Clinical trials: Obesity; Overweight
Obesity, Overweight
A Study to Investigate the Effect of a Low-fat Meal and Evening Dosing on KAI-7535 in Participants Living With Obesity or Overweight
The primary objective of this study is to evaluate the effect of a meal and evening dosing on the pharmacokinetics (PK) of KAI 7535 in healthy participants living with obesity or overweight.
- Trial name
- NCT07294898
- Testing
- KAI-7535
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kailera
Hypertension, Obesity & Overweight
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
Hypertension is the leading risk factor for death globally, affecting approximately 30% of adults in the United Kingdom. Obesity is also a serious and ongoing epidemic, with global obesity rates having more than tripled in men…
- Trial name
- SOLUTION-Pilot (NCT07364175)
- Testing
- Tirzepatide, Anti-Hypertensive medications
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Overweight, Obesity
A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight
This study will look at how well the new medicine CagriSema helps people living with excess body weight and type 2 diabetes losing weight. Participants will either get CagriSema or a dummy medicine.
- Conditions
- Overweight, Obesity, Type 2 Diabetes Mellitus
- Trial name
- REDEFINE 2 (NCT05394519)
- Testing
- Cagrilintide, Semaglutide
- Where
- 179 sites in United States, Austria and 11 more
- Volunteers
- 1,200 people
- Sponsor
- Novo Nordisk A/S
Obesity and Overweight, Insulin Resistance
New Mechanisms of Obesity
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition.
- Conditions
- Obesity and Overweight, Insulin Resistance, Obesity and Obesity-related Medical Conditions
- Trial name
- NMoO (NCT06768827)
- Testing
- Lactulose Oral Product
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Yale University
Obesity and Overweight
This Study Will Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of MET097 in Adult Participants With Overweight or Obesity
The goal of this Phase 1/2 clinical trial is to assess the safety, tolerability, pharmacokinetics, and efficacy of once-weekly subcutaneous injections of MET097 in otherwise healthy adults with overweight or obesity.
- Trial name
- NCT06857617
- Testing
- (Part C) MET097
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Metsera, a wholly owned subsidiary of Pfizer
Obesity and Overweight, Hypertriglyceridaemia
Comparison of Cardiometabolic Markers in Individuals With Hypertriglyceridemia With Low and High Weight Loss Responses to an Energy-restricted Diet
Total RNA is extracted from isolated white blood cells, and cDNA is synthesized from these samples. Subsequently, the expression levels of the SIRT1 and leptin receptor genes are determined through quantitative PCR.
- Trial name
- NCT07012226
- Testing
- Low-calorie diet
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Overweight, Overweight and Obesity
Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat.
- Conditions
- Overweight, Overweight and Obesity, Adiposity
- Trial name
- NCT07368777
- Testing
- Genotype-Based Dietary Counseling, Standard Dietary Counseling
- Where
- Greece
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Metropolitan College
Overweight and Obesity
Neuromuscular Balance Exercise Effects in Overweight and Obese Individuals
This randomized controlled study aims to evaluate the effects of adding neuromuscular balance exercises to exercise programs on functional capacity, balance, and physical fitness in individuals with obesity.
- Trial name
- NCT07372157
- Testing
- Aerobic and strength training, Neuromuscular balance exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
Overweight (BMI > 25), Obesity & Overweight
Gummy Candies With Maqui Berry
The goal of this clinical trial is to learn if Maqui berry gummy encapsulated (GMM) compared to non-encapsulated (GM) can improve glycemic response in overweight adults.
- Conditions
- Overweight (BMI > 25), Obesity & Overweight, Insulin Resistance Syndrome, Type 2 Diabetes
- Trial name
- MaquiGUM (NCT07373795)
- Testing
- GM, Control, GMM
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Gonzalo Jorquera, PhD
Menopause, Obesity and Overweight
Time-Restricted Eating in Menopause and HOrmone-sensitive Breast Cancers (TREMHO)
This study is aimed at women currently going through menopause, either as part of the natural process (physiological menopause), or following hormonal treatment for breast cancer.
- Trial name
- TREMHO (NCT06855784)
- Testing
- Time-Restricted Eating 16h/8h, Active Control
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- University Hospital, Geneva
Obesity & Overweight, Pediatric Obesity
Ultrasound Assessment of Tongue Characteristics in Children and Adolescents With Obesity
This longitudinal observational study aims to validate ultrasound-based tongue markers related to tongue characteristics, including fat accumulation, morphologic and mechanical properties of the tongue in children and adolescents…
- Conditions
- Obesity & Overweight, Pediatric Obesity, Obstructive Sleep Apnea (OSA)
- Trial name
- NCT07370350
- Testing
- Submental ultrasound
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Bruxelles-Brabant
Overweight and Obesity
Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese
A phase 2 study to evaluate the effects of apitegromab as an adjunctive therapy to GLP-1 receptor agonist therapy in subjects with overweight or obesity
- Trial name
- EMBRAZE (NCT06445075)
- Testing
- Apitegromab, Tirzepatide
- Where
- 7 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Scholar Rock, Inc.
Overweight, Obesity
A Master Protocol for Semaglutide Effects on Cardiovascular and Obesity-related Outcomes in People With Overweight or Obesity in the Real World
This study aims to evaluate the association of once-weekly semaglutide with the risk of cardiovascular (CV) and other obesity-related clinical outcomes in three study populations (Heart failure (HF), clinical Atherosclerotic…
- Conditions
- Overweight, Obesity, Heart Failure (HF), Atherosclerotic Cardiovascular Disease (ASCVD)
- Trial name
- NCT07141914
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 285,327 people
- Sponsor
- Novo Nordisk A/S
Diabetes (DM), Hypertension
Multimodal Cardiovascular Magnetic Resonance Imaging for Cardiometabolic Pre-HF and HFpEF
This is an observational study aiming to characterize the pathophysiological features and clinical significance of cardiometabolic early-stage heart failure using advanced multimodal cardiovascular magnetic resonance (CMR)…
- Conditions
- Diabetes (DM), Hypertension, Heart Failure, Obesity & Overweight
- Trial name
- NCT07336316
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Obesity & Overweight, Cardiometabolic Risk Factors
Pilot Test of Five Weight Neutral Interventions to Improve Health Among Adults of Higher Body Weight
The purpose of this research study is to pilot test five different, group based and remotely delivered programs designed to support healthy eating and regular physical activity.
- Trial name
- NEW PATH (NCT07363616)
- Testing
- Mediterranean eating style, Physical activity, Mindful Eating
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Obesity or Overweight
A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight
This study will look at how well the new medicine CagriSema helps people with excess body weight lose weight compared to another medicine, semaglutide. The participants will receive one injection once a week.
- Trial name
- NCT05813925
- Testing
- Cagrilintide, Semaglutide
- Where
- 28 sites in Japan, Taiwan
- Volunteers
- 331 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obesity
Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in Chinese Adults Who Are Above a Healthy Weight Range (OASIS 3)
This study is being conducted to see if semaglutide tablets can be used as a treatment to help people who are above a healthy weight range to lose weight.
- Trial name
- OASIS 3 (NCT05890976)
- Testing
- Semaglutide
- Where
- 16 sites in China
- Volunteers
- 200 people
- Sponsor
- Novo Nordisk A/S
High Blood Glucose, High Cholesterol
FELLAShip to Better Health
The goal of this clinical trial is to evaluate the implementation and effectiveness of the FELLAship program-a church-based cardiovascular health (CVH) intervention-in Black men aged 35-70 who are at risk for heart disease…
- Conditions
- High Blood Glucose, High Cholesterol, High Cholesterol/Hyperlipidemia, Blood Sugar; High
- Trial name
- NCT07220213
- Testing
- FELLAship
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Obesity, Overweight
Current Status of Cardiovascular Diseases in Chinese Overweight/ Obesity Population: An Epidemiological Study (COPE）
This study is testing how overweight and obesity affect cardiovascular disease (CVD) prevalence, risk factors, and mortality among Chinese adults using nationally representative CCDRFS (China Chronic Disease and Risk Factor…
- Trial name
- COPE (NCT07358052)
- Testing
- No treatment given
- Where
- 2 sites in China
- Volunteers
- 551,931 people
- Sponsor
- Novo Nordisk A/S
Insulin Resistance, Obesity & Overweight
Effects of Ketone Bodies on Insulin Sensitivity
KETO-SENSE is a clinical research study investigating how ketone bodies affect energy metabolism and insulin sensitivity in humans.
- Conditions
- Insulin Resistance, Obesity & Overweight, Energy Metabolism, Ketone Body Metabolism
- Trial name
- KETO-SENSE (NCT07359625)
- Testing
- Growth Hormone, Human, Oral ketone supplement (KetoAid®, KE4)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus