Clinical trials: Older Adults With Cancer
Suicidal Ideation, Mental Health
Gamified Virtual Reality Exercise for Suicidal Ideation in Older Adults
This is a two-arm, parallel-group randomized controlled trial designed to evaluate the effectiveness of a gamified virtual reality (VR)-based exercise program in reducing suicidal ideation among community-dwelling older adults…
- Conditions
- Suicidal Ideation, Mental Health, Depression, Geriatric Psychiatry
- Trial name
- VR-GAME-SI (NCT07862803)
- Testing
- Gamified VR-Based Exercise Program, Conventional Exercise Program
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Islamic Azad University, Sanandaj
Diffuse Large B-Cell Lymphoma
Mini-CHOP and Rituximab in Patients Aged Over 80 Years
The purpose of the study is to evaluate efficacy and safety of R-miniCHOP for elderly patients with diffuse large B-Cell lymphoma (DLBC) Lymphoma aged over 80 years by measuring the overall survival.
- Trial name
- NCT01087424
- Testing
- R mini CHOP
- Volunteers
- 150 people
- Sponsor
- Lymphoma Study Association
Geriatric Cancer Patients
A Chatbot-Powered G8 Screening Intervention to Facilitate Referrals to a Comprehensive Geriatric Assessment Among Older Adults With Cancer
In this prospective quality improvement study, we will develop and evaluate the feasibility and acceptability of an online patient self-reported G8 screening tool which will allow us to efficiently identify G8 positive older…
- Trial name
- NCT05535140
- Testing
- G8 Screening Tool
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Lymphoma, Mantle-Cell
Rituximab, Bendamustine and Cytarabine Followed by Venetoclax in High Risk Elderly Patients With MCL
Prospective, multicenter, phase II trial designed to evaluate whether the addition of Venetoclax after rituximab, bendamustine and cytarabine (R-BAC) to high risk patients with mantle cell lymphoma improves the results of the…
- Trial name
- NCT03567876
- Testing
- Venetoclax
- Where
- 35 sites in Italy
- Volunteers
- 141 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Cancer
Assessment of Frailty in Elderly Patients With Advanced Cancers
This study is looking at the feasibility of performing frailty assessments on elderly patients with advanced cancers
- Trial name
- FAC-C (NCT02482285)
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Colorectal Cancer
The Effect of IoC on Analgesia for Elderly Patients With Postoperative Effectiveness
The morbidity of colorectal cancer and the surgery number among elderly is growing. The investigators need to provide more advanced and specific monitoring technology for these patients.
- Trial name
- NCT02827682
- Testing
- Angel-6000D Multiparameter Anesthesia Monitor (IoC), BIS VISTA Monitor (BIS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Elderly Metastatic Breast Cancer Population
Elderly Metastatic Breast Cancer: Pertuzumab-Herceptin vs Pertuzumab-Herceptin-Metronomic Chemotherapy, Followed by T-DM1
Chemotherapy and HER2 targeted agents can improve survival significantly in metastatic breast cancer. Chemotherapy however is associated with significant side-effects and can impact on Quality of Life and functionality in older…
- Trial name
- NCT01597414
- Testing
- Pertuzumab + trastuzumab, Pertuzumab + trastuzumab + metronomic chemotherapy
- Where
- 30 sites in Belgium, France and 6 more
- Volunteers
- 80 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Rectal Neoplasms
Study of Postoperative Concurrent Chemo-radiation With Capecitabine in Elderly Rectal Cancer Patients
The purpose of this study is to seek the proper dose of capecitabine in post-operative concurrent chemotherapy for stage II/III elderly rectal cancer patients receiving radical surgery, and evaluate the toleration of this…
- Trial name
- NCT01268943
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chinese Academy of Medical Sciences
Colorectal Neoplasms
Geriatric Intervention in Frail Elderly Patients With Colorectal Cancer
This is a randomized, controlled trial on frail elderly patients (aged 65+) with colorectal cancer. The patients will be randomized into two groups. The control group will receive standard surgical treatment.
- Trial name
- NCT01321658
- Testing
- Geriatric intervention
- Where
- Norway
- Volunteers
- 122 people
- Sponsor
- Oslo University Hospital
Small Cell Lung Cancer ( SCLC )
A Single-arm, Exploratory Clinical Study Evaluating the Efficacy and Safety of Bevacizumab in Combination With Anlotinib and Etoposide as First-line Therapy for Elderly Patients With Small-cell Lung Cancer or Those Who Are Intolerant to Intensive Chemotherapy
A single-arm exploratory clinical study to observe and evaluate the first-line treatment of elderly and treatment-intolerant patients with small cell lung cancer using benmelstobart in combination with anlotinib and etoposide.
- Trial name
- SCLC (NCT07728955)
- Testing
- benmelstobart in combination with anlotinib and etoposide
- Volunteers
- 64 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lymphoma
Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00060385
- Testing
- CHOP regimen, EPOCH regimen, cyclophosphamide
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Patients Aged 50-75 and Requiring Colonoscopy
The French Gut-colo
Colorectal cancer (CRC) is the second most common type of cancer worldwide. The European Union recommends national CRC screening for people aged between 50 and 74.
- Trial name
- NCT06174233
- Where
- France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Non-Small Cell Lung Cancer
Efficacy and Safety of Sintilimab Combined with Platinum-containing Double-agent Chemotherapy in First-line Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer in Elderly Patients
To investigate the efficacy and safety of sindilizumab combined with platinum-containing dual chemotherapy in first-line treatment of elderly patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Trial name
- NCT06883136
- Testing
- Sintilimab+Cis-platinum/Carboplatin with Pemetrexed or Gemcitabine
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- Qianfoshan Hospital
Solid Tumor, Metastatic Solid Tumor
Validation of the G8 Screening Tool for Prognostic Assessment of Frailty and Early Mortality in Elderly Individuals With Cancer: Prospective Cohort Study in Brazil
This is a prospective observational cohort study including 250 individuals aged 70 years or older newly diagnosed with solid tumors.
- Conditions
- Solid Tumor, Metastatic Solid Tumor, Recurrent Solid Tumor
- Trial name
- CORALINE (NCT07773285)
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Latin American Cooperative Oncology Group
Colorectal Cancer
Inclusion of Elderly Patients With Colorectal Cancer in Clinical Trials
Background: Inadequate representation of elderly cancer patients in randomized clinical trials (RCTs) leading to a lack of external validity thereby an uncertainty regarding benefit-risk balance of cancer treatment in elderly…
- Trial name
- SAGE (NCT01754636)
- Testing
- No intervention
- Where
- France
- Volunteers
- 707 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukemia, Chronic Myeloid
Optimization of TKIs Treatment and Quality of Life in Ph+ CML Patients ≥60 Years in Deep Molecular Response
In this phase III clinical randomized study, "fixed" intermittent administration (one month ON/one month OFF) of TKIs (control arm), will be compared with "progressive" intermittent administration (one month ON/one month OFF for…
- Trial name
- NCT02326311
- Testing
- imatinib, nilotinib, dasatinib
- Where
- Italy
- Volunteers
- 229 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Anemia, Leukemia
Leridistim Compared With Filgrastim in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Colony-stimulating factors such as leridistim and filgrastim increase the number of immune cells found in…
- Conditions
- Anemia, Leukemia, Neutropenia, Thrombocytopenia
- Trial name
- NCT00004215
- Testing
- filgrastim, leridistim, cytarabine
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphoma, Chemotherapy-induced Neutropenia
Danish Elder Lymphoma Patient Hematopoietic Investigation
Every year approximately 300 Danish patients die from lymphoma. The median age at diagnosis is 70 years. Lymphoma can be efficiently treated with chemotherapy, and potentially cured.
- Conditions
- Lymphoma, Chemotherapy-induced Neutropenia, Chemotherapy-Related Leukemia, Chemotherapeutic Toxicity
- Trial name
- DELPHI (NCT05245487)
- Testing
- DNA repair gene mutation analysis
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Lymphocytic Leukemia
Ofatumumab as Front-Line Therapy in Treating Elderly Participants With Chronic Lymphocytic Leukemia
This phase II trial studies how well ofatumumab works as front-line therapy in treating elderly participants with chronic lymphocytic leukemia.
- Trial name
- NCT01444716
- Testing
- Ofatumumab
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Myelogenous Leukemia, Acute Myeloid Leukemia
A Study of Clofarabine for Older Patients With Newly Diagnosed Acute Myelogenous Leukemia (AML) (CLASSIC II)
Clolar (clofarabine injection) is approved by the Food and Drug Administration (FDA) for the treatment of pediatric patients 1 to 21 years old with relapsed acute lymphoblastic leukemia (ALL) who have had at least 2 prior…
- Trial name
- NCT00373529
- Testing
- clofarabine
- Where
- 20 sites in United States
- Volunteers
- 116 people
- Sponsor
- Genzyme, a Sanofi Company
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.