing Ovarian Hyperstimulation Syndrome
Assess the tolerability of quinagolide 200 μg/day in a dose-titration regimen in oocyte donors undergoing controlled ovarian hyperstimulation and at risk of developing OHSS Secondary Objectives Estimate the effects of a…
- Trial name
- NCT00665041
- Testing
- Quinagolide
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin
GnRH Antagonist for Treatment of Early Ovarian Hyperstimulation Syndrome
The aim of this study is to analyze the effectiveness of GnRh antagonist in the treatment of early ovarian hyperstimulation syndrome.
- Conditions
- Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin, Oocyte Maturation
- Trial name
- NCT01268761
- Testing
- GnRH antagonist (Cetrorelix)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Ovarian Hyperstimulation Syndrome
Study of Serum Levels of Oxidative Stress Markers in Ovarian Hyperstimulation Patients
The aim of the study is to determine serum oxidative stress status by ischemia modified albumin (IMA), total antioxidant capacity (TAC), total oxidative capacity (TOS), oxidative stress capacity (OSI), and serum malondialdehyde…
- Trial name
- NCT02202278
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Karadeniz Technical University