Clinical trials: Older
Acute Coronary Syndrome/ Myocardial Infarction, Coronary Artery Disease
Enabling Patient-Reported Outcomes Through Innovative Care - ACS (EPIC-ACS)
This study evaluates the effectiveness of an innovative care approach that integrates face-to-face education, motivational counseling, and mobile health (mHealth) support delivered via the LINE application among Thai older adults…
- Trial name
- NCT07390006
- Testing
- Innovative Care Approach, Usual Post-Acute Coronary Syndrome Care
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Breast Carcinoma, Colorectal Adenocarcinoma
Vaccine Response With NT-I7
Background: People with cancer, and especially older people, have a weakened immune system (the defense system of the body). This is often caused by the treatments for cancer.
- Conditions
- Breast Carcinoma, Colorectal Adenocarcinoma, Bladder Carcinoma
- Trial name
- NCT04054752
- Testing
- Recombinant human IL-7-hyFc (NT-I7), Vaccine sequence 1, Vaccine sequence 2
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Low Back Pain
Physical Activity for Older Adults Chronic Low Back Pain
Chronic low back pain (cLBP) is one of the most common and disabling conditions among US military Veterans. Although physical activity can improve cLBP outcomes, the majority of Veterans with cLBP are inactive.
- Trial name
- PACe-LBP (NCT02327325)
- Testing
- Physical Activity, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Adherence, Patient
MI-CBT Adherence Program for Lifestyle Interventions in Older Adults
Objective 1: Assess feasibility and acceptability of all protocol components of a pilot trial testing a 6-week telehealth Mediterranean ketogenic nutrition adherence (KNA) program using motivational interviewing and cognitive…
- Conditions
- Mild Cognitive Impairment, Adherence, Patient, Ketosis
- Trial name
- MI-CBT KNAP (NCT04817176)
- Testing
- Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program, Ketogenic Nutrition Program
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Florida State University
Occupational Therapy, Nursing Caries
Spanish Adaptation and Validation of the Everyday Cognition Battery (ECB).
HYPOTHESIS: The Spanish version of the Everyday Cognition Battery Scale (ECB) is valid and reliable in the Spanish population. OBJECTIVES: Providing a validated scale in Spanish to evaluate daily cognition in older adults.
- Conditions
- Occupational Therapy, Nursing Caries, Aging Disorder, Cognitive Disorders
- Trial name
- NCT04169633
- Testing
- Cognitive Function Evaluation
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Psychological Distress, Chronic Disease
Interactive Nature-Based Virtual Reality to Reduce Anxiety, Low Mood, and Feelings of Helplessness in Hospitalized Older Adults With Chronic Illness (Zenctuary VR+)
Prolonged hospitalization can reduce opportunities for independent activity, choice, and control and may contribute to passivity, low mood, anxiety, and distress in some older adults.
- Conditions
- Psychological Distress, Chronic Disease, Learned Helplessness
- Trial name
- ZenctuaryVR+ (NCT07712549)
- Testing
- Interactive nature-based virtual reality intervention, Passive nature-based virtual reality exposure
- Where
- 3 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Moholy-Nagy University of Art and Design
Generalized Anxiety Disorder
Cognitive Behavioral Therapy (CBT) for Late Life Anxiety
The purpose of this research study is to assess the acceptability and feasibility of the implementation strategy and fidelity of cognitive-behavioral therapy (CBT) for older adults with Generalized Anxiety Disorder.
- Trial name
- NCT05380115
- Testing
- Cognitive Behavioral Therapy (CBT)
- Sponsor
- Wake Forest University Health Sciences
HIV Infection
EFV Pharmacokinetics & Pharmacogenomics in Older HIV-infected Patients
The primary purpose of this study is to investigate the steady-state pharmacokinetics of efavirenz in older HIV-infected patients as compared to historical controls; to investigate the relationship of drug exposure to…
- Trial name
- EFV (NCT01886404)
- Testing
- Efavirenz
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Fall Prevention in Healthy Aging
The Effects of an Exergame Training on Body and Brain of Older Adults
This study investigates the effects of an exergame training including strength, balance, and cognitive training components on motor functions, cognition and brain structure of older adults.
- Trial name
- Active@Home (NCT03676452)
- Testing
- Active@Home exergame training
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Eling DeBruin
Osteoarthritis
Acupressure for Knee Pain in Older Adults
The primary objective of this project is to determine whether self-administered acupressure is an effective and feasible self-management strategy for older adults with symptomatic KOA.
- Trial name
- AKP (NCT02003443)
- Testing
- Self-Administered Acupressure
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Michigan
Chronic Lymphocytic Leukemia
Frontline Treatment With Bendamustine in Combination With Rituximab in Adults Age 65 or Older With Chronic Lymphocytic Leukemia (CLL)
Many chemotherapy combinations may be used to treat patients with chronic lymphocytic leukemia (CLL). Although there are many options, a single, best option is not agreed upon by most cancer specialists.
- Trial name
- NCT00758693
- Testing
- Bendamustine, Rituximab
- Where
- United States
- Sponsor
- University of Kentucky
Hodgkin Lymphoma
BrEPEM-LH-22017 for Older Patients With Untreated Hodgkin Lymphoma (HL)
The purpose of the phase Ib of the study is to identify the maximum tolerated dose (MTD) of Brentuximab Vedotin (BV) in combination with EPEM and to assess the toxicity of the combination of BV with EPEM.
- Trial name
- NCT03576378
- Testing
- BrentuximabVedotin (BV)
- Where
- 15 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
Potentially Inappropriate Medications, Multimorbidity
Appropriate Prescribing for Older Adults With Multimorbidity (Pro-M)
This is a two-site feasibility study to test implementation of an intervention that aims to reduce inappropriate prescribing for older adults with multimorbidity in geriatric medicine specialist clinics at public hospitals in…
- Conditions
- Potentially Inappropriate Medications, Multimorbidity, Polypharmacy
- Trial name
- Pro-M (NCT05756478)
- Testing
- Medication review
- Where
- 2 sites in Singapore
- Volunteers
- 36 people
- Sponsor
- Geriatric Education and Research Institute
Loneliness, Social Isolation
Telephone Calls for Health for Homebound Older Adults
A randomized controlled trial of the effect of 4 weeks of regular check-in calls, up to 5 per week based on participant's choice and 2 survey collection calls and possible referral of other services, versus no daily check-in…
- Conditions
- Loneliness, Social Isolation, Depression
- Trial name
- NCT04595708
- Testing
- Phone Call
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Breast Cancer Survivorship
Patient Priorities for Survivorship Care in Older Breast Cancer Survivors
The objective of this study is to adapt the Patient Priorities Care (PPC) framework to breast cancer survivorship via a user-centered approach, through an iterative process in which patients and their physicians help to refine…
- Trial name
- NCT06478589
- Testing
- Adapted Patient Priorities Care (PPC) approach, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center, Houston
Learning; Lack of (Specific), Depression
Nano-Learning for Improving Compliance Among Older Adults With Sarcopenia
Empirical evidence suggests that the use of short videos is associated with decreased feelings of loneliness and social isolation, thereby reducing depression among older adults .
- Conditions
- Learning; Lack of (Specific), Depression, Older Adults, Sarcopenia
- Trial name
- NCT07185763
- Testing
- Nano-Learning interventional program
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Diphtheria, Tetanus
Canadian Manufactured Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine Compared With U.S. Manufactured Td
To compare the seroprotection rates and booster responses to Canadian-manufactured Tetanus and Diphtheria Toxoids Adsorbed vaccine to the seroprotection rates and booster responses to the US-manufactured Tetanus and Diphtheria…
- Trial name
- NCT00601835
- Testing
- Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine
- Where
- 2 sites in United States
- Volunteers
- 3,651 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Healhty, Aging
Video Game Intervention In Older Adults
The purpose of this clinical trial is to investigate the effects of a rehabilitative game-based intervention on self-efficacy, balance, and visual-motor integration in individuals aged 60 years and older.
- Conditions
- Healhty, Aging, Balance, Self Efficacy
- Trial name
- NCT07433608
- Testing
- Game-Based Virtual Reality Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Biruni University
Dizziness Chronic, Fall
Reducing Rate of Falls in Older People by Means of Vestibular Rehabilitation: Preliminary Study
The aim of this study is to evaluate the effectiveness of vestibular rehabilitation to improve the balance in older people and reduce the number of falls, comparing three arms with different vestibular rehabilitation strategies…
- Conditions
- Dizziness Chronic, Fall, Elderly
- Trial name
- ReFOVeRe (NCT03317353)
- Testing
- Vestibular rehabil.: CDP, Vestibular rehabil.: optokinetic stimuli, Vestibular rehabil.: home exercises
- Volunteers
- 139 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Kidney Disease, Kidney Failure
Hemodialysis in the Elderly (70yrs & Older)
This will be a prospective, single institution, parallel-group, single-blinded, randomized-controlled, two-arm, effectiveness study comparing autologous arteriovenous fistula versus hemodialysis access grafts in the elderly.
- Conditions
- Kidney Disease, Kidney Failure, Chronic Kidney Disease
- Trial name
- ELDERLY (NCT03065972)
- Testing
- Surgical fistula creation from patient's anatomy, Surgical Graft implant
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- E. Peden, MD