Clinical trials: Old Age; Dementia
Parkinson Disease Dementia
Neuropsychological Assessment of Cognitive Decline in Patients With a Definite Parkinson's Disease
Cognitive disorders in Parkinson's disease (PD) are not as obvious as cognitive disorders in Alzheimer disease and their diagnosis tends to be delayed.
- Trial name
- NCT01113242
- Testing
- Neuropsychological Assessment
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Frail Elderly
Cognitive Function and Prevalence of Amyloid Marker in Frail Older Adults
The current study seeks to examine the prevalence of amyloid pathology, among patients referred to the Toulouse Geriatric Frailty Clinic presenting objective memory impairment.
- Trial name
- COGFRAIL (NCT03129269)
- Testing
- MRI and PET scan
- Where
- France
- Volunteers
- 344 people
- Sponsor
- University Hospital, Toulouse
Alzheimer Disease
Quality of the Management of Diabetes in Elderly People With Dementia in France
Along with population ageing, the association of chronic conditions such as Alzheimer's Disease and Related Syndromes (ADRS) and diabetes mellitus is increasing in clinical practice.
- Trial name
- DIA-FRADEM (NCT03565809)
- Testing
- Incidence analysis
- Where
- France
- Volunteers
- 87,816 people
- Sponsor
- University Hospital, Toulouse
Mild Cognitive Impairment, Age-associated Memory Impairment
Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia, characterized by memory deficits without functional impairment.
- Trial name
- NCT05934344
- Testing
- Action observation training
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Diabetes, Senile Dementia, Alzheimer Type
A Study of Mobile Medical Supportive Care Program for Family Caregivers With Dementia Combined With Diabetes
The purpose of this project is to evaluate the effectiveness of the clinical application of a mHealth supportive care program for family caregivers with dementia combined with diabetes based on the supportive care framework.
- Trial name
- NCT06785857
- Testing
- mHealth Supportive Care Program, Offline supportive care
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Chewing Problem, Cognitive Decline
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
Today in elderly tooth loss and loss of oral function is widespread, but it is an underexplored modifiable risk factor potentially contributing to the development of dementia.
- Conditions
- Chewing Problem, Cognitive Decline, Magnetic Resonance Imaging, Degenerative; Dementia
- Trial name
- NCT04458207
- Testing
- Oral prosthetic rehabilitation
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Folktandvården Stockholms län AB
Alzheimer's Disease
Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy
The study will include a preliminary pharmacokinetics (PK) / safety / tolerability evaluation in healthy elderly subjects followed by the Receptor Occupancy (RO) evaluations in healthy elderly subjects and in Alzheimer's Disease…
- Trial name
- NCT00499200
- Testing
- SRA-444
- Where
- Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Dementia, Oral Hygiene
Oral Health, Bite Force and Dementia
Study aims: The primary aim is to identify influencing variables on oral hygiene / oral health and bite force in patients with dementia.
- Conditions
- Dementia, Oral Hygiene, Chewing Problem
- Trial name
- OrBiD (NCT03775772)
- Testing
- Oral Health, Bite Force
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Alzheimer's Disease
A Phase III Trial of Nilvadipine to Treat Alzheimer's Disease
Alzheimer's disease (AD) is an ever-increasing public health concern among the aging population and is the most common form of dementia affecting more than 15 million individuals worldwide and around 5 million Europeans.
- Trial name
- NILVAD (NCT02017340)
- Testing
- Nilvadipine
- Where
- 23 sites in France, Germany and 7 more
- Volunteers
- 511 people
- Sponsor
- Prof Brian Lawlor
Prion Disease, Dementia
Enhanced CJD Surveillance in the Older Population
The purpose of this study to investigate if cases of Creutzfeldt-Jakob Disease (CJD) and other forms of prion disease are being missed in older adults living within Lothian.
- Trial name
- NCT02629640
- Testing
- Medical history questionnaire, Clinical assessment and review, Participant follow-up
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Alzheimer Dementia
Comparison of Dual Assignment, Cadence, and Gait Speed in Alzheimer's Dementia and Healthy Geriatric Individuals
Tests will be performed in individuals with Alzheimer's dementia to compare dual-task and gait with healthy geriatric individuals.
- Trial name
- NCT05767580
- Testing
- evaluation
- Volunteers
- 50 people
- Sponsor
- Kırıkkale University
Covid19, Death
COVID-19 Infections and Mortality in Long-term Care Facilities During the First Wave
The medical charts of all COVID-19 cases (n=1200) from 17 long-term care facilities in Montreal, Canada will be reviewed, to compare patients who survived to patients who did not survive.
- Conditions
- Covid19, Death, Infection Viral, Infections, Respiratory
- Trial name
- NCT04782427
- Testing
- COVID-19 infection
- Where
- Canada
- Volunteers
- 1,197 people, healthy volunteers welcome
- Sponsor
- Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Alzheimer's Disease
Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease
Alzheimer's disease is a medical illness that damages the brain and causes problems with memory, mood and behavior. A substance called acetylcholine (ACh), which is naturally produced in the body, plays an important role in the…
- Trial name
- NCT00104442
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Novartis
Dementia, Femur Fracture
Care of Older People With Cognitive Impairment or Dementia Hospitalized in Traumatology Units
This is a quasi-experimental design with repeated observations, taken at baseline, post-intervention, and at one and three months post-intervention.
- Conditions
- Dementia, Femur Fracture, Continuity of Patient Care
- Trial name
- CARExDEM (NCT04048980)
- Testing
- CARExDEM
- Where
- Spain
- Volunteers
- 432 people
- Sponsor
- Hospital Clinic of Barcelona
Dementia, Depression
Geriatric Psychiatry and Pharmacovigilance
The purpose of this observational multicenter-study is to investigate safety of psychopharmacological treatment and rates of adverse drug reactions in gerontopsychiatric inpatients.
- Conditions
- Dementia, Depression, Schizophrenia, Psychosomatic Disorders
- Trial name
- GAP (NCT01858857)
- Where
- 5 sites in Germany
- Volunteers
- 4,000 people
- Sponsor
- Hannover Medical School
Neurocognitive Deficit
Concordance Between Mini-Mental Stats Examination (MMSE) and an Adapted Version of the MMSE in Reunion Island Population (MMS-Run)
Illeteracy concerns more than 38% of Réunion Island's people older than 65 years old, which makes it an important risk factor for dementia and a limit to neurocognitive test's administration.
- Trial name
- MMS-R-ep (NCT05858489)
- Testing
- Mini-Mental State Examination (MMSE)
- Where
- Reunion
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Alzheimer Disease
A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease: Implementation Phase 2
Potentially inappropriate prescribing includes the use of medications that may no longer be necessary or that may increase the risk of harm.
- Trial name
- DPRESCRIBE-AD2 (NCT06368115)
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 11,375 people
- Sponsor
- University of Massachusetts, Worcester
Mild Cognitive Impairment
ENHANCING PHYSICAL and COGNITIVE EFFICIENCY in INDIVIDUALS AT RISK of DEMENTIA USING WHOLE-BODY ELECTROMYOSTIMULATION
This study aimed to evaluate the effectiveness of twelve weeks whole-body electrical muscle stimulation combined with aerobic exercises.
- Trial name
- NCT06669598
- Testing
- Whole Body Electromyostimulation, control group
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Molise
Delirium, Dementia, Amnestic, Cognitive Disorders, Memory Disorders
The Effects and Cost-Effectiveness of an Integrated Multidisciplinary Approach for Psychogeriatric Patients
The purpose of this study is to determine the effects and cost-effectiveness of a Diagnostic Observation Center for PsychoGeriatric patients (DOC-PG).
- Trial name
- NCT00402311
- Testing
- DOC-PG: integrated multidisciplinary assessment, Usual care: assessment by GP or one of the regional services
- Where
- Netherlands
- Volunteers
- 216 people
- Sponsor
- Maastricht University Medical Center