Clinical trials: Older Adults With Cancer
Acute Myeloid Leukemia (AML), Elderly Patients (60-75 Years)
VAH vs VA in Newly Diagnosed Elderly AML
This is a multicenter, open-label, randomized, controlled phase III clinical trial designed to evaluate the efficacy and safety of the combination of Venetoclax, Azacitidine, and Homoharringtonine (VAH) compared to Venetoclax and…
- Trial name
- NCT07469046
- Testing
- Venetoclax, Azacitidine, Homoharringtonine
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cancer Caregivers of Older Adults
Older Cancer Caregiver Needs Post Hospital Discharge
The goals of the study are to investigate the needs of older (age 60+) caregivers caring for adults with cancer at 1-week and 2 weeks following hospital discharge and to explore strategies that may assist caregivers in their home…
- Trial name
- NCT02099526
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Duke University
NSCLC
Chemotherapy of Elderly Patients With Non-Small-Cell Lung Cancer (NSCLC)
The last ASCO recommendations in 2003 for the treatment of a CBNPC of stage IIIB/IV of elderly people, are to manage a monochemotherapy.
- Trial name
- NCT00298415
- Testing
- Paclitaxel + Carboplatin, Monotherapy (gemcitabine or vinorelbine)
- Where
- 5 sites in France
- Volunteers
- 451 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Acute Myeloid Leukemia in Remission
Study of Azacytidine Combined With Lenalidomide As Maintenance Therapy Based on MRD Monitoring in AML
Great progress has been witnessed on the treatment of acute myeloid leukemia (AML) in recent years. However, elderly patients ineligible for receiving high dose chemotherapy and allo-HSCT, have high relapse rate and…
- Trial name
- NCT04490707
- Testing
- Azacitidine, Lenalidomide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ge Zheng
Advanced Care Planning (ACP), ELDERLY PEOPLE
Advance Care Planning Impact on the Consistency of Older Adults With Lung Cancer and Their Potential Surrogates Regarding Life-Sustaining Treatment Preferences
This randomized controlled trial examined whether an advance care planning (ACP) tabletop game ("Walking with Wishes") could improve the consistency of life-sustaining treatment preferences between older adults with lung cancer…
- Conditions
- Advanced Care Planning (ACP), ELDERLY PEOPLE, Lung Cancer (NSCLC)
- Trial name
- NCT06616909
- Testing
- ACP GAME, acp manual
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Lung Neoplasm, Thoracic Surgical Procedures
Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients
This multicenter prospective clinical study focuses on elderly patients with lung cancer. The investigators will build a standardized clinical registry database, develop perioperative risk stratification and surgical…
- Conditions
- Lung Neoplasm, Thoracic Surgical Procedures, Perioperative Care, Postoperative Rehabilitation
- Trial name
- NCT07632664
- Testing
- Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling, Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling, Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Tuberous Sclerosis Complex (TSC), Lymphangioleiomyomatosis (LAM)
Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)
This study will evaluate the safety and efficacy of RAD001 in treating patients with Angiomyolipoma associated with Tuberous Sclerosis Complex or Sporadic Lymphangioleiomyomatosis.
- Trial name
- EXIST-2 (NCT00790400)
- Testing
- Everolimus (RAD001)
- Where
- 25 sites in United States, Canada and 9 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
This phase II clinical trial studies how well dasatinib followed by stem cell transplant works in treating older patients with newly diagnosed acute lymphoblastic leukemia.
- Trial name
- NCT01256398
- Testing
- Alemtuzumab, Allogeneic Hematopoietic Stem Cell Transplantation, Autologous Hematopoietic Stem Cell Transplantation
- Where
- 101 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Cancer Institute (NCI)
Diffuse Large B-Cell Lymphoma
A Study of Brentuximab Vedotin, Rituximab, and Dose Attenuated CHP in Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL)
This is a study incorporating brentuximab vedotin and dose attenuated rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) into initial therapy for elderly patients with DLBCL.
- Trial name
- BV mini CHP (NCT02734771)
- Testing
- Brentuximab vedotin, Rituximab, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Patrick Reagan
Lymphoma
Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, and vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00726700
- Testing
- pegfilgrastim, rituximab, cyclophosphamide
- Volunteers
- 109 people
- Sponsor
- Universität des Saarlandes
Lung Neoplasms
Application of Generative Artificial Intelligence in Perioperative Personalized Rehabilitation for Older Adults With Lung Cancer
This study will evaluate whether a generative artificial intelligence (AI)-based rehabilitation support system can help older adults with lung cancer recover after lung surgery.
- Trial name
- NCT07915193
- Testing
- AI-guided personalized rehabilitation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Cancer Hospital & Institute
CLL (Chronic Lymphocytic Leukemia)
A Trial to Evaluate the Efficacy and Safety of a Fitness-adapted Thera-py Approach With Either Continuous Zanubrutinib Monotherapy or Time-limited Zanubrutinib + Sonrotoclax in Older and/or Frail Patients With Treatment-naïve CLL
The CLL-Frail2 trial will be a prospective, open-label, multicentre phase-II-trial to evaluate the efficacy and safety of a fitness-adapted therapy approach with either con-tinuous zanubrutinib (BGB-3111) monotherapy or…
- Trial name
- NCT07899398
- Testing
- Zanubrutinib, Sonrotoclax
- Volunteers
- 80 people
- Sponsor
- German CLL Study Group
Glioblastoma Multiforme
Chemoradiotherapy Versus Chemotherapy for Elderly and Frail GBM Patients
Currently, the optimal treatment regimen for elderly Glioblastoma (GBM) patients with poor performance status (PS) is unknown. Based on data for elderly GBM patients and the limited data for patients with poor PS…
- Trial name
- NCT04765514
- Testing
- Temozolomide monotherapy, Chemo-Radiotherapy with concurrent temozolomide.
- Where
- 2 sites in Canada
- Volunteers
- 107 people
- Sponsor
- AHS Cancer Control Alberta
Acute Myeloid Leukemia
Micro-transplantation in Elderly Patients With Acute Myeloid Leukemia
This study aims at evaluating the safety and the tolerance of the micro-transplantation in elderly patients with acute myeloid leukemia who are ineligible to conventional allogeneic transplantation.
- Trial name
- MTSA (NCT03439371)
- Testing
- HLA-mismatched micro-transplantation after induction chemotherapy
- Where
- 7 sites in France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Diffuse Large B Cell Lymphoma
Prospective Clinical Study of ZPR Regimen in Elderly Treatment-naive Diffuse Large B-cell Lymphoma
This is a prospective, single-arm, single-center clinical study. This clinical study aims to explore the efficacy and safety of the ZPR（Zanubrutinib, Polatuzumab vedotin and Rituximab）regimen in elderly patients with…
- Trial name
- NCT05940064
- Testing
- Zanubrutinib, Polatuzumab Vedotin, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peng Liu
Non Small-cell Lung Cancer
Trial Involving Subjects Over 70 Years of Age With Non Small-cell Lung Cancer of Stage IV and Comparing a "Classical" Strategy of Treatment Allocation, With an"Optimized" Strategy Allocating the Same Treatments
This is a phase III randomized multicenter study involving subjects over 70 years of age with non small-cell lung cancer of IV and a PS of 0, 1 or 2, who have not previously received chemotherapy.
- Trial name
- ESOGIA (NCT01257139)
- Testing
- Dual-agent therapy or docetaxel alone or best supportive care
- Where
- 45 sites in France
- Volunteers
- 490 people
- Sponsor
- Rennes University Hospital
Neurofibromatosis Type 1
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
This study is designed to define a dosing regimen and assess the pharmacokinetics(PK) and safety of the granule formulation; the study will also include descriptive analyses of exploratory efficacy endpoints.
- Trial name
- SPRINKLE (NCT05309668)
- Testing
- Selumetinib granule formulation, Selumetinib capsule formulation
- Where
- 16 sites in United States, Germany and 5 more
- Volunteers
- 36 people
- Sponsor
- AstraZeneca
Lung Cancer, Lung Carcinoma
Observational Study of the Efficacy and Safety of Anlotinib Combined With Penpulimab in Elderly Lung Cancer Patients
This prospective observational study will evaluate the efficacy and safety of anlotinib in combination with Penpulimab in elderly patients with lung cancer.
- Conditions
- Lung Cancer, Lung Carcinoma, Non Small Cell Lung Cancer, Non-small Cell Carcinoma
- Trial name
- AP (NCT05319886)
- Testing
- Anlotinib and Penpulimab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Benign Prostate Hyperplasia, Bladder Tumor
Effective Dose of Dexmedetomidine for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia With or Without Fentanyl by Age Groups: Randomized Comparative Study
Recently many studies reported that intraoperative dexmedetomidine administration undergoing spinal anesthesia give a satisfactory sedation in elderly patients and cause less respiratory depressions compared other sedatives(e.g.
- Trial name
- NCT01665586
- Testing
- dexmedetomidine
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Lymphoma
Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00039351
- Testing
- cyclophosphamide, prednisone, vincristine sulfate
- Where
- 17 sites in Belgium, Egypt and 5 more
- Volunteers
- 32 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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