Clinical trials: Oesophagectomy
Esophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)
Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients
Brief Summary This clinical trial aims to evaluate whether perioperative goal-directed fluid therapy (GDFT) targeting a venous excess ultrasound (VExUS) score of 1 can reduce postoperative pulmonary complications (PPCs) in…
- Trial name
- NCT07691944
- Testing
- VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
- Volunteers
- 126 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Barrett's Esophagus, Esophageal Cancer
Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium
The purpose of this study is to evaluate a cryoablation technique used to ablate human esophageal mucosa.
- Trial name
- NCT01293448
- Testing
- Cryoballoon Ablation
- Where
- 4 sites in United States, Netherlands
- Volunteers
- 21 people
- Sponsor
- Pentax Medical
Esophageal Neoplasms
Mediastinoscopy-assisted Transhiatal Esophagectomy Versus Thoraco-laparoscopic Esophagectomy for Esophageal Cancer
Esophageal cancer is one of the major diseases that seriously threatens an individual's health and life. To reduce the incidence of postoperative complications and mortality of esophageal cancer, thoraco-laparoscopic…
- Trial name
- NCT04125849
- Testing
- Thoraco-laparoscopic esophagectomy, Mediastinoscopy-assisted transhiatal esophagectomy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Gastrectomy, Oesophagectomy
Metabolic Consequences of Gastrointestinal Surgery
Surgery on the gastrointestinal (GI) tract results in profound changes to the metabolic profile. This is well described, including the rapid resolution of diabetes seen after bariatric surgery.
- Conditions
- Gastrectomy, Oesophagectomy, Dumping Syndrome, Hypoglycaemia
- Trial name
- MaS (NCT02836353)
- Testing
- Somatostatin, Rifaximin
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Esophageal Neoplasms
Esophagectomy:Three-field Versus Two-field Lymphadenectomy (ECTOP-2002)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-2002. Esophageal carcinoma is an aggressive disease with a poor prognosis.
- Trial name
- NCT01807936
- Testing
- Lymphadenectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fudan University
Esophageal Cancer, Adenocarcinoma
Evaluate Mesothelin as a Biomarker for the Clinical Management of Esophageal Adenocarcinoma (EAC)
The purpose of this study is to find out whether a protein, called mesothelin, found in the blood and tissue can be used as "marker" for esophageal cancer.
- Trial name
- NCT01393483
- Testing
- serum and tissue mesothelin
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Esophageal Cancer
Sentinel Lymph Node Mapping in Esophageal Cancer Using ICG Dye and NIR Imaging
The purpose of this study is to find out whether sentinel lymph node (SLN) mapping with ICG dye and NIR imaging can be used to identify esophageal or esophagogastric junction cancer that has spread to the lymph nodes.
- Trial name
- NCT04400292
- Testing
- Injection of indocyanine green (ICG)dye, Near-Infrared Image-Guided, Sentinel Lymph Node (SLN) mapping
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Esophageal Cancer, Gastroesophageal Junction Cancer
Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.
The primary objective is to evaluate the efficacy and assess the role of Porcine Fibrin Sealant (Bioseal®) in preventing cervical anastomotic leakage after esophagectomy in the patients with resectable thoracic esophageal cancer…
- Conditions
- Esophageal Cancer, Gastroesophageal Junction Cancer, Anastomotic Leak
- Trial name
- PLACE020 (NCT03529266)
- Testing
- Porcine Fibrin Sealant (PFS), Surgery
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Esophageal Neoplasms, Esophagectomy
Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)
Esophagectomy is the cornerstone of the curative treatment of esophageal carcinoma. Despite this treatment, patients can suffer from locoregional or distant metastatic disease and only a very selected group of patients can be…
- Conditions
- Esophageal Neoplasms, Esophagectomy, Brain Metastases
- Trial name
- METABREC (NCT04654975)
- Testing
- Esophagectomy for esophageal cancer
- Where
- 8 sites in United States, Belgium and 4 more
- Volunteers
- 10,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Cancer, Nutrition Disorders
Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery
The incidence of oesophagogastric cancer has increased by 400% since the 1970s in Ireland and the United Kingdom. In addition, refinement of perioperative management and the now widespread use of multimodal protocols for patients…
- Conditions
- Esophageal Cancer, Nutrition Disorders, Appetite Disorders, Dumping Syndrome
- Trial name
- EndoGut (NCT03734627)
- Testing
- Octreotide Acetate, Saline Solution, Paracetamol
- Where
- 2 sites in Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Cancer, Squamous Cell Carcinoma
Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases
There is no world-wide consensus on the oncological benefit versus increased morbidity associated with three field lymphadenectomy in patients with esophageal cancer and cervical lymph node metastases.
- Conditions
- Cancer, Squamous Cell Carcinoma, Adenocarcinoma, Malignancy
- Trial name
- Node (NCT02426879)
- Testing
- esophagectomy with three-field lymphnode dissection
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Detection Rate of SLN ; Accuracy Rate of Lymph Node Metastasis
Sentinel Lymph Node Navigation Surgery Using Near-infrared Imaging in Early Esophageal Cancer
The esophageal squamous cell carcinoma (ESCC) has high prevalence and mortality in China, which become a severe challenge for public health.
- Trial name
- NCT04173676
- Testing
- Indocyanine Green for Injection
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Esophageal Cancer
Visualization Versus Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerves During Thoracoscopic Esophagectomy
The clinical value of intraoperative nerve monitoring (IONM) in thoracoscopic esophagectomy remains uncertain. The aim of this randomized clinical trial was to compare the impact of RLN visualization versus IONM on their…
- Trial name
- NCT05199168
- Testing
- intraoperative nerve monitoring
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Esophageal Neoplasms, Carcinoma, Squamous Cell
A Trial of Chemotherapy Before and After Surgery for Stage II,III Esophageal Squamous Cell Carcinoma
To determine whether chemotherapy before surgery makes better outcome than chemotherapy after surgery in patients with esophageal squamous cell carcinoma
- Trial name
- NCT00190554
- Testing
- Surgery +(Cisplatin 80 mg/㎡+5FU 800mg/㎡×5days)×2, (Cisplatin 80 mg/㎡+5FU 800mg/㎡×5days)×2＋Surgery
- Where
- 24 sites in Japan
- Volunteers
- 330 people
- Sponsor
- Japan Clinical Oncology Group
Esophageal Cancer
Quality of Life Outcomes Following Minimally Invasive and Open Esophagectomy for Esophageal Cancer
The goal of this study is to evaluate how surgery for esophageal cancer affects the patient's quality of life over time. The investigators hope this study will provide important information that can be used to improve the quality…
- Trial name
- NCT01558648
- Testing
- Quality of Life instruments, FACT-E, Symptom Assessment Scale, Brief Pain Inventory and Daily Analgesic Log
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Esophageal Cancers
Surgery or Chemoradiation for Esophageal Cancer
The aim of this study is to compare outcomes in patients with operable squamous carcinoma of the esophagus who have received either surgery or definitive chemoradiation (CRT).
- Trial name
- NCT01032967
- Testing
- Esophagectomy, Definitive chemoradiation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Esophageal Cancer
Esophagectomy With or Without Prior Ischemic Gastric Preconditioning
This multi-center, randomized prospective clinical trial involves esophageal cancer patients who are surgical candidates. Patients will be randomized either to the one stage or the two stage esophagectomy procedure.
- Trial name
- NCT02457299
- Testing
- Two Stage Esophagectomy, One Stage Esophagectomy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Endeavor Health
Esophagus Cancer, Gastric Cancer
Predictive Model to Early Diagnosis of Anastomotic Leak After Esophagectomy and Gastrectomy.
The PROFUGO study (PRedictive Model for the early diagnosis of anastomotic leak after esophagectomy and gastrectomy) is proposed as a prospective and multicenter study at spanish national level that aims to develop, with the help…
- Conditions
- Esophagus Cancer, Gastric Cancer, Leak, Anastomotic, Complication
- Trial name
- PROFUGO (NCT05390684)
- Testing
- audit of complications, prospective data collection
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- Hospital Universitario La Fe
Esophageal Neoplasms
Nutritional Route In Esophageal Resection Trial II
The aim of this study is to investigate the effects of early start versus delayed start of oral intake on postoperative functional recovery after an esophagectomy.
- Trial name
- NUTRIENTII (NCT02378948)
- Testing
- Liquid oral feeding
- Where
- 2 sites in Netherlands
- Volunteers
- 148 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Esophageal Cancer, Exercise Training
Development and Initial Application of a Combined Exercise and Psychological Intervention Program for Patients After Esophagectomy
Esophageal cancer imposes a significant burden in China, accounting for over 60% of the global disease burden. While surgery remains a common and highly effective treatment for esophageal cancer, patients often experience…
- Conditions
- Esophageal Cancer, Exercise Training, Psychotherapy, Rehabilitation
- Trial name
- Recovery (NCT06366685)
- Testing
- Exercise and Psychological Intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Mengmeng Yuan