Clinical trials: Older Adults With Cancer
Gastric Cancer, Chemotherapy Effect
Neoadjuvant Chemotherapy Plus Surgery Versus Surgery First For Elderly Gastric Cancer Patients
The main purpose of this study is to compare the feasibility and efficacy of neoadjuvant chemotherapy (modified SOX) for elderly patients with locally advanced gastric cancer.
- Conditions
- Gastric Cancer, Chemotherapy Effect, Elderly Patients, Surgery
- Trial name
- RJGC-Senile (NCT04677673)
- Testing
- Chemotherapy, Curative gastrectomy
- Volunteers
- 232 people
- Sponsor
- BIRENDRA KUMAR SAH
Unresectable Locally Advanced Pancreatic Cancer
Chemoradiotherapy in Elderly Patients with Locally Advanced Pancreatic Cancer (70+).
The goal of this observational study is to learn about the therapeutic effects of chemoradiotherapy for older adults (age 70-85) with locally advanced pancreatic cancer.
- Trial name
- NCT06844773
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Zhongshan Hospital
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Acute Myeloid Leukemia
Prospective Randomized Study Comparing One or Two High Dose Chemotherapy Regimen Followed by Autologous Stem Cell Transplantation
First randomization: After inclusion Use of Daunorubicin (arm D) or Idarubicin (arm I) as anthracyclin during all courses of chemotherapy (induction, consolidation courses before ASCT) Second randomization: After achieving 1st…
- Trial name
- AML2001 (NCT01015196)
- Testing
- Zavedos, Cerubidine
- Where
- France
- Volunteers
- 832 people
- Sponsor
- Nantes University Hospital
Diffuse Large B-Cell Lymphoma (DLBCL)
CRP Regimen in Treating Elderly Patients With Previously Untreated Double-Positive DLBCL
A Single-Arm, Open-Label, Multicenter Phase II Trial of CRP Regimen (Chidamide, Rituximab, Polatuzumab Vedotin) in Treating Elderly Patients with Previously Untreated Double-Positive Diffuse Large B-Cell Lymphoma
- Trial name
- NCT07397832
- Testing
- Chidamide, Rituximab, Polatuzumab Vedotin
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Acute Myeloid Leukemia
Modified-FLAI Induction and Consolidation Chemotherapy in Elderly Patient With Acute Myeloid Leukemia (AML)
A phase II clinical trial evaluating the efficacy and tolerability of induction and consolidation chemotherapy comprising Fludarabine, cytarabine and attenuated-dose Idarubicin (modified-FLAI) in the elderly patients with acute…
- Trial name
- m-FLAI (NCT01247493)
- Testing
- induction chemotherapy (fludarabine, cytarabine, idarubicin)
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Non Small Cell Lung Cancer, Advanced Lung Non-Small Cell Carcinoma
Study of Pembrolizumab With Single Agent Chemotherapy in Elderly Patients With Advanced NSCLC
This Phase II trial is to see how well single agent chemotherapy and pembrolizumab work elderly patients (≥ 75 years) with advanced non small cell lung cancer (NSCLC).
- Conditions
- Non Small Cell Lung Cancer, Advanced Lung Non-Small Cell Carcinoma, PD-L1 Gene Mutation
- Trial name
- HFHS 21-01 (NCT04754815)
- Testing
- Pembrolizumab, Pemetrexed, Paclitaxel
- Sponsor
- Shirish Gadgeel
Focus Groups
COACH-Cog Intervention Adaptation Focus Groups
To gather key stakeholder input for feedback on the adaption of the COACH GA intervention (i.e., develop COACH-Cog) to enhance triadic communication among oncologists, care partners and patients with ADRD.
- Trial name
- NCT05775991
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Rochester
Primary Central Nervous System Lymphoma
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System
Primary central nervous system lymphomas are rare aggressive malignancies, usually treated in two steps: an induction phase (where a combination of chemotherapy is given) followed by a consolidation phase (where patients usually…
- Trial name
- FIORELLA (NCT03495960)
- Testing
- Rituximab, Methotrexate, Procarbazine
- Where
- 34 sites in Denmark, Finland and 2 more
- Volunteers
- 72 people
- Sponsor
- International Extranodal Lymphoma Study Group (IELSG)
Myelogenous Leukemia, Acute, Myelodysplastic Syndromes
MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With Relapsed/Refractory Disease
In this study, MGCD0103, a new anticancer drug under investigation, is given three times per week to elderly patients with previously untreated acute myelogenous leukemia/high risk myelodysplastic syndrome or adults with…
- Trial name
- NCT00374296
- Testing
- MGCD0103
- Where
- 13 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- Mirati Therapeutics Inc.
Large B-cell Lymphoma, Diffuse Large B Cell Lymphoma
Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma
The goal of this clinical trial is to study the addition of Acalabrutinib to standard R-miniCHOP in older adults with DLBCL. The main question it aims to answer is whether progression free survival kann be prolonged with the…
- Trial name
- ARCHED (NCT05820841)
- Testing
- R-miniCHOP + Acalabrutinib, R-miniCHOP
- Where
- 17 sites in Germany
- Volunteers
- 330 people
- Sponsor
- Universität des Saarlandes
Diffuse Large B Cell Lymphoma
Pro-miniCHOP-like Regimen for Treatment-naive Elderly Patients
The proposed study is a prospective, single-center and open-ended study in patients over the age of 70 with treatment-naive diffuse large B-cell lymphoma (DLBCL).
- Trial name
- NCT05809180
- Testing
- Rituximab, Orelabrutinib, Pomalidomide
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Breast Cancer
ELDA: Elderly Breast Cancer - Docetaxel in Adjuvant Treatment
The purpose of this study is to compare disease free survival of elderly breast cancer patients treated with standard adjuvant chemotherapy (CMF) versus experimental adjuvant chemotherapy (weekly docetaxel).
- Trial name
- NCT00331097
- Testing
- docetaxel, cyclophosphamide, methotrexate
- Where
- 8 sites in Italy
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute, Naples
Advanced Solid Tumor
A Machine Learning-based Estimated Survival Model
Malignant tumors are the leading cause of death in elderly patients, and palliative care can improve the quality of life for elderly advanced cancer patients.
- Trial name
- NCT06432283
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhao Siyao
Diffuse Large B Cell Lymphoma
ZR2 Followed by Immunochemotherapy in Elderly Patients With Newly-diagnosed DLBCL
As the most common subtype of lymphoma, diffuse large B-cell lymphoma (DLBCL) is an aggressive but potentially curable malignancy.
- Trial name
- NCT05290090
- Testing
- Rituximab, Lenalidomide, Zanubrutinib and RCHOP
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Zhejiang Cancer Hospital
Mammographic Breast Density
Study of the Effects of Cyclodynon on Reducing the Cumulative Risk of Breast Cancer Development in a Female Aged 40-52
Increased mammographic density of mammary gland tissues and hyperprolactinaemia are regarded as one of the risk factors for the development of breast cancer in women aged 40 to 52 years, which necessitates closer monitoring of…
- Trial name
- BIO-CYCL (NCT04498013)
- Testing
- Cyclodynon, Lifestyl modification
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Dr. Struk Tetiana
Ovarian Cancer, Epithelial Ovarian Cancer
Prehabilitation for EOC, Fallopian Tube, Primary Peritoneal Carcinoma and Pancreatic Cancer w/ NACT
The purpose of this study is to see whether participants who are assigned to a multimodal prehabilitation intervention during chemotherapy are able to adhere with exercise and nutrition program to prepare for their cancer surgery.
- Conditions
- Ovarian Cancer, Epithelial Ovarian Cancer, Pancreatic Adenocarcinoma
- Trial name
- NCT06412510
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Case Comprehensive Cancer Center
Diffuse Large B Cell Lymphoma
Study Evaluating the Safety and Efficacy of iR2 in Untreated and Unfit Elderly Patients With DLBCL
This is a single-arm, open-label phase 2 study of iR2 in the treatment of unfit and elderly patients with untreated diffuse large B-cell lymphoma。
- Trial name
- NCT03949062
- Testing
- Ibrutinib, Lenalidomide, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Acute Myeloid Leukemia
Gemtuzumab Ozogamicin+Cytarabine vs Idarubicin+Cytarabine in Elderly Patients With AML.Mylofrance 4
Purpose : The main objective of this study is to assess the efficacy and tolerance of the addition of repeated doses of low doses (3mg/m2) of Gemtuzumab Ozogamicin (GO) in addition with standard doses of Ara-C in previously…
- Trial name
- ALFA1401 (NCT02473146)
- Testing
- Gemtuzumab ozogamicin (GO)
- Where
- 21 sites in France
- Volunteers
- 225 people
- Sponsor
- Versailles Hospital
Colorectal Cancer
Irinotecan With or Without Capecitabine as Second-Line Therapy in Treating Older Patients With Progressive, Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as irinotecan and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00303745
- Testing
- capecitabine, irinotecan hydrochloride
- Where
- 23 sites in France
- Volunteers
- 78 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
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