Clinical trials: Older
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Geriatric Oncology, Supportive Care
The GOS-Frail (Geriatric Oncology Supportive Care for Frail Older Adults With Cancer) Study
Background Cancer is more prevalent in older adults, but most cancer treatment trials have mainly involved young and healthy subjects.
- Conditions
- Geriatric Oncology, Supportive Care, Quality of Life
- Trial name
- GOS-Frail (NCT06553378)
- Testing
- Geriatric Oncology Supportive Clinic
- Where
- Singapore
- Volunteers
- 154 people
- Sponsor
- Tan Tock Seng Hospital
ELDERLY PEOPLE, Cognitive-motor Dual-task
The Effects of Cognitive-motor Dual-task Intervention on Fall Prevention Among Older Adults
1. Develop an evidence-based dual-task intervention programme incorporating gamification for fall risk reduction in older adults. 2. Examine the effects of the gamified dual-task intervention on fall risk in older adults. 3.
- Conditions
- ELDERLY PEOPLE, Cognitive-motor Dual-task, Fall Prevention, Intervention
- Trial name
- NCT07025278
- Testing
- Medium difficulty fixed priority group, Medium difficulty variable priority group
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Jinyao Wang
Aged
Electrical Stimulation in Older Adults
Within the problems associated with population aging and its morbidities, the musculoskeletal system is involved in detrimental changes, compromising, in many cases, the functional capacity of the patient and their correct…
- Trial name
- NCT06046885
- Testing
- Neuromuscular electrical stimulation
- Where
- Argentina
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario
Physical Disability, Cognitive Dysfunction
Study on Cardiovascular Health, Nutrition and Physical Functioning in Older Adults in Spain
Population aging makes it necessary to identify factors related to unhealthy aging. The purpose of this study is to examine the association between ideal cardiovascular health, diet and other lifestyles and biological risk…
- Trial name
- Sen-ENRICAII (NCT03541135)
- Where
- Spain
- Volunteers
- 4,000 people
- Sponsor
- Universidad Autonoma de Madrid
Older Adults Institutionalized in Residential Homes
A Virtual Reality Program for Nursing Home Residents With Physical Disabilities
This project will evaluate how well the immersive virtual reality psychological program works in residential care homes and how it can be used in everyday practice.
- Trial name
- NCT07879677
- Testing
- Psychological intervention
- Volunteers
- 400 people
- Sponsor
- Tung Wah College
Chronic Disease
A Mobile Intervention Merging Yoga and Self-Management Skills
Chronic disease self-management interventions and meditative movement approaches (.e.g., yoga) can independently improve depressive symptoms.
- Trial name
- MYSkillsMobile (NCT04758312)
- Testing
- MY-Skills Mobile
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Genetics, Metabolism and Weight Loss in Older, Obese Veterans
This study is designed to determine whether sequence variation in the lipoprotein lipase (LPQ) gene affects the amount of weight loss and metabolic responses during a hypocaloric diet treatment for overweight and obese (BMI=25-35…
- Trial name
- NCT00018330
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Acute Myeloid Leukemia
Bioequivalence of Daunorubicin Cytarabine Liposomes in Naive AML Patients
A Randomized, Double-blind, Multiple-Dose, Two-Cycle, Parallel-Group, Bioequivalence pretrial of Daunorubicin Cytarabine liposome for Injection in older, naive patients with Acute Myeloid Leukemia (AML).
- Trial name
- NCT04920500
- Testing
- Daunorubicin Cytarabine liposome for injection, Vyxeos、Daunorubicin Cytarabine liposome for injection
- Where
- China
- Volunteers
- 16 people
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Depression
Folic Acid and Omega -3 Fatty Acid Supplementation in Depressed Older Adults
Our specific aim is to determine the impact of folic acid and omega-3 supplementation on the severity of depressive symptoms among depressed adults aged 65 and above.
- Trial name
- NCT00480207
- Testing
- folic acid, omega-3, vit B12
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Prof. RH Belmaker
Health Behavior
Study the Impact of the CommunityRx Program on Health, Self-care and Cost
CommunityRx is a health information technology-based innovation that, starting with the patient-health care provider encounter, facilitates self-care coordination for patients, caregivers, and providers.
- Trial name
- NCT02435511
- Testing
- HealtheRx
- Where
- United States
- Volunteers
- 411 people
- Sponsor
- University of Chicago
Physical Fitness and Balance in Older Adults
The Relationships Between Physical Fitness and Static and Dynamic Balance in Geriatric Individuals
This study looked at the relationship between physical fitness and balance in older adults aged 65 years and over. Balance problems are common in older people and can increase the risk of falls and injuries.
- Trial name
- NCT07429877
- Testing
- No Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study
This clinical trial tests whether a geriatric optimization plan (GO!) works to improve survival in patients over 60 with a hematologic malignancy or bone marrow failure syndrome eligible for allogeneic hematopoietic cell…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Aplastic Anemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT05972577
- Testing
- Health Promotion and Education, Medical Device Usage and Evaluation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Health Self-management
Application of Health Empowerment Theory to Enhance Health Empowerment Levels and Self-Health Management Ability Among Older Migrants: A Randomized Controlled Trial
This study aimed to evaluate the effectiveness of a theory-based health self-management program in empowering older migrants to manage their health. This study used a single-blind, randomized controlled trial design.
- Trial name
- NCT06914739
- Testing
- The Health Empowerment Theory (HET) program, routine community care
- Where
- China
- Volunteers
- 66 people
- Sponsor
- TianLe Xiang
Cystic Fibrosis
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor
This is a Phase 3, randomized, double blind, placebo controlled, parallel group, multicenter study in people with cystic fibrosis (CF) who are homozygous for the F508del CF transmembrane conductance regulator (CFTR) gene mutation.
- Trial name
- NCT02347657
- Testing
- VX-661 Plus Ivacaftor Combination, Ivacaftor
- Where
- 74 sites in United States, Canada and 10 more
- Volunteers
- 510 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cardiovascular Diseases, Heart Diseases
Reducing Adverse Self-Medication Behaviors in Older Adults With Hypertension
The purpose of this study is to reduce adverse self-medication practices in older adults with hypertension.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00201201
- Testing
- Education Intervention, Control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Connecticut
Sarcopenia, Aging
Dual-benefits of Aerobic and Resistance Training
This study evaluates the effect of three different exercise strategies on physical function in older adults. Participants will be randomly assigned to one of three exercise groups: resistance training, moderate-intensity…
- Conditions
- Sarcopenia, Aging, Disability Physical
- Trial name
- DART (NCT03978572)
- Testing
- Resistance Training, Moderate-Intensity Continuous Cycling, High-Intensity Interval Cycling
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio University
Cognitive Impairment, Dementia
Anticipating Decline and Providing Therapy
This pilot feasibility study will be a randomized control trial of usual care following Intensive Care Unit (ICU) discharge compared to the Anticipating Decline and Providing Therapy (ADAPT) screening and support intervention.
- Conditions
- Cognitive Impairment, Dementia, Post ICU Syndrome, Critical Illness
- Trial name
- ADAPT (NCT06182995)
- Testing
- Usual Care post-Intensive Care Unit (ICU), Anticipating Decline and Providing Therapy (ADAPT)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Wake Forest University Health Sciences
Cognition, Affect (Mental Function)
BiomeBakery Project
This study aims to investigate the chronic effects of prebiotic fibre-fortified functional bakery product on cognitive, affective, inflammatory, metabolic, and anthropometric outcomes in healthy adults aged 60-75 years with mild…
- Conditions
- Cognition, Affect (Mental Function), C Reactive Protein
- Trial name
- NCT06796712
- Testing
- Prebiotic fibre fortified bread roll, Regular bread roll
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cognitive/Functional Effects, Colorectal Cancer
Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
This randomized phase III trial studies how well combination chemotherapy plus bevacizumab with or without oxaliplatin works in treating older patients with colorectal cancer that has spread to other places in the body.
- Conditions
- Cognitive/Functional Effects, Colorectal Cancer, Neurotoxicity
- Trial name
- NCT01279681
- Testing
- bevacizumab, capecitabine, fluorouracil
- Volunteers
- 32 people
- Sponsor
- Alliance for Clinical Trials in Oncology