Clinical trials: Ocular Diseases
the Objective Diagnosis of Depression
A Multicentre Clinical Study
This study intends to conduct a multi-center, large-sample clinical trial, aiming at using multi-channel near-infrared spectroscopy to detect the characteristics of brain Oxy-Hb changes over time during cognitive activation in…
- Trial name
- NCT07062666
- Testing
- SSRIs, fNIRS
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Leber's Hereditary Optic Neuropathy
Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy
The study is a dose-escalation study, phase 1. The objective of this proposed clinical trial is to evaluate the safety of mitochondrially targeted ND4 gene therapy with the adeno-associated viral vector in appropriate LHON…
- Trial name
- LHON (NCT02161380)
- Testing
- injection of scAAV2-P1ND4v2 1.18x10e9 vg (Low),, injection of scAAV2-P1ND4v2 5.81 X10e9 vg (Med), injection of scAAV2-P1ND4v2 2.4 X10e10vg (High)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Byron Lam
Presbiyopi
Effect of Yoga Eye Exercises and Musculoskeletal Physiotherapy Interventions on Presbyopia
In this study, the effects of neck exercises, neck massage and yoga eye exercises on presbyopia will be examined. 52 patients diagnosed with presbyopia will be included in the study.
- Trial name
- NCT06729879
- Testing
- Yoga eye exercises group:, Myofascial release-postural correction exercises group, Yoga eye exercises, myofascial release-postural correction exercises group
- Volunteers
- 52 people
- Sponsor
- Tokat Gaziosmanpasa University
Proliferative Diabetic Retinopathy
Changes in Vitreous Temperature During Phacoemulsification
Temperature in the vitreous cavity decreases during vitrectomy, and the same effect is seen during an uneventful phaco surgery. Significant changes occur between the baseline temperature and after every step of the surgery.
- Trial name
- NCT01568242
- Testing
- Phacoemlsification
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Cataract
Safety and Efficacy of a Novel Hydrophobic Acrylic IOL - iPure: a Randomised Study
In this study the rotational stability and performance - with respect to glistening and PCO formation - of a new hydrophobic acrylic IOL (IPure, PhysIOL, Belgium) will be compared to a gold standard IOL (AMO ZCB00) in a…
- Trial name
- NCT04329754
- Testing
- Cataract surgery
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Stroke, Neglect, Hemispatial
Head Mount Display-based Virtual Reality Rehabilitation of Hemispatial Neglect
Head-mounted display based virtual reality rehabilitation for hemispatial neglect.
- Trial name
- NCT03463122
- Testing
- field of regard-focused visual exploration therapy, conventional therapy
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- National Rehabilitation Center, Seoul, Korea
Dry Eye Disease
Evaluation of the Safety and Tolerability of Ocular Lubricants
The purpose of this study is to evaluate the safety and tolerability of three new artificial tear formulations in subjects with moderate dry eye disease.
- Trial name
- NCT06571656
- Testing
- FID123359 test formulation, FID123360 test formulation, FID123361 test formulation
- Where
- 5 sites in Australia
- Volunteers
- 73 people
- Sponsor
- Alcon Research
Myopia, Myopia, Progressive
Study to Evaluate the Efficacy of Alleance® (Atropine Sulfate 0.01%) as a Treatment to Delay Myopia and Axial Ocular Elongation in Children.
Phase III clinical study to evaluate the efficacy of Alleance® (atropine sulfate 0.01%) ophthalmic solution through the incidence of unexpected adverse events, changes in Best Corrected Visual Acuity (BCVA), changes in…
- Trial name
- NCT06389110
- Testing
- Alleance®
- Where
- Mexico
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Diabetes Mellitus, Diabetic Retinopathy
Serum GPER-1 and Oxidant/Antioxidant Levels on Retinopathy in Diabetic Patients
Observational, comparative, cross-sectional study
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Hormones
- Trial name
- NCT04930224
- Testing
- The effect of GPER-1 on the formation of diabetic retinopathy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Hypertension, Hypoxia
The VISION-Acute Study
AIM: We propose an innovative approach using Lifelight® smart technology that will enable the continued provision of high level patient care at the same time as reducing pressure on nursing and equipment resources.
- Conditions
- Hypertension, Hypoxia, Hypotension
- Trial name
- NCT04589923
- Testing
- Lifelight® Data Collect Blood Pressure Group, Lifelight® Data Collect Oxygen Saturation Group
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Xim Limited
Glaucoma Open-Angle Primary, Pseudo Exfoliation Syndrome
Monitoring of the IOP After SLT Using iCare Home
The purpose of this study is to investigate how much selective trabeculoplasty (SLT) influences intraocular pressure (IOP) fluctuations measured with iCare Home rebound tonometry (RTHome) in patients with primary open-angle…
- Trial name
- NCT03310788
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- St. Erik Eye Hospital
Brain and Central Nervous System Tumors
VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as VNP40101M, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00098761
- Testing
- laromustine
- Where
- 10 sites in United States
- Volunteers
- 42 people
- Sponsor
- Pediatric Brain Tumor Consortium
Cataract
A Comparison of the Diagnostic Confidence and Image Quality Between the Eyoto Theia (RDSL) and a Predicate Device.
A clinical study has been identified as a requirement for the RDSL (Theia). This study involves a clinical comparison of the imaging from the RDSL with that of a predicate device.
- Trial name
- NCT05783583
- Testing
- Remote Digital Slit Lamp
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eyoto Group Ltd
Cataract
Multifunctional Cataract Surgery Assistive Instruments Used in Cataract Surgery
In order to better cope with complex situations of cataract surgery, we designed and improved a new set of multi-functional cataract surgery auxiliary devices, including ophthalmic surgery auxiliary hooks, eye retractor hooks and…
- Trial name
- NCT06182605
- Testing
- multifunctional instruments, traditional instruments
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes (DM), Prediabetes
Artificial-Intelligence-based Early Detection of Diabetic Retinopathy (FUNDUS AI)
Examination of individuals with prediabetes and established diabetes for early signs of diabetic retinopathy.
- Trial name
- FUNDUS AI (NCT07378891)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Ophthalmoplegia
Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia
Oculomotor nerve (third cranial nerve or III) palsy is a relatively frequent cause of consultation in ophthalmology. It may reveal a life-threatening pathology such as aneurysm rupture, pituitary apoplexy, and therefore need…
- Trial name
- HYPER-III (NCT03135574)
- Testing
- MRI T2 sequence of the oculomotor tract
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Progressive Supranuclear Palsy, Cognitive Impairment
Neuropsychological Evaluation for Early Diagnosis of PSP
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
- Trial name
- NCT03478124
- Testing
- Cognitive evaluation
- Volunteers
- 112 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Graves Ophthalmopathy
Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy
The goal of this interventional study is to compare the effectiveness of two different glucocorticoid regimens for treatment of active moderate-to-severe Graves' orbitopathy. The main questions it aims to answer are: 1.
- Trial name
- NCT05793359
- Testing
- Methylprednisolone
- Where
- Bulgaria
- Volunteers
- 62 people
- Sponsor
- Medical University of Sofia
Dry Eye Syndromes
Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04413279
- Testing
- LipiFlow Thermal Pulsation, Dexamethasone Intracanalicular Insert, 0.4mg with LipiFlow Thermal Pulsation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eye Surgeons of Indiana
Autism, Intellectual Disabilities
Online Video Training for Teachers to Improve Reading Skills in Children Using Augmentative and Alternative Communication
The aim of this study is to investigate , via a randomized control trial (RCT), the effectiveness of an online video training platform designed for teachers to support the improvement of basic reading skills of children with…
- Trial name
- NCT06766188
- Testing
- Online Video training for Teachers based on Reading for all
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Ostfold University College
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