Clinical trials: Obesity and Cardiovascular Risk
Hypertension, Dyslipidemia
A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for clinicians to use to…
- Conditions
- Hypertension, Dyslipidemia, Diabetes Mellitus, Obesity
- Trial name
- P3-EX (NCT07238556)
- Testing
- Experimental - 12 Week P3-EX Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants, Active Control - 12 Week ACSM-PAVS Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants
- Where
- 3 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Connecticut
Prediabetic State, Cardiovascular Diseases
Role of Aging and Individual Variation in Exercise Training Responsiveness
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15…
- Conditions
- Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
- Trial name
- STRRIDE IV (NCT06471569)
- Testing
- Low/Mod, High/Mod, High/Vig
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Obesity Morbid, Obesity-Associated Insulin Resistance
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients
Epidemiological studies show a very rapid increase in the epidemic of obesity in the Caribbean population. 6 out of 10 adults are overweight and 1 out of 4 is obese. Most are women.
- Trial name
- BARIAMITRI (NCT04814147)
- Testing
- Sleeve gastrectomy
- Where
- Martinique
- Volunteers
- 20 people
- Sponsor
- University Hospital Center of Martinique
Obesity, Cardiovascular Risk Factor
Visualizing Vascular Mechanisms of Salt Sensitivity
This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.
- Conditions
- Obesity, Cardiovascular Risk Factor, Salt; Excess
- Trial name
- NCT03696433
- Testing
- Low-salt diet, High-salt diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Metabolic Disease, Cardiovascular Diseases
HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking
This clinical trial investigates whether incorporating stair walking into daily routines improves physical health in adults at risk of lifestyle-related conditions such as hypertension, type 2 diabetes, and cardiovascular…
- Conditions
- Metabolic Disease, Cardiovascular Diseases, Hypertension, Obesity and Overweight
- Trial name
- HYPERWALK (NCT06952348)
- Testing
- Stair and brisk walking combined, Brisk walking, Standard care
- Where
- 4 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Obesity and Obesity-related Medical Conditions, Cardiovascular Risk
Cardiometabolic Risk of Obese Subjects: Cross-sectional Study
experimental study with analysis on tissues. This study aims to study cardiometabolic risk from a genetic, clinical, instrumental and laboratory point of view in a population of subjects with obesity.
- Conditions
- Obesity and Obesity-related Medical Conditions, Cardiovascular Risk, Genetics
- Trial name
- MiRNome (NCT06714058)
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiovascular Diseases
Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents
The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.
- Trial name
- NCT00889876
- Testing
- Metformin group, Exercise
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Maria Sandberg Westerstahl
Overweight, Obesity
Glycemic Load, Weight Loss and Cardiovascular Disease Risk
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors.
- Trial name
- NCT00254215
- Testing
- high protein & low glycemic index diets
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Overweight and Obesity
Dietary Treatment Study of Fat Synthesis and Risk of Cardiovascular Disease
The purpose of this study is to find out how the amount of fat or sugar in a person's diet, or the number of meals eaten each day, affect the amount of fat that people's bodies make, the types of fats in the bloodstream, and how…
- Trial name
- NCT02075710
- Testing
- High sugar/meal feed, High sugar/nibble, High fat/meal feed
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Cardiovascular Diseases
HIIT Effects on Cardiometabolic Health
The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity.
- Conditions
- Obesity, Cardiovascular Diseases, Metabolic Disease, High-intensity Interval Training
- Trial name
- NCT05838950
- Testing
- high-intensity interval training intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Syracuse University
Cardiovascular Diseases, Diabetes
South Asian HeArt Risk Assessment Project - Pilot
People who originate from the Indian subcontinent known as South Asians are the fastest growing group of non-white Canadians. They suffer an excess prevalence of abdominal obesity, type 2 diabetes and heart disease.
- Conditions
- Cardiovascular Diseases, Diabetes, Abdominal Obesity
- Trial name
- SAHARA-Pilot (NCT01577719)
- Testing
- Multimedia Lifestyle Improvement, Usual Care
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Diseases, Coronary Disease
20 Year Changes in Fitness & Cardiovascular Disease Risk - Ancillary to CARDIA
To understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- NCT00106457
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome
A Mediterranean Diet-Based Culinary Intervention in Adults With Metabolic Syndrome
Metabolic syndrome is a major public health concern associated with an increased risk of cardiovascular disease, type 2 diabetes, and premature mortality.
- Trial name
- CUINAMET (NCT07702695)
- Testing
- Mediterranean diet-based culinary intervention, Standard nutritional counseling
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cardiovascular Disease (CVD), Hypertension
Veteran Peer Coaches Optimizing and Advancing Cardiac Health
The purpose of this study is to test if having a Veteran peer health coach will improve blood pressure control among Veterans with high blood pressure and at least one other Cardiovascular disease (CVD) risk factor.
- Conditions
- Cardiovascular Disease (CVD), Hypertension, Hyperlipemia, Obesity
- Trial name
- Vet-COACH (NCT02697422)
- Testing
- Community-based peer health coach intervention
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Physical Activity
Smart Walk: A Physical Activity Program for African American Women
The purpose of this project is to test an 8-month, culturally relevant, Smartphone-delivered PA program to improve and maintain high physical levels and reduce cardiometabolic disease risk among obese AA women.
- Trial name
- NCT02823379
- Testing
- Physical Activity, Wellness
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Atrial Fibrillation Paroxysmal
Atrial Fibrillation Lifestyle Project
The objectives of the investigators are to demonstrate a reduction in frequency and symptoms of AF and improvements in cardiovascular risk factors following a lifestyle intervention in patients with paroxysmal AF.
- Trial name
- ALP (NCT03724383)
- Testing
- Risk Factor Management Consult, Diet Classes, Stress Management Classes
- Where
- 7 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Teddi Orenstein Lyall
Sedentary Lifestyle, Overweight and Obesity
The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors
The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.
- Conditions
- Sedentary Lifestyle, Overweight and Obesity, Metabolic Disease
- Trial name
- BPS2 (NCT02951624)
- Testing
- Control, Breaker, Prolonger
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Abdominal Obesity, Metabolic Syndrome
The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
The prevalence of overweight and lifestyle related diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is increasing world wide.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- MERITS (NCT02931630)
- Testing
- Whey protein powder, Maltodextrin powder, High fiber bread
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Type 2 Diabetes Mellitus, Obesity
Date Seed Extract Effectiveness in Controlling Diabetes and Cardiovascular Risk in T2DM
Globally, chronic noncommunicable diseases rank as the leading cause of morbidity and mortality. Diabetes is reaching high epidemic proportions across the globe.
- Trial name
- NCT06590519
- Testing
- Date Seed Extract
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- Universiti Putra Malaysia
Obesity
Effects of a Ketogenic Diet on Body Weight and Cardiovascular Risk Factors
This pilot study is a randomized, controlled clinical trial to compare anthropometric and metabolic changes associated with six months of weight management by means of a very low carbohydrate diet or a calorically-restricted low…
- Trial name
- NCT00498394
- Testing
- Clinical diet trial
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati