Clinical trials: Obstetrical Condition
Behavior Problem
Changing the Culture of Disrespect and Abuse in Maternity Care in Kumasi, Ghana
Using a public health facility Komfo Anokye Teaching Hospital in Ghana the overall goal of the research is to examine: 1) the feasibility of implementing respectful care modules (RMC-M) in Kumasi, Ghana; 2) whether exposure to…
- Trial name
- NCT04288947
- Testing
- Disrespect and Abuse in Maternity Care
- Where
- Ghana
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
Episiotomy; Dehiscence
The Effect of Virtual Reality Glasses Applied During Vaginal Incision Suturing on Pain and Satisfaction
The research was conducted as a randomized controlled clinical study to determine the effect of virtual reality glasses on pain and patient satisfaction during the episiotomy repair procedure.
- Trial name
- NCT05578989
- Testing
- Virtual reality glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Neonate, Maternal Transmission
Phase 3 Maternal Safety & Immunogenicity Trial of MVA-BN® in DRC
This Phase 3 open-label study aims to assess the safety and immune response of the MVA-BN mpox vaccine when administered subcutaneously to pregnant and postpartum women in the Democratic Republic of the Congo (DRC), a population…
- Conditions
- Neonate, Maternal Transmission, Mpox, Vaccination
- Trial name
- PregInPoxVac (NCT06844500)
- Testing
- MVA-BN standard regimen, MVA-BN standard regimen (Administered as PEP)
- Where
- Democratic Republic of the Congo
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Jean-Pierre Van geertruyden
Labor Pain, Nociceptive Pain
Nociception Level Index (NOL Index) for Obstetrical Pain Assessment Under Epidural Analgesia.
Pain has been defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".
- Conditions
- Labor Pain, Nociceptive Pain, Epidural Analgesia, NOL Index
- Trial name
- NCT05898737
- Testing
- NOL-Index
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Postpartum Hemorrhage, Uterine Atony
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage
The objective of the study is to demonstrate whether cooling the uterine smooth muscle during cesarean section (following delivery of the fetus) will promote better uterine contraction and involution resulting in lower blood…
- Trial name
- NCT02229513
- Testing
- Uterine Cooling
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Labor Dystocia, Labor Complication
The Norwegian World Health Organisation Labour Care Guide Trial (NORWEL)
Appropriate and timely care during birth is critical to the survival and health of women and their babies. In 2020, the World Health Organization (WHO) presented the Labour Care Guide (LCG) as the new recommended tool for…
- Conditions
- Labor Dystocia, Labor Complication, Labor Onset and Length Abnormalities, Labor (Obstetrics)--Complications
- Trial name
- NORWEL (NCT05791630)
- Testing
- the labour care guide (LCG)
- Where
- 10 sites in Norway
- Volunteers
- 23,650 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Inflammatory Response, Abortion, Habitual
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells
The investigators have found that NLRP7 was upregulated and nuclear translocated in an in vitro model of decidualization. Knock-down or overexpression of NLRP7 reduced or enhanced the expression of decidual marker IGFBP-1.
- Trial name
- NCT04148638
- Where
- Taiwan
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Hemorrhage, Postpartum, Placenta Previa
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans.
- Trial name
- TRAPP (NCT05811676)
- Testing
- Tranexamic acid, 0.9% sodium chloride
- Where
- 27 sites in China
- Volunteers
- 1,732 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Analgesia Obstetrical, Analgesia
Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia
Cesarean section is one of the most commonly performed surgical procedures worldwide, making effective management of acute postoperative pain a key issue in obstetric anesthesiology.
- Conditions
- Analgesia Obstetrical, Analgesia, Post Operative Pain, Patient Satisfaction
- Trial name
- NCT07386353
- Testing
- Intrathecal Morphine, Epidural Morphine
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Central do Funchal
Language Disorders
China Obstetrics and Gynecology Journal Club
The purpose of this study is to determine if an intensive journal club based on articles and materials provided on the journal Obstetrics and Gynecology Website improves written and spoken comprehension of medical English in a…
- Trial name
- COG-JOCS (NCT01844609)
- Testing
- Self Study Journal Club, Intensive Journal Club
- Where
- 2 sites in United States, China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Reproductive Tract Infections
Evaluation of Immediate v. Delayed CT/NG Test for Treatment in the ED
The purpose of this study is to determine if immediate availability of GeneXpert® CT/NG test results reduces the overtreatment rate for ED patients with suspected gonorrhea or chlamydia and to assess changes in clinician…
- Trial name
- NCT01989130
- Testing
- Roche AMPLICOR CT/NG, Cepheid Xpert CT/NG Test
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Washington University
Obstetric Pain, Pain
Virtual Reality in Obstetric Patients
The purpose of this study is to determine if non-invasive distracting devices (Virtual Reality headset) are more effective than the standard of care (i.e., no technology based distraction) for preventing anxiety and pain scores…
- Trial name
- NCT03495531
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Preeclampsia, Intrauterine Growth Restriction
Fetal, Obstetrics and Reproduction Genomics
The purpose of this study is to determine the impact of a clinical screening strategy and genomic analysis of the factors involved in Placental Dysfunction (Preeclampsia and IUGR) in women of advanced maternal age undergoing…
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Placental Disease
- Trial name
- FORgenomics (NCT05720169)
- Testing
- Doppler ultrasound, Blood sample
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundación Ginemed
Analgesia, Obstetrical
Hyoscine ButylBromide for Intrapartum Analgesia
The aim of this study is to assess whether hyoscine butylbromide is as effective as pethidine for analgesia during the first stage of labor.
- Trial name
- NCT02557087
- Testing
- Hyoscine, Pethidine
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Polycystic Ovary Syndrome
Effects of Oral Inositol Supplementation on Obstetrics Outcomes in PCOS Women
Polycystic ovarian syndrome (PCOS) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (IR), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility.
- Trial name
- IPOSI-1 (NCT03585738)
- Testing
- Inositol + Folic acid, Folic acid
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Gynecologic Disease
Traditional Versus Virtual Reality for Surgical Skills for ObGyn Residents
This study will verify if a comprehensive laparoscopic curriculum using virtual reality demonstrates skills transfer to the operating room, compared to the traditional teaching method.
- Trial name
- SIMUTEC (NCT03395821)
- Testing
- Conventional training, Virtual Reality+conventional training
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Post-Dural Puncture Headache
Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study
The purpose of this study is to determine the effect of 19g versus =>18g traditional Tuohy-type epidural needles on the incidence and severity of postdural puncture headache (PDPH).
- Trial name
- NCT00370604
- Testing
- 19g Tuohy-type epidural needle, 23g catheter, => 18g Tuohy-type needle
- Where
- 4 sites in Canada
- Volunteers
- 1,081 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Work-related Injury, Work Related Upper Limb Disorder
Surgical Ergonomics Education During Minimally Invasive Gynecologic Skills Training
The goal of this pilot study is to learn if a class and hands-on-practice of ergonomic body positions - or specific ways to move the body while working to prevent injury - is valuable to training obstetrics and gynecology…
- Conditions
- Work-related Injury, Work Related Upper Limb Disorder, Surgery, Educational Problems
- Trial name
- SEE MIGS (NCT06386601)
- Testing
- Ergonomics Knowledge, Ergonomics Feedback/Guided Practice
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Missed Abortion, Pregnancy
Mifepristone and Misoprostol Versus Misoprostol Alone for Missed Abortion: A Randomized-controlled Trial
The purpose of the proposed study is to compare - in a randomized, placebo-controlled, double-blinded trial - a combination of mifepristone and misoprostol to misoprostol used alone for missed abortion.
- Trial name
- NCT02342002
- Testing
- Mifepristone, Misoprostol
- Where
- 4 sites in Argentina, Gabon and 2 more
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects