Clinical trials: Occlusion Carotid
Carotid Artery Stenosis
Evaluation of the 3-in-1 Neuroguard IEP System for Carotid Artery Stenosis
The Neuroguard IEP System is a 3-in-1 carotid stent delivery system consisting of an angioplasty balloon, an integrated embolic protection device and a nitinol self-expanding stent loaded over the balloon and constrained by an…
- Trial name
- PERFORMANCE (NCT04142541)
- Testing
- Neuroguard® IEP 3-in-1 Carotid Stent and Post-Dilation Balloon System with Integrated Embolic Protection (Neuroguard IEP System)
- Where
- 6 sites in Germany, Italy
- Volunteers
- 67 people
- Sponsor
- Contego Medical, Inc.
Rheumatoid Arthritis
The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid Arthritis
The purpose of this study is to access the effect (week 12/week 24) of puerarin injection on carotid intima-media thickness (CIMT) in rheumatoid arthritis (RA) patients despite routine anti-rheumatic treatment.
- Trial name
- NCT02254655
- Testing
- Puerarin injection 400 mg, Control
- Volunteers
- 119 people
- Sponsor
- Chengdu PLA General Hospital
Carotid Artery Stenosis, Carotid Atherosclerosis
New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis
Background and purpose. Even if periprocedural cerebral microembolism associated with carotid endarterectomy or stenting usually does not manifest as clinically overt stroke, neuropsychological disturbances resulting from these…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Stroke, Ischemic
- Trial name
- CARECarotid (NCT03764306)
- Testing
- Carotid Artery Stenting, Endarterectomy carotid artery
- Volunteers
- 31 people
- Sponsor
- Jagiellonian University
Atherosclerosis, Carotid Stenosis
Investigation of Plaque Instability Using Bevacizumab-800CW and MSOT
Determining whether we could visualize uptake of the fluorescent tracer Bevacizumab-800CW, targeting VEGF-A in atherosclerotic plaques by using the new imaging technique Multispectral Optoacoustic Tomography both in- and ex vivo.
- Conditions
- Atherosclerosis, Carotid Stenosis, Fluorescence
- Trial name
- Carotid (NCT03757507)
- Testing
- MultiSpectral Optoacoustic Tomography
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- G.M. van Dam
Carotid Artery Plaque
The Evaluation of Tomographic 3D Ultrasound for the Assessment of Vascular Pathology
This study concentrates on providing more ultrasound image details when scanning vascular system including arterial and venous systems. A new sensor which provides 3D images is newly designed.
- Trial name
- NCT04318171
- Testing
- 3D Imaging.
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Carotid Artery Stenosis Without Infarction (Disorder), Ischemic Stroke
Brachial Versus Femoral Access for Carotid Artery Stenting
Study purpose: A multicenter, prospective and randomized study is planned to compare the clinical outcomes of carotid artery stenting via brachial artery access and femoral artery access.
- Trial name
- BEFIT (NCT06557135)
- Testing
- Carotid Artery Stenting (CAS)
- Where
- China
- Volunteers
- 235 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Carotid Stenosis
Carotid Stenting in Patients With High Risk Carotid Stenosis ("Soft Plaque")
Stenting is an alternative to traditional surgery in the treatment of carotid stenosis.The intra and/or postprocedural cerebral embolization remains the most frequent complication.
- Trial name
- MOMA (NCT01274676)
- Testing
- carotid stenting with MOMA, Carotid stenting with filter wire EZ
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Centro Cardiologico Monzino
Arteriosclerosis
Investigation of Multiple Ultrasound Techniques for the Assessment of Carotid Plaque Vulnerability
Stroke is a common clinical disease with high disability and mortality, which seriously threatens human life and health.Carotid atherosclerotic plaque rupture is an important pathogenic basis of ischemic stroke, so judging the…
- Trial name
- NCT04530721
- Testing
- no intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carotid Stenosis
Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting
The purpose of this study is to evaluate the safety and efficacy of the TriActiv® ProGuard™ System when used during a stent placement in a blockage within the carotid artery in patients considered to be at high risk for…
- Trial name
- NCT00395785
- Testing
- Carotid Stent Implantation, Embolic Protection
- Where
- 34 sites in United States, Germany
- Volunteers
- 400 people
- Sponsor
- Kensey Nash Corporation
Atherosclerosis, Cardiovascular Diseases
Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome
To investigate whether women with Polycystic Ovary syndrome (PCOS) have evidence of an increased prevalence rate of subclinical atherosclerosis as measured by the presence of plaque, increased intima-medial carotid artery wall…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00005459
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Vascular Diseases, Peripheral Arterial Disease
Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery
The objective of this post-market clinical follow-up study is to evaluate the clinical outcomes of patients receiving PhotoFix as a patch within a vascular repair or reconstruction procedure.
- Conditions
- Vascular Diseases, Peripheral Arterial Disease, Hemodialysis Access Failure (Disorder), Carotid Artery Diseases
- Trial name
- PHOTO-V (NCT03669042)
- Testing
- PhotoFix
- Where
- 9 sites in United States
- Volunteers
- 94 people
- Sponsor
- Artivion Inc.
Hypertension, Carotid Stenosis
Reconstruction of the Carotid Bifurcation in Patients With Arterial Hypertension of 2-3 Degrees
Carotid endarterectomy (CEA) is a well-established procedure for preventing ischemic brain damage. Stenosis of the precerebral vessels are often combined with arterial hypertension.
- Conditions
- Hypertension, Carotid Stenosis, Symptomatic Carotid Artery Stenosis
- Trial name
- NCT05931003
- Testing
- Carotid stenting, Carotid endarterectomy
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Samara State Medical University
Carotid Artery Plaque, Diagnosis
Preoperative Identification of the Histologically "Vulnerable" Plaque Using Non-invasive Imaging, Biomechanical Assessment and Baroreflex Evaluation in Patients With Severe Carotid Stenosis
Carotid artery stenosis due to atherosclerotic plaques accounts for an important cause of ischemic stroke. Current research seeks to risk stratify asymptomatic patients by characterizing rupture-prone plaques.
- Trial name
- PREDICT (NCT05566080)
- Testing
- Carotid endarterectomy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Psoriatic Arthritis, Atherosclerosis
PsA T2T Statin Trial on Carotid and Coronary Atherosclerosis
Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with an increased risk of myocardial infarction (MI). Using coronary computer tomography angiogram (CCTA), it is found that a significantly higher prevalence…
- Trial name
- NCT04176978
- Testing
- Rosuvastatin, Treat-to-target strategy
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Carotid Artery Stenosis
PMCF Study of Precise Pro Rx for Carotid Artery Disease
The purpose of this study is to evaluate long-term clinical safety and performance of the PRECISE PRO RX Nitinol Stent System to treat stenotic lesions of the carotid arteries.
- Trial name
- REAL-PRECISE (NCT07204678)
- Testing
- PRECISE PRO Rx Nitinol Stent System
- Where
- 4 sites in Austria, France and 1 more
- Volunteers
- 199 people
- Sponsor
- Cordis US Corp.
Carotid Artery Stenosis, Head and Neck Cancer
Carotid Artery Stenosis and Ischemic Cerebrovascular Events After Radiotherapy in Patients With Head and Neck Cancer
The study had a cross-sectional design and included patients with HNC involving the oral cavity, pharynx, larynx, nasal cavity, or salivary glands who recieve RT.
- Conditions
- Carotid Artery Stenosis, Head and Neck Cancer, Radiation Therapy, Transient Ischemic Attack
- Trial name
- RT-CASinHNC (NCT06556979)
- Testing
- Radiotherapy
- Where
- Thailand
- Volunteers
- 907 people
- Sponsor
- Chulabhorn Royal Academy
Carotid Stenosis, Cardiovascular Disease
Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization
The combination of aspirin and dipyridamole, two antiplatelet drugs, is approved in Italy for the secondary prevention of cerebral embolism in patients with carotid atherosclerosis.
- Conditions
- Carotid Stenosis, Cardiovascular Disease, Atherosclerosis, Stroke
- Trial name
- ICAR (NCT02630862)
- Testing
- Aspirin, aspirin plus dipyridamole
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- University of Roma La Sapienza
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
Evaluation of Balloon Guide Catheter as Proximal Protection During Carotid Artery Stenting (EMBO-PROTECT)
Carotid angioplasty and stenting (CAS) is an effective treatment for carotid artery stenosis but carries a risk of cerebral embolization.
- Trial name
- EMBO-PROTECT (NCT07576790)
- Testing
- balloon guide catheter, No Proximal Protection Group
- Volunteers
- 126 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
End-stage Renal Disease, Hemodialysis
Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY)
This study aims to investigate the effects of high flux dialyser use and ultra pure dialysate utilization on cardiovascular disease by evaluating cardiovascular morbidity and mortality, progression of carotid artery intima-media…
- Trial name
- NCT00295191
- Testing
- high-flux membrane, low-flux membrane, conventional dialysate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 704 people
- Sponsor
- Ege University
Carotid Artery Stenosis, Carotid Artery Stenting
CAS for Stenosis With High-risk Features for CEA
The purpose of this prospective, multicenter, single-group target-value study is to evaluate the safety and efficacy of the carotid artery stent system in patients with high-risk features for carotid endarterectomy.
- Trial name
- HeartCare CAS (NCT07370246)
- Testing
- Carotid artery stent system
- Where
- 16 sites in China
- Volunteers
- 212 people
- Sponsor
- Beijing Tiantan Hospital