Clinical trials: Obesity in Pregnancy
Infertility, Obesity
Physical Activity and ARTs
Obese women experience increased infertility rate and longer time to conception showing lower pregnancy and live-birth rates both in natural and assisted conceptions.
- Conditions
- Infertility, Obesity, Stable BMI
- Trial name
- SETART (NCT01892111)
- Testing
- Structured exercise program.
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Modena and Reggio Emilia
Overweight, Obesity
Research Study to Investigate the Effect of NNC0174-0833 on a Birth Control Pill in Women Who Are Not Able to Become Pregnant
The study looks at how the study medicine affects the level in the blood of a birth control pill. The study also looks at how the study medicine affects the duration of emptying of the stomach.
- Trial name
- NCT04074174
- Testing
- NNC0174-0833, Oral contraceptive (OC) tablets, Acetaminophen
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Novo Nordisk A/S
Obesity, Weight Gain, Maternal
Using Mental Imagination to Prevent Excessive Gestational Weight Gain in Overweight and Obese Pregnant Women
Moms Are Worth It is a lifestyle behavior intervention study aims to prevent excessive gestational weight gain in overweight or obese pregnant women through promotion of the stress management, healthy eating, and physical…
- Trial name
- MAWI (NCT04623008)
- Testing
- Goal-Oriented Episodic Future Thinking
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Obesity
The Effect of Obesity on Pregnancy and Fetal Outcome in Glucose Tolerant Mothers
The participants are divided into subjects or controls based on the BMI taken during the first trimester of pregnancy upon recruitment.
- Trial name
- NCT04116268
- Where
- Malaysia
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Hypothalamic Obesity
Open-Label Study of Setmelanotide in Hypothalamic Obesity
Open-label, single-arm study designed to evaluate the body weight response to setmelanotide administered subcutaneously (SC) daily in participants with hypothalamic obesity (HO).
- Trial name
- NCT04725240
- Testing
- Setmelanotide
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Poly Cystic Ovary Syndrome, Overweight , Obesity
Physical Activity and Cardiometabolic Health in Women With or Without Polycystic Ovary Syndrome (SCOPAP)
The primary objective of this study is to investigate the effects of a multidisciplinary intervention, including a targeted adapted physical activity program, on lipid oxidation during a walking exercise in women with overweight…
- Trial name
- SCOPAP (NCT07659392)
- Testing
- Physical activity
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Metabolic Syndrome (MetS), Obesity & Overweight
Validating Integrative Multi-omics Approaches in Metabolic Syndrome-related Diseases
This study aims to validate integrative multi-omics approaches for understanding complications related to metabolic syndrome. By combining genetic, transcriptomic, metabolomic, and microbiome data from participants with and…
- Conditions
- Metabolic Syndrome (MetS), Obesity & Overweight, Cardiovascular Diseases (CVD), Chronic Kidney Disease
- Trial name
- NCT07248371
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 6,266 people
- Sponsor
- Chang Gung Memorial Hospital
Pre-eclampsia, Obesity
ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
Obesity is a growing problem in East London and every other woman who enters pregnancy is obese or overweight. In addition to obesity, other metabolic risk factors such as raised lipids, high blood pressure and diabetes increase…
- Conditions
- Pre-eclampsia, Obesity, Raised Lipids, High Blood Pressure
- Trial name
- ESTEEM (NCT02218931)
- Testing
- Targeted ESTEEM diet, Non-randomised cohort
- Where
- United Kingdom
- Volunteers
- 3,442 people
- Sponsor
- Queen Mary University of London
Gestational Diabetes
Human Milk: Understanding the Mechanisms Linked to the Prevention of Obesity and Diabetes in Children Exposed in Utero to Gestational Diabetes
Breastfeeding has been associated with decreased obesity. However, this relationship is not as clear in children who have been exposed to GDM and the mechanisms involved are little known.
- Trial name
- LAIT-M (NCT04263675)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Autosomal Dominant Polycystic Kidney, Obesity
Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body's response to glucose and insulin, can…
- Trial name
- NCT06582875
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Colorado, Denver
Prader-Willi Syndrome, Hypothalamic Obesity
Tirzepatide in PWS, HO and GNSO
This research study is comparing the effectiveness of a weight loss medication called Tirzepatide in young adults with Prader-Willi Syndrome and/or hypothalamic obesity, as compared to young adults with obesity that is unrelated…
- Conditions
- Prader-Willi Syndrome, Hypothalamic Obesity, Obesity/Therapy
- Trial name
- NCT06901245
- Testing
- Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Grace Kim
Polycystic Ovary Syndrome
GLP-1 RAs in Patients With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with a prevalence of 5% to 15% in premenopausal women. Patients with PCOS presents as abnormal menstruation, ovulation disorders and/or hyperandrogenemia, and often…
- Trial name
- NCT04876027
- Testing
- GLP-1 RAs, calorie restricted diet
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai 10th People's Hospital
HIV Nephropathy, Kidney Injury
Genetic Determinants of Kidney Disease in People of African Ancestry With HIV
Black ethnicity is a major risk factor for chronic kidney disease [CKD] in people with HIV infection, suggesting that genetic factors are an important determinant of kidney disease progression in this population.
- Conditions
- HIV Nephropathy, Kidney Injury, Kidney Diseases, Diabetes Mellitus
- Trial name
- GEN-AFRICA (NCT05685810)
- Where
- United Kingdom
- Volunteers
- 3,029 people
- Sponsor
- King's College Hospital NHS Trust
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1), Polycystic Ovary Syndrome
Hepassocin Levels in Patients With Polycystic Ovary Syndrome
The investigators aimed to investigate hepassocin levels in patients with polycystic ovary syndrome (PCOS). There are 3 groups aged between 18 and 35 years as non-obese healthy women, non-obese women with PCOS, and obese women…
- Conditions
- Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1), Polycystic Ovary Syndrome, Obesity, Insulin Resistance
- Trial name
- NCT04369248
- Testing
- hepassocin
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fatma ketenci gencer
Body Weight, Polycystic Ovary Syndrome
The Effect of Obesity on Endometrium in PCOS
The effect of Polycystic Ovary Syndrome (PCOS) with or without obesity has received a few attentions. There is a lack of evidence to whether the BMI affects the endometrial blood flow, which is necessary for implantation.
- Trial name
- OB-PCO (NCT02694419)
- Testing
- Doppler evaluation
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Gestational Diabetes, Diabetes Type 2
Genetics of Beta Cell Failure in Mexican Americans
This is a family based genotype-phenotype study designed to assess genetic and environmental influences on obesity, insulin resistance and beta cell function in the context of gestational diabetes.
- Conditions
- Gestational Diabetes, Diabetes Type 2, Insulin Resistance, Beta Cell Function
- Trial name
- NCT03301519
- Volunteers
- 1,250 people
- Sponsor
- University of Southern California
Pregnancy Related
Exploration of Women's Experiences and Technology Usage Before, During, and After Pregnancy in Singapore
This study seek to understand the motivations and contextual influences that can induce and sustain behaviour change to inform future interventions for women before, during and after pregnancy, through a qualitative…
- Trial name
- NCT05099900
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Pregnancy, Obesity
Fitness Improvement in Obese, Pregnant Women: an Intervention Trial
In pregnancy, the adoption or pursuit of a sedentary lifestyle contributes to the development of co-morbid conditions such as hypertension, maternal and childhood obesity, gestational diabetes, pre-eclampsia, cesarean section and…
- Conditions
- Pregnancy, Obesity, Physical Activity
- Trial name
- InterGOFIT (NCT01610323)
- Testing
- Exercise intervention, Standard Care
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Gestational Diabetes
Optimizing Outcomes in Women With Gestational Diabetes Mellitus and Their Infants
The purpose of this study is to determine whether a 14 week intervention is successful in improving outcomes for women with gestational diabetes mellitus and their infants.
- Trial name
- NCT01809431
- Testing
- Intervention
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill