Clinical trials: Obesity, Overweight
Adiposity, Fatty Liver
GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease
There is evidence that alcoholic beverage consumption significantly interacts with food energy intake. Furthermore, there is accumulating evidence showing independent, combined, and modifying effects of alcohol and metabolic…
- Conditions
- Adiposity, Fatty Liver, Alcohol Use Disorder
- Trial name
- GLP-1 RA (NCT06546384)
- Testing
- Semaglutide, Weight reduction recommendations (nutritional and exercise)
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Weight Loss, Metabolic Syndrome
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
The use of continuous glucose monitoring (CGM) in earlier data has inspired behavioral changes leading to improved adherence to an exercise plan in individuals and eating habits in people with diabetes.
- Conditions
- Weight Loss, Metabolic Syndrome, Diabetes Mellitus, Type 2, Central Obesity
- Trial name
- NCT05874635
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Visceral Obesity
The Effects of Increased Fiber Diet Consumption on Outcomes of Subjects With Visceral Obesity
The investigators propose to undertake a controlled dietary intervention study in UAE subjects with visceral obesity to examine the feasibility of a diet rich in fruits, vegetables and/or whole-grain fiber in the UAE population.
- Trial name
- NCT03363542
- Testing
- fruits, vegetables and/or whole grain high fiber rich diet
- Where
- United Arab Emirates
- Volunteers
- 332 people
- Sponsor
- United Arab Emirates University
Gene Abnormality
Endometrial Heparin-binding Epidermal Growth Factor Expression
Women with PCOS comprise a majority of fertility clinic attendees. Unfortunately, a high failure rate following fertility treatment was observed especially in obese women due to implantation failure.
- Trial name
- NCT04175002
- Testing
- utrogestan
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Type 2 Diabetes Mellitus, Obesity
Silastic Ring Gastric Bypass Versus Sleeve Gastrectomy for Type 2 Diabetes Mellitus in Obese Patients
Type 2 diabetes (T2DM) and obesity are becoming increasingly common in New Zealand (NZ) and worldwide. Both are associated with a risk of early mortality (death).
- Trial name
- NCT01486680
- Testing
- Laparoscopic Silastic Ring Roux-en-Y Gastric Bypass, Laparoscopic Sleeve gastrectomy
- Where
- 2 sites in New Zealand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- North Shore Hospital, New Zealand
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Obesity, Insulin Resistance
Capsaicin Energy Expenditure and Glucose Metabolism
The aim of the study is to investigate the effects of capsaicin rich foods on resting energy expenditure and substrate oxidation.
- Trial name
- CAPS (NCT03859583)
- Testing
- Capsaicin, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Mason University
Healthy
A Phase 1 Single and Multiple-Dose Study of Aramchol in Healthy Male Volunteers
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Escalating Single and Multiple-Dose Study of Aramchol in Healthy Male Volunteers. Primary Objectives: 1.
- Trial name
- NCT00776841
- Testing
- Aramchol
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Galmed Medical Reserch
Obesity, Obesity, Morbid
Effectiveness of the Mediterranean Diet on Weight Loss After Endoscopic Bariatric Treatmen
All participants were weighed every week for 24 weeks, wearing light clothes to the nearest 0.1 kg, using a body composition analyzer.
- Trial name
- NCT04738656
- Testing
- Diet plan
- Volunteers
- 78 people
- Sponsor
- Universitat Politècnica de Catalunya
Healthy, Obese
Exercise Regulation of Human Adipose Tissue
The purpose of this study is to determine whether exercise training leads to changes in the white adipose tissue that are beneficial to the body's regulation of sugar and body weight.
- Conditions
- Healthy, Obese, Diabetes Mellitus, Type 2
- Trial name
- NCT03133156
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity
Respiratory and Exercise Responses by Body Roundness Index in Obesity
This observational study aims to evaluate respiratory performance and exercise responses according to Body Roundness Index (BRI) in individuals with obesity.
- Trial name
- NCT07595822
- Testing
- Observational
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Biruni University
Obesity
The AUDACITY Study (AllUrion Device in Adults With Clinical ObesITY)
The objective for this clinical study is to provide FDA with clinical evidence regarding the effectiveness and safety of the AGBS + moderate intensity lifestyle modification therapy program, indwell time of the AGBS inside the…
- Trial name
- AUDACITY (NCT05368259)
- Testing
- AGBS
- Where
- 17 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Allurion Technologies
Type 2 Diabetes, Obesity
Enhancement of Brown Adipose Tissue Function Via Chronic Pharmacological Treatment
Obesity is epidemic in Australia, and current preventative strategies have had limited success in alleviating this health crisis.
- Conditions
- Type 2 Diabetes, Obesity, Cardiovascular Disease
- Trial name
- NCT02236962
- Testing
- Ephedrine, pioglitazone
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity, Prehypertension
Vascular Dysfunction in Human Obesity Hypertension
The purpose of the study is to test the effects of blocking sympathetic nerve activity with a drug called clonidine on blood vessel function and muscle nerve activity in adults who are obese and have high blood pressure.
- Conditions
- Obesity, Prehypertension, Hypertension
- Trial name
- VANISH (NCT01983462)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Overweight and Obesity
Early Detection of Myocardial Work Impairment in Obesity II(EARLY-MYO-OBESITY-II)
This prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.
- Trial name
- NCT04933188
- Testing
- Myocardial work was estimated from left ventricular pressure-strain loop derived from speckle tracking echocardiography and non-invasive brachial artery cuff pressure
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Overweight and Obesity
Translating Neuroscience to Population Health
The current study will examine the relationship between brain responses and a guided imagery exercise in overweight and obese individuals.
- Trial name
- NCT03976427
- Testing
- Guided Imagery
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Diabetes Mellitus, Type 2, Obesity
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function
Novo Nordisk is developing the study medicine NNC0487-0111 to treat people living with type 2 diabetes and/or people living with overweight or obesity.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Overweight
- Trial name
- NCT06559527
- Testing
- NNC0487-0111
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Obesity
Characterization of Dyslipidemia in Adolescent Obesity
The primary objective of this pilot study is to characterize the profile of lipoprotein, inflammatory, and metabolic markers of cardiovascular disease in obese adolescents as compared to normal-weight age-matched controls.
- Trial name
- NCT01988454
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Health Diagnostic Laboratory, Inc.
Healthy Volunteer, Obestity
Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism
Background: Many people in the United States are overweight or obese. This natural history study will look into how life events during childhood can impact eating behaviors and weight gain as adults.
- Trial name
- NCT06690294
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Growth, Infant Development
The Effect of Baby-Led Weaning and Traditional Complementary Feeding Education on Infant Development
The goal of this [type of study: clinical trial] is to compare compare the nutrition, development, obesity risk and anemia risk of the infant with the BLW method and TCF method given to the mothers of infants who have switched to…
- Conditions
- Growth, Infant Development, Complementary Feeding, Nutrition, Healthy
- Trial name
- NCT05771324
- Testing
- Baby-Led Weaning (BLW), Traditional Complementary Feeding (TCF)
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
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