Clinical trials: Olfaction
Stress, Anxiety
The Effects of Smell on Mood and Physical Responses
The purpose of this study is to examine the body's response to relaxing and stimulating fragrances commonly used in aromatherapy.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT00097253
- Testing
- Exposure to relaxant and stimulant odors
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Multiple Sclerosis
Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study
The sensation of smell is influenced by the somatosensory and chemesthetic sensati¬ons of the nose: for example, the cooling sensation of menthol or the prickle of carbon dioxide from carbonated drinks.
- Trial name
- NCT06020937
- Testing
- TDI, Trigeminal Test, Cognitive Evaluation by Montreal Cognitive Assessment
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Catania
Lichen Planus
Mucosal and Nasal Involvement and Their Correlation With Smell and Taste Functions in Lichen Planus Patients
This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes.
- Trial name
- LP-NOSE (NCT07570706)
- Testing
- Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
High-risk Prostate Cancer
Contribution of Canine Detection in the Diagnostic Strategy of High-risk Prostate Cancer (Prostate-K9-Detect)
The sense of smell allows both humans and dogs to carry out a chemo-sensory analysis of their environment. Volatile organic compounds enter the nasal cavities and bind to receptors in the nasal mucosa.
- Trial name
- NCT05558735
- Testing
- urine collection, canine detection
- Where
- France
- Volunteers
- 183 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
Singapore COVID-19 Chemosensory Tracking (SCCT) Study
The study aims to longitudinally track the onset, severity and recovery of changes in chemosensory acuity (smell and/or taste loss) among those suspected of COVID-19 infection.
- Trial name
- NCT04492904
- Testing
- Home-use Test and Follow-up Questionnaire
- Where
- Singapore
- Volunteers
- 102 people
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Stage 0 Nasopharyngeal Carcinoma, Stage 0 Paranasal Sinus Cancer
Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With Paranasal Sinus or Nasopharyngeal Cancer
This randomized phase I trial studies how well olfactory training works in improving sense of smell after radiation therapy in patients with paranasal sinus or nasopharyngeal cancer.
- Conditions
- Stage 0 Nasopharyngeal Carcinoma, Stage 0 Paranasal Sinus Cancer, Stage I Nasopharyngeal Carcinoma, Stage I Paranasal Sinus Cancer
- Trial name
- NCT03049358
- Testing
- Physiologic Testing, Quality-of-Life Assessment, Therapeutic Procedure
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
ESRD
Smell, Taste, Salivary Flow, and Oral Health in Patient Receiving Dialysis: A Before and After Study.
Studies show that the change of smell and taste, also dry mouth are the most common symptoms in end stage renal disease patients, the accumulation of uremic toxins would damage the intrinsinc antioxidant systems of the olfactory…
- Trial name
- NCT04401358
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Taiwan University Hospital
Alzheimer Disease, Mild Cognitive Impairment
Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly
Olfactory identification deficits occur in patients with Alzheimer's disease (AD), are associated with disease severity, predict conversion from mild cognitive impairment (MCI) to AD and are associated with healthy elderly…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Delirium, Dementia, Amnestic, Cognitive Disorders
- Trial name
- NCT01951118
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- New York State Psychiatric Institute
Olfactory Reference Syndrome
Internet Delivered CBT for Olfactory Reference Syndrome
The primary aim of the study is to test the feasibility and efficacy of, a manual based, Internet-delivered, cognitive behaviour therapy (CBT) for patients with Olfactory Reference Syndrome (ORS) who live in Sweden.
- Trial name
- NCT03846076
- Testing
- Cognitive behavioral therapy
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Volen Ivanov
Cancer Patients, Taste Disorders
New Food Solutions for Cancer Patients
The ONCOFOOD project aims to design and develop new innovative food solutions for cancer patients, taking into account not only their nutritional requirements but also their sensory changes, promoting eating pleasure and…
- Conditions
- Cancer Patients, Taste Disorders, Food Selection
- Trial name
- Oncofood (NCT04302792)
- Testing
- Texture-modified foods for cancer patients (Stage 2), Taste-optimised foods for cancer patients (Stage 3)
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Reading
Anosmia
Clinical Assessment of Insulin Fast Dissolving Film in Treatment of Post Infection Anosmia
The study aimed to investigate the efficacy of insulin in a new dosage form ( fast dissolving film) in treatment of anosmia in patients post infested with Covid-19. The study implication based in two methods evaluations 1.
- Trial name
- NCT04657809
- Testing
- Insulin film, Fast dissolving film
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soad Ali
Olfactory Neuroblastoma, Esthesioneuroblastoma
Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).
Background: Olfactory neuroblastoma (ONB) is a rare cancer of the nasal cavity. At diagnosis, it is usually locally advanced. It tends to spread to the neck. Sometimes it spreads to the lungs and bones.
- Conditions
- Olfactory Neuroblastoma, Esthesioneuroblastoma, Neoplasm of the Nasal Cavity
- Trial name
- NCT05012098
- Testing
- Bintrafusp alfa/M7824, Ibuprofen, PET scan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
COVID - 19
Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 COVID-19 (Covid-Smell)
The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.
- Trial name
- COVID-SMELL (NCT07190911)
- Testing
- Olfactory rehabilitation consists of smelling a series of spices every day for 2 months
- Where
- Guadeloupe
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Mild Birth Asphyxia, Moderate Birth Asphyxia
Olfactory Testing in Perinatal Asphyxia: Enhancing Risk Assessment
Neonatal asphyxia remains a leading cause of neurodevelopmental disabilities despite advancements in perinatal care. Hypoxic-ischemic encephalopathy (HIE), a severe outcome of asphyxia, impacts 1-3 infants per 1,000 live births…
- Trial name
- MEMOBRAIN (NCT06744244)
- Testing
- Olfactory Testing, Heart rate (HR), Heart Rate Variability (HRV), Respiratory Rate (RR), peripheral oxygen saturation (SpO2), Video-EEG
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Parma
Mild Cognitive Impairment
Olfactory Training in Mild Cognitive Impairment
Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline.
- Trial name
- OTMCI (NCT06825403)
- Testing
- Olfactory Memory Training, Visual Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Motter
Anosmia, Covid19
Visual-OLfactory Training in Participants With COVID-19 Resultant Loss of Smell
Olfactory dysfunction is a defining symptom of COVID-19 infection. As the number of total, confirmed COVID-19 cases approached 19 million in the United States, it is estimated that there will be 250,000 to 500,000 new cases of…
- Conditions
- Anosmia, Covid19, Ageusia, Hyposmia
- Trial name
- VOLT (NCT04710394)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Washington University School of Medicine
Parkinson´s Disease
Olfaction in Patients With Parkinson's Disease Following Treatment With Rasagiline
There is convincing evidence from numerous studies using both psychophysical and electrophysiological approaches that olfaction is markedly reduced in Parkinson´s disease (PD).
- Trial name
- NCT00902941
- Testing
- Azilect 1mg
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Technische Universität Dresden
Parkinson's Disease
Decrease in Sense of Smell and Associated Cognitive Decline in Parkinson's Disease
The overarching goal of this prospective cohort study is to test the hypotheses that greater severity of hyposmia is associated with increased risk of cognitive decline in PD and that worsening hyposmia parallels progressive…
- Trial name
- OLF (NCT01572142)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
COVID-19, Hyposmia
Olfactory Training in COVID-19 Associated Loss of Smell
Olfactory dysfunction (OD) like hyposmia or anosmia has been realized as a common symptom or even cardinal sign of the disease and can be persisting after recovering.
- Trial name
- NCT05421221
- Testing
- Sniffin' sticks Duftquartett
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Medical University Innsbruck
Anosmia, Smell Loss
Intranasal Insulin for COVID-19-related Smell Loss
The aim of this study was to quantify the improvement in olfaction of 27 post-COVID-19 patients, after three intreventions of intranasal insulin during a four week period, with the help of the Threshold, Discrimination and…
- Conditions
- Anosmia, Smell Loss, Paraosmia, Hyposmia
- Trial name
- NCT05461365
- Testing
- Insulin
- Where
- Mexico
- Volunteers
- 27 people
- Sponsor
- Universidad Panamericana