Clinical trials: Obstructive Sleep Apnoea Hypopnoea Syndrome
Sleep Apnea, Obstructive Sleep Apnea
Zonisamide for the Treatment of Obstructive Sleep Apnea in Overweight/Obese Patients
This RCT explores the efficacy of Zonisamide (Zonegran®)on overweight/obese in patients with moderate to severe obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Obesity
- Trial name
- NCT01765608
- Testing
- Zonisamide, nCPAP
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Göteborg University
Sleep Apnea, Obstructive
AcuPebble to Remotely Monitor Patients With OSA on CPAP Therapy
Obstructive sleep apnoea (OSA) is a breathing problem that happens when you sleep. It is treated by a machine called continuous positive airway pressure (CPAP) therapy.
- Trial name
- NCT06097949
- Testing
- AcuPebble SA100
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Obstructive Sleep Apnea (OSA), Post-Traumatic Stress Disorder (PTSD)
Comparison Study Using APAP With and Without SensAwake in Patients With OSA and PTSD
The purpose of this research is to examine the application of AutoCPAP with and without SensAwake in subjects with OSA and Post-Traumatic Stress Disorder (PTSD), and evaluate whether patients achieve better sleep quality and…
- Trial name
- NCT02549508
- Testing
- AutoCPAP with SensAwake On, AutoCPAP with SensAwake Off
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Overhydration
Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients
The purpose of this study is to investigate the effect of decreasing fluid overload by hemodialysis on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease on intermittent hemodialysis.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease
- Trial name
- SASinHD (NCT01860209)
- Testing
- Hemodialysis
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity, Overweight
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure.
- Conditions
- Obesity, Overweight, Obstructive Sleep Apnoea
- Trial name
- AMAZE 4 (NCT07571109)
- Testing
- NNC0487-0111
- Where
- 92 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Obstructive Sleep Apnea
Positioning of Surgical Patients With Sleep Apnea
The study aims to evaluate the effect of non-supine positioning in the treatment of surgical patients with obstructive sleep apnea.
- Trial name
- NCT02123238
- Testing
- bed positioning
- Where
- United States
- Sponsor
- Englewood Hospital and Medical Center
Obstructive Sleep Apnea
Effect of Tibet Rhodiola Capsule on Hypoxia and Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea
The purpose of this study is to evaluate the effect of Tibet Rhodiola Capsule on hypoxia and the cardiovascular risk factors in patients with mild to moderate OSA.
- Trial name
- NCT03163615
- Testing
- Tibet Rhodiola Capsule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shao-Ping Nie
OSA - Obstructive Sleep Apnea
Comparative Study of CPAP Predictive Equations and In-laboratory Manual Titration in Thai Patients With Obstructive Sleep Apnea
The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA).
- Trial name
- NCT07376343
- Testing
- Sleep test, Predictive equations of continuous positive airway pressure (CPAP)
- Where
- 2 sites in Thailand
- Volunteers
- 150 people
- Sponsor
- Thammasat University
Heart Failure, Obstructive Sleep Apnea
The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure
This study will evaluate whether treating sleep apnea while in the hospital would help heart failure, and assist recovery from the worsening of the heart function more than the current clinical standard of waiting for treatment…
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Heart Failure, Congestive
- Trial name
- NCT00679549
- Testing
- CPAP Therapy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Ohio State University
Obstructive Sleep Apnea
Predicting Cardiometabolic Risk in Mild-to-Moderate Obstructive Sleep Apnea: Inflammation vs. Apnea/Hypopnea Index
The purpose of the study is to compare the relative contribution of systemic inflammation vs. Obstructive Sleep Apnea (OSA) severity (as measured by Apnea Hypopnea Index) in predicting cardiovascular and metabolic aberrations…
- Trial name
- NCT03062748
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Milton S. Hershey Medical Center
Head and Neck Cancer, Obstructive Sleep Apnea
Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
Recently published data suggest that stimulation of the infrahyoid strap muscles increases pharyngeal patency in patients with obstructive sleep apnea, but the innervation of these muscles by the ansa cervicalis is variable.
- Trial name
- ACS (NCT05650710)
- Testing
- Nerve stimulation using nerve stimulation device and sterile wire electrode.
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea
Determination of Upper Airway Collapsibility During Routine CPAP Titration
The investigators hypothesis is that upper airway collapsibility (Pcrit) in patients with obstructive sleep apnea (OSA) can be measured using equipment found in the clinical sleep laboratory and these Pcrit measurements obtained…
- Trial name
- NCT02566278
- Testing
- Upper airway collapsibility (Pcrit)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Safety Monitoring for a Novel 3D Printed Mandibular Advancement Device
The purpose of this study is to evaluate the safety profile of the novel oral appliance (OA )device and to assess patient comfort of the novel OA device.
- Trial name
- NCT05018234
- Testing
- Noval Oral Appliance
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obstructive Sleep Apnea
Impact of Polyphenols on Endothelial Function in Obstructive Sleep Apnea
Severe obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Endothelial dysfunction, an early marker of vascular disease has been demonstrated in OSA.
- Trial name
- PolySAS (NCT01977924)
- Testing
- one month polyphenols supplementation (600mg)
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Sleep Apnea
Surgical Treatment of Mild Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is one of the most common sleep disorder. There are numerous conditions that are related to OSA, such as diabetes, cardiovascular diseases, and metabolic syndrome.
- Trial name
- NCT00747890
- Testing
- Modified tonsillectomy, Lifestyle counselling by physician
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Kuopio University Hospital
Sleep Apnea, Obstructive, Patient Compliance
Continuous Positive Airway Pressure (CPAP) Compliance in Obstructive Sleep Apnea
This study aims to determine the average compliance of a patient under CPAP therapy for obstructive sleep apnea as well as the various factors that influence it.
- Trial name
- CPAPcompl (NCT02301923)
- Where
- Lebanon
- Volunteers
- 450 people
- Sponsor
- Saint-Joseph University
Obstructive Sleep Apnea (OSA)
Patient-Perceived Symptoms at the Center of Obstructive Sleep Apnea (OSA) Management: Validation of the French Version of the Patient-Reported Apnea Questionnaire (PRAQ)
Obstructive sleep apnea (OSA) is a common and disabling sleep disorder in which the assessment and monitoring of symptoms are central to patient management.
- Trial name
- PRAQ (NCT07836062)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Obstructive Sleep Apnea
A Study for Obstructive Sleep Apnea Using a New At-Home Sleep Test
The purpose of the study is to test the workflow of an auto-titrating mandibular positioner in its intended setting. Participants with obstructive sleep apnea will use the device to determine their eligibility for oral appliance…
- Trial name
- NCT03049982
- Testing
- Auto-titrating mandibular positioner test
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Zephyr Sleep Technologies
Obstructive Sleep Apnea Syndrome
Study of Acceptability and Tolerance of an Orofacial Myofunctional Rehabilitation Pacifier in Infants
The development of the medical device tested was inspired by palatal plates used to treat myofunctional disorders in young patients with Down syndrome.
- Trial name
- YooTET (NCT06489223)
- Testing
- Orofacial Myofunctional Rehabilitation Pacifier
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Obstructive Sleep Apnea
BASET Scoring: A Novel Simple Biometric Score and Potential Tool for Diagnosis and Grading of Obstructive Sleep Apnea Syndrome (OSAS) Patients
this study aims to assess the validity of BASET scoring as a new potential tool for diagnosis and grading the severity of OSAS patients and as screening of the risk factors of OSAS.
- Trial name
- BASET (NCT05511974)
- Testing
- BASET score
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Mansoura University
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