Clinical trials: Older Adults With Mild Neurocognitive Disorders
Spatial Navigation
Exploring to Remediate Behavioral Disturbances of Spatial Cognition
Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer's disease (AD), which occurs as a result of progressive neuropathology involving specific brain areas.
- Trial name
- BDSC-MCI (NCT05944601)
- Testing
- Virtual and computer-based cognitive remediation training
- Where
- Italy
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Memory Disorders, Alzheimer Disease
Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults
The current study will examine the impact of frequent social interaction through communication technologies during COVID-19 pandemic in the cognitive status of socially-isolated older adults with and without cognitive impairment.
- Conditions
- Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT04480112
- Testing
- Technology based social interactions, No research related technology based social interactions
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Boston University
Dementia, Cognitive Impairment, Mild
Repeated Transcranial Magnetic Stimulation in the Elderly With Cognitive Impairment
Introduction and Purpose: In recent years, non-pharmacological treatment methods for dementia patients have been gradually explored.
- Trial name
- NCT06192433
- Testing
- High-frequency repetitive transcranial magnetic stimulation (40Hz), Moderately high-frequency repetitive transcranial magnetic stimulation (10Hz)
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taipei Hospital, Ministry of Health and Welfare
Mild Cognitive Impairment (MCI), Virtual Reality
An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks
Driving ability in older adults is essential for independent mobility and social participation, yet declines under high cognitive load or distraction often lead to visual attention failures such as "look-but-fail-to-see,"…
- Conditions
- Mild Cognitive Impairment (MCI), Virtual Reality, Eye Movement Disorder, Multimodal Monitoring
- Trial name
- NCT07656389
- Where
- Taiwan
- Volunteers
- 192 people
- Sponsor
- National Cheng-Kung University Hospital
Mild Cognitive Impairment
Effects of tDCS on Cognition in MCI: A RCT
MCI is considered an intermediate stage between normal cognitive aging and dementia. As such, improving cognitive functions of people with MCI may delay dementia onset.
- Trial name
- NCT05584748
- Testing
- transcranial direct current stimulation
- Volunteers
- 48 people
- Sponsor
- Tung Wah College
Cognitive Impairment, Cognitive Impairment, Mild
Comparative Evaluation of Immediate vs Progressive Standing Dual Task Training in Elderly With Mild and Moderate Cognitive Impairment
older adults with mild and moderate cognitive impairment. compare immediate vs progressive standing dual-task training. assess balance, cognition, executive function, mobility, and quality of life.
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Moderate Cognitive Impairment
- Trial name
- NCT07764250
- Testing
- Immediate standing dual task training, progressive standing dual task training
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Shifa Tameer-e-Millat University
Geriatrics Rehabilitation
The Effect of Cognitive Telerehabilitation in Mild Cognitive Impairment
A quasi-experimental single-blind controlled trial with 36 elderlies with MCI. A three times a week computer-based cognitive telerehabilitation was given to intervention group for 12 weeks.
- Trial name
- NCT07042425
- Testing
- Computer based cognitive telerehabilitation
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Padjadjaran
Cognitive Impairment, Elderly
Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract product (CAP) in mildly demented elders on cholinesterase inhibitor therapy.
- Trial name
- NCT03937908
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Alzheimer's Disease
Utilization of Exergame Programs Among Elderly Residents in Rural Nursing Care Centers
Background: Cognitive impairment is prevalent among older adults and frequently misdiagnosed or diagnosed late, increasingly drawing attention as a significant health issue in aging populations.
- Trial name
- NCT06717971
- Testing
- Exergame-based multicomponent training program., Standard care
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Aoyu Li
Alcohol Use Disorder, Mild Cognitive Impairment
rTMS in Older Adults With MCI and AUD
Alcohol misuse is a risk factor for early onset cognitive impairment, contributing to 10% of early onset dementia, with risk corresponding to consumption.
- Conditions
- Alcohol Use Disorder, Mild Cognitive Impairment, Transcranial Magnetic Stimulation
- Trial name
- NCT05896332
- Testing
- Active, Open Label iTBS-rTMS
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Alzheimers Disease, Mild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor…
- Trial name
- NCT06484244
- Testing
- 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Amnestic Mild Cognitive Impairment
mSIM: Mobile Simultaneous Aerobic Exercise and Memory Training Intervention for Amnestic Mild Cognitive Impairment
The mSIM study involves developing and conducting feasibility testing of a web-based application that will deliver mobile-based simultaneous exercise and memory skills training program (mSIM) for amnesic Mild Cognitive Impairment…
- Trial name
- mSIM (NCT04185298)
- Testing
- mSIM intervention plus activity monitoring, Activity monitoring
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Jennifer Bramen
Parkinson Disease, Mild Cognitive Impairment
Adaptango Performance PRocess for Older Adults Community reHabilitation
This study is being done to answer the question: How do people with Parkinson's disease, people with Mild Cognitive Impairment, and younger people process difficult topics in conversation? It will also explore themes related to…
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
- Trial name
- APPROACH (NCT07824128)
- Testing
- Adaptango Performance Process (APP) program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Mild Cognitive Impairment
The Impact of Physical Exercise on Working Memory in Elderly People With Mild Cognitive Impairment
Age-related cognitive decline has evolved into a global public health concern, with deteriorated executive function serving as its predominant manifestation.
- Trial name
- NCT07644156
- Testing
- Resistance band exercise intervention, Brisk walking intervention, Eight-Section brocade exercise intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai University of Sport
Photo Neuro-Modulation Therapy, Mild Cognitive Impairment
Photo Neuro-Modulation Therapy to Adults
It is well-documented that mild cognitive impairment (MCI) is associated frontal lobe dysfunction and executive dysfunction. In addition, many studies reported high level of MCI symptoms among the elderly and the trend is…
- Trial name
- NCT04182529
- Testing
- Photoneuromodulation therapy
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Mild Neurocognitive Disorder
Feasibility of a Novel Exergame-Based Training Concept for Older Adults With Mild Neurocognitive Disorder
The primary objective of this pilot study is to evaluate the feasibility (i.e. recruitment, adherence, compliance, attrition), usability (i.e. system usability), and acceptance (i.e.
- Trial name
- NCT04996654
- Testing
- Exergame, Usual Care
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Eling DeBruin
Mild Cognitive Impairment
Effects of Multimodal Music Intervention on Mild Cognitive Impairment Elderly
The goal of this clinical trial is to learn about whether music therapy can ameliorate cognitive function, physical fitness and psychology in mild cognitive impairment and mild dementia population.
- Trial name
- NCT06324227
- Testing
- multimodal music therapy, no intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Falls, Frailty
Preventing Falls in Older Adults With Cognitive Frailty
The Problem: The proposed trial will address the problem of how to effectively prevent subsequent falls in community-dwelling cognitively frail older adults with a history of falls.
- Conditions
- Falls, Frailty, Mild Cognitive Impairment
- Trial name
- ACTIVE (NCT06854731)
- Testing
- Balance and Strength Training Exercises with Health Coaching, Education Session
- Where
- Canada
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Mild Cognitive Impairment
Effects of Cognitive Intervention for Older Adults With Memory Decline: A Pilot Study
The purpose of this study is to evaluate the effects of training in memory skills vs. use of external memory aids on everyday memory functioning in older people with mild cognitive impairment.
- Trial name
- NCT00609427
- Testing
- MEMO programme (Inst Universitaire de Geriatrie, Montreal), External memory aids training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre