Clinical trials: Observation of Neuromuscular Block
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Neostigmine
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- DECURATOF 2 (NCT05224648)
- Testing
- TOF scan train of four ratio monitoring, ITF device tetanus stimulation monitoring
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Urinary Retention Postoperative, Laparoscopic Cholecystectomy
Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine Versus Sugammadex
This study is intended to be a single-site, prospective, randomized, controlled study that intends to enroll a total of 230 patients undergoing laparoscopic cholecystectomy at Parkland Hospital.
- Conditions
- Urinary Retention Postoperative, Laparoscopic Cholecystectomy, Neuromuscular Blockade, Sugammadex
- Trial name
- NCT05794503
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Neuromuscular Block, Surgery
MRI Measurement of the Effects of Deep Neuromuscular Blockade on the Abdominal Working Space During Laparoscopy
During laparoscopy, a surgical working space is obtained by creation of a pneumoperitoneum. Optimal surgical conditions are essential to ensure the patient's safety.
- Trial name
- RELAX-2 (NCT03287388)
- Testing
- No Rocuronium, Rocuronium (moderate NMB), Rocuronium (deep NMB)
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Residual Neuromuscular Block (TOF-ratio of 0.2)
Sugammadex and Neostigmine at Residual Neuromuscular Blockade
This study is designed to compare recovery times after reversal of a residual neuromuscular block (TOF-ratio 0.2) with different doses of either neostigmine or sugammadex.
- Trial name
- SUNDRO20 (NCT01006720)
- Testing
- Sugammadex, Neostigmine, Saline
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Technical University of Munich
Chronic Pain, Complex Regional Pain Syndromes
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
The patient, who is experiencing chronic pain in the lower extremities persisting for more than three months, is scheduled to undergo lumbar sympathetic ganglion block.
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Peripheral Neuropathy, Post Herpetic Neuralgia
- Trial name
- NCT06241820
- Testing
- Lumbar Sympathetic Ganglion Block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeongsoo Kim
Neuropathic Pain, Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
Hematological Indices and Sympathetic Block Response in Neuropathic Pain
This prospective observational study aims to evaluate the relationship between hematological inflammatory indices and clinical treatment response in patients with neuropathic pain undergoing sympathetic nerve block procedures as…
- Trial name
- HINSPAIN (NCT07596823)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthesia, Neuromuscular Blockade
International Focus Group Discussion on Neuromuscular Monitoring.
Focus-Group based discussion designed to gain more in-depth information on factors that could lead to an increase in the adoption of neuromuscular monitoring taking into account different country-specific contexts.
- Conditions
- Anesthesia, Neuromuscular Blockade, Neuromuscular Block, Residual, Perioperative/Postoperative Complications
- Trial name
- NCT06945341
- Testing
- Focus-Group discussion
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Obesity
Comparison of Acceleromyography and Electromyography in Obese Patients Undergoing General Anesthesia
The goal of this prospective observational study is to compare two different methods of monitoring muscle relaxation during anesthesia - acceleromyography (AMG) and electromyography (EMG) - in people with obesity who are having…
- Trial name
- OBAEG (NCT07283354)
- Testing
- Neuromuscular monitoring with electromyography (EMG), Neuromuscular monitoring with acceleromyography (AMG)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Padova
Postoperative Residual Curarization, Neuromuscular Block Prolonged
Postoperative Residual Neuromuscular Block and Passive Smoke Exposure in Pediatric Dental Patients
Postoperative residual neuromuscular block (PRNB) may persist despite apparent clinical recovery from neuromuscular blockade and may increase the risk of postoperative respiratory complications.
- Trial name
- NCT07831434
- Testing
- Passive Smoke Exposure
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University - Cerrahpasa
Underdosing of Other General Anesthetics
Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex
The primary efficacy endpoint is the time from the start of administration of sugammadex to recovery of the TOF ratio to 0.9 in deep neuromuscular block (1-2 twitches post-tetanic count) induced by rocuronium during mild…
- Trial name
- NCT01965067
- Testing
- sugammadex
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- MSD Korea Ltd.
Incomplete Reversal of Neuromuscular Block
The Effect of Dexamethasone on Sugammadex Reversal
The purpose of this study is to determine whether dexamethasone extends the duration of recovery from anesthesia.
- Trial name
- NCT02137395
- Testing
- Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Neuromuscular Blockade, Anesthesia
Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular
The aim of this study is to evaluate whether the use of Sugammadex for reversing the neuromuscular blocking effects of rocuronium during neurointerventional procedures can speed recovery of neuromuscular function.
- Trial name
- NCT03322657
- Testing
- Neostigmine, Glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The Cleveland Clinic
Neuromuscular Blockade
Qualitative Analysis of Barriers to Consistent Use of Neuromuscular Monitoring in General Anaesthesia
Monitoring the degree of neuromuscular blockade in general anaesthesia reduces complications and patient discomfort. However, monitoring is not applied consistently by Danish anaesthesia personnel.
- Trial name
- NCT02239965
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Herlev Hospital
Lumbar Spine Disease
Deep Neuromuscular Block on Postoperative Delirium in Lumbar Surgery
The effect of deep neuromuscular blockade (NMB) during spine surgery reduced postoperative pain and bleeding in recent studies. Therefore by reducing these two factors, which were the contributing factors for postoperative…
- Trial name
- NCT05453929
- Testing
- Rocuronium for deep NMB, Rocuronium for moderate NMB
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Korea University Guro Hospital
Neuromuscular Blockade
Incidence of Incomplete Postoperative Neuromuscular Recovery From Anesthesia (P07535)(Completed)
This is a multicenter, observational study in adult participants undergoing different types of elective surgical procedures requiring general anesthesia.
- Trial name
- INSPIRE (NCT01181349)
- Testing
- Neuromuscular Blocking Agent (NMBA)
- Volunteers
- 350 people
- Sponsor
- Merck Sharp & Dohme LLC
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Cervical Intervertebral Disc Disease, Cervical Spinal Stenosis
Prospective Observation of the Fluoroscopy-guided Cervical Epidural Approach Using the Contralateral Oblique View
The aim of the present study is to investigate the safety and clinical utility of contralateral oblique view for fluoroscopic guided cervical epidural access.
- Conditions
- Cervical Intervertebral Disc Disease, Cervical Spinal Stenosis, Cervical Radicular Pain, Herpes Zoster
- Trial name
- NCT04774458
- Testing
- Fluoroscopic-guided cervical epidural access
- Where
- South Korea
- Volunteers
- 439 people
- Sponsor
- Asan Medical Center
Feasibility of Measurement of a Neuromuscular Block at the m. Trapezius
Accelerometry at the Neck: Comparison With m. Adductor Pollicis Stimulation
Accelerometric Assessment of neuromuscular block during anaesthesia is routinely performed at the M. adductor pollicis. However, many operations require positioning of the patients with arms attached to the body.
- Trial name
- NCT01849198
- Testing
- accelerometry m. trapezius and m. adductor pollicis
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Kreiskrankenhaus Dormagen
Incomplete Reversal of Neuromuscular Block, Postoperative Respiratory Complications
Multi-center Study of Residual Neuromuscular Block Incidence in the Post-anesthesia Care Unit
Residual neuromuscular block (RNMB) is frequent in the immediate postoperative period and is a source of complications, mainly respiratory. The incidence is variable due to multiple factors. In Spain the incidence is unknown.
- Trial name
- ReCuSS (NCT02226809)
- Testing
- Accelerometry
- Where
- 25 sites in Spain
- Volunteers
- 763 people
- Sponsor
- University of Valencia
Neuromuscular Block, Residual
Monitoring of Postoperative Residual Neuromuscular Blockade in Laparoscopic Surgery
Compare the reversal effect of neostigmine and sugammadex using quantitative neuromuscular monitoring
- Trial name
- NCT03292965
- Testing
- Neostigmine, Sugammadex
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital