Clinical trials: Ocular Pathologies
Blindness, Visual Impairment
iReach: a Rehabilitative Medical Device
The broad goal of this clinical trial is to demonstrate whether a one-month rehabilitative training with our medical device, iReach, can promote the recovery of spatial and sensorimotor abilities and the cortical reorganization…
- Trial name
- NCT06334614
- Testing
- iReach
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istituto Italiano di Tecnologia
Epiretinal Membrane, Retinal Hemorrhage
Robotic Retinal Dissection Device Trial
The purpose of the study is to determine whether use of a robotic system improves the precision and therefore safety of high precision steps in retinal surgery.
- Trial name
- R2D2 (NCT03052881)
- Testing
- Robot assisted surgery
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity: A Pilot Study
The goal of this observational study is to investigate whether differences in oral proprioceptive sensitivity are associated with differences in kinesthetic acuity of the upper limbs in children.
- Trial name
- NCT07854314
- Testing
- Upper-Limb Kinesthetic Acuity Assessment, Effect of Auditory Stimulation on Visual Perception, Oral Proprioceptive Sensitivity Assessment
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sophie Román Richon
Subjects Presenting With Normal or With Ocular Pathology
Clinical Validation of New OCT System
To demonstrate clinical substantial equivalence of DRI OCT-1 as comparable to the commercially available Cirrus
- Trial name
- NCT01809704
- Where
- 3 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Opioid Toxicity, Pupillary Miosis
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60.
- Conditions
- Opioid Toxicity, Pupillary Miosis, Respiratory Depression
- Trial name
- NCT05391555
- Testing
- Remifentanil Hydrochloride, Pupillometry measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Zika, Neurodevelopmental Abnormality
International Cohort Study of Children Born to Women Infected With Zika Virus During Pregnancy
The International Cohort Study of Children Born to Women Infected with Zika Virus (ZIKV) During Pregnancy study is a prospective, observational, international cohort study of children previously enrolled in the ZIP study or other…
- Conditions
- Zika, Neurodevelopmental Abnormality, Hearing Loss, Growth Delay
- Trial name
- NCT04118738
- Where
- 5 sites in Brazil, Colombia and 2 more
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Westat
Stroke
Upper Limb Function and Visuospatial Exploration After Stroke
This project is a cross-sectional, observational mono-center study with prospective data collecting. This study aims to further explore quality of upper limb movement in relation to characteristics of visuospatial exploration in…
- Trial name
- NCT03135093
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Amblyopia
Plasma Biomarker in Amblyopia Patients
This prospective study aims to observe the predictive effect of peripheral blood plasma biomarker on the outcome of treatment in children with different types of amblyopia.
- Trial name
- NCT05705778
- Testing
- standard amblyopia treatment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Age Related Macular Degeneration
Use of Self-management Group to Improve Quality of Life in Patients With Low Vision
120 Patients with visual acuity <6/12 will be randomized to receive either usual care or participate in a 6-week, 2 hour 'Living with Vision Loss' program led by trained leaders.
- Trial name
- NCT03046485
- Testing
- Self management program 'Living with Vision Loss'
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Presbyopia, Low Vision
Ocular Biomarkers for Successful Premium Trifocal Intra-ocular Lenses Implantation
The purpose of this study is to identify ocular biomarkers that can predict the success of phacoemulsification with bilateral AT LISA try 839MP (Carl Zeiss Meditec AG) implantation to achieve satisfactory post-post-operativly…
- Trial name
- NCT05863247
- Testing
- Patient Reported Outcomes / Biometric data revision
- Where
- Portugal
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Hospital dos Lusíadas
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Sepsis, Retinal Microcirculation Disorder
Ocular Microvascular Changes in Patients With Sepsis
This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic…
- Conditions
- Sepsis, Retinal Microcirculation Disorder, Conjunctiva; Disorder
- Trial name
- NCT04214743
- Testing
- Incident dark field videomicroscope from Braedius, Fundus camera from Optomed
- Where
- Lithuania
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Inflammation, Sjogren's Syndrome
Superb Microvascular Imaging Ultrasonography of Lacrimal Gland in Patients With Sjögren Syndrome
A prospective study will be conducted to evaluate inflammatory activity in lacrimal glands due to Sjögren's syndrome on Superb Microvascular Imaging (SMI), gray scale ultrasound (US), color Doppler US and Power Doppler US.
- Conditions
- Inflammation, Sjogren's Syndrome, Gland; Inflammation
- Trial name
- SMI (NCT05689749)
- Testing
- Superb Microvascular Imaging (SMI) (Toshiba)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
CADASIL, Cavernous Angioma
Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2
CERVCO is the French National Reference Centre for Rare Cerebrovascular and Retinal Diseases, accredited by the Ministry of Health since 2005.
- Conditions
- CADASIL, Cavernous Angioma, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Small Vessel Disease
- Trial name
- B-MRVC2 (NCT07650110)
- Testing
- Biocollection, Neurological evaluation and Biocollection
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glaucoma Patients, Retina Patients
Performance Evaluation of Dream OCT: AP Study
This study will evaluate the clinical performance of a new swept-source OCT imaging device, the VG200D, and to evaluate substantial equivalence with a predicate device, the Cirrus 5000.
- Conditions
- Glaucoma Patients, Retina Patients, Eyes With Corneal Abnormality, Normal Healthy Eyes
- Trial name
- NCT07355491
- Testing
- This is an observational study only, all patients are imaged on the investigational device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Intalight, Inc
Healthy, Glaucoma
Clinical Validation Study of RTVue Features
To perform a clinical validation study of RTVue features in volunteers with various ocular pathology or no ocular pathology.
- Trial name
- NCT01370850
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Optovue
Malnutrition, Diabetes
Efficacy of Zinc Fortified Fermented Wheat Flour
Zinc is a pivotal micronutrient that participates in numerous essential metabolic pathways within the human body. Its multifaceted role makes the manifestations of zinc deficiency remarkably nonspecific and age-dependent.
- Conditions
- Malnutrition, Diabetes, Inflammation, Conjunctivitis
- Trial name
- EZAFFAW (NCT06092515)
- Testing
- Fermented High Zinc Wheat Flour Flatbread, Unfermented High Zinc Wheat Flour Flatbread, Post-Harvest Fortified Whole Wheat Flour Flatbread
- Where
- Pakistan
- Volunteers
- 1,044 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Cataract
Outcomes of Phacoemulsification With Torsional Ultrasound
To determine the differences in intra-operative complications, surgical duration, fluid usage, corneal thickness and endothelium cell density in eyes undergoing microcoaxial phacoemulsification (MCP) either with Torsional or…
- Trial name
- NCT01010490
- Testing
- Torsional ultrasound (INFINITI, Alcon, USA), Longitudinal U/S (Infiniti system, Alcon, USA), Longitudinal U/S (LEGACY 20000, Alcon, USA)
- Where
- India
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Iladevi Cataract and IOL Research Center
Obstructive Sleep Apnoea, Primary Open Angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 1
Lowering of the pressure in the eye (intraocular pressure, IOP) is the only proven treatment for Primary Open-angle Glaucoma (POAG).
- Trial name
- PAIR (NCT03127813)
- Testing
- Application of continuous positive airway pressure (CPAP)
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Diabetic Retinopathy, Neurodegeneration
Retinal Neurodegenerative and Vascular Changes in Diabetic Patients
Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with…
- Trial name
- NCT04637217
- Testing
- Optical Coherence Tomography
- Where
- Romania
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy