Clinical trials: Olfaction
Bladder Cancer, Breast Cancer
Docetaxel in Treating Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to compare the effectiveness of docetaxel in treating Caucasian and African American…
- Conditions
- Bladder Cancer, Breast Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00003565
- Testing
- docetaxel
- Where
- 74 sites in United States, Canada and 1 more
- Volunteers
- 109 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Head and Neck Cancer, Pain
Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer
RATIONALE: Acupuncture may help relieve pain and dysfunction caused by cancer surgery. It is not yet known whether acupuncture is more effective than standard therapy in treating pain and dysfunction in patients who have…
- Trial name
- NCT00090337
- Testing
- acupuncture therapy, standard follow-up care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cardiovascular Diseases, Cardiovascular Risk Factor
Chinese Multi-provincial Cohort Study-Beijing Project
The Chinese Multi-provincial Cohort Study (CMCS)-Beijing project is a sub-study in CMCS participants from Beijing, which intended to investigate the progression and determinants of atherosclerosis and aging related health…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Aging Problems, Smell Disorder
- Trial name
- CMCS-Beijing (NCT04253054)
- Testing
- Cardiovascular risk factors, Aging related health problems
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Fibromyalgia
Evaluation of Smell and Taste in Fibromyalgia
Patients diagnosed with fibromyalgia syndrome according to 2016 ACR criteria and 18-70 years old healthy subjects will be included in the study. Their smell and taste will be assessed with sniffin sticks and taste strips.
- Trial name
- NCT03823937
- Testing
- Sniffin' Sticks test and Taste strips
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Bladder Cancer, Breast Cancer
Chemotherapy in Treating Patients With Refractory Advanced Solid Tumors or Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of…
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT00004065
- Testing
- tanespimycin
- Where
- 2 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction
PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study.
This is a prospective, single-center, single-arm, non-comparative descriptive pilot study evaluating autologous platelet-rich plasma (PRP) injections in adults with persistent (>6 months) non-tumoural olfactory dysfunction…
- Conditions
- Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction, Age-related Degenerative Olfactory Dysfunction
- Trial name
- PANDORA (NCT07473830)
- Testing
- Autologous Platelet-Rich Plasma (PRP) Injection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Food Intake
Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell
The purpose of this study is to determine whether the blood pressure medication, diltiazem, will temporarily decrease the sense of smell when given in a nasal spray which will then reduce food intake.
- Trial name
- NCT01021176
- Testing
- Diltiazem
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Changes in Olfactory Behavior Across Different Contexts Associated With Different Amygdala Subregions
Characterization of Human Olfactory Amygdala Subregions exp2
We aim to better understand the functions of the subregions of the human amygdala that receive direct projections from the olfactory bulb
- Trial name
- NCT07074574
- Testing
- Present odors to participants while recording brain activity using fMRI
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Oncological Patients, Tyrosine Kinase Inhibitor
The TASTY-training Study
A multicentre non-blinded randomised intervention trial with a parallel cluster design. The multicentre study will be performed at 12 hospitals in the Netherlands.
- Trial name
- TASTY-training (NCT07258589)
- Testing
- Taste and smell training
- Where
- 11 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- University Medical Center Groningen
Paranasal Sinus Cancer, Nasal Cavity Tumor
A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages
This study is being done to test a new treatment plan for large tumors in the sinus or nasal cavity that will include endoscopic surgery plus chemotherapy and proton-beam radiation therapy.
- Conditions
- Paranasal Sinus Cancer, Nasal Cavity Tumor, Nasal Cavity Adenocarcinoma
- Trial name
- NCT03274414
- Testing
- Cisplatin, Adjuvant Proton Radiotherapy, Endoscopic Resection
- Where
- 5 sites in United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Olfactory Disorder, Taste Disorders
Prospective Registery of Smell/Taste Clinic Ear/Nose/Throat
Smell/taste disorders are common conditions with a significant impact on quality of life. In September 2021, a specific consultation for patients with smell and taste disorders was initiated at the ENT-HNS (ear, nose, and throat…
- Conditions
- Olfactory Disorder, Taste Disorders, Smell Dysfunction, Smell Disorder
- Trial name
- ProspeRo'Scent (NCT06456008)
- Testing
- Standard of care
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colon Cancer Screening, Colon Polyps
Reduction of Conscious Sedation Requirements by Olfactory Stimulation
Colonoscopy for investigation of lower gastrointestinal complaints or for colon cancer screening is one of the more frequent procedures performed by the Divisions of General Surgery and Gastroenterology.
- Trial name
- NCT00417001
- Testing
- Aroma therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Olfactory Disorder
Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIAL
About One to 2 percent of the North American population below the age of 65 years experience olfactory loss to a significant degree.
- Trial name
- NCT03574701
- Testing
- Vitamin A
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- St. Paul's Hospital, Canada
Multiple Sclerosis
Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study
The sensation of smell is influenced by the somatosensory and chemesthetic sensati¬ons of the nose: for example, the cooling sensation of menthol or the prickle of carbon dioxide from carbonated drinks.
- Trial name
- NCT06020937
- Testing
- TDI, Trigeminal Test, Cognitive Evaluation by Montreal Cognitive Assessment
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Catania
Anosmia, Covid19
Visual-OLfactory Training in Participants With COVID-19 Resultant Loss of Smell
Olfactory dysfunction is a defining symptom of COVID-19 infection. As the number of total, confirmed COVID-19 cases approached 19 million in the United States, it is estimated that there will be 250,000 to 500,000 new cases of…
- Conditions
- Anosmia, Covid19, Ageusia, Hyposmia
- Trial name
- VOLT (NCT04710394)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Washington University School of Medicine
SARS-CoV Infection, Covid19
Can the Electronic Nose Smell COVID-19 Antibodies?
Corona Virus Disease (COVID-19), spread worldwide and has become an emergency of major international concern. In March 2020, the WHO declared the COVID-19 outbreak a global pandemic.
- Trial name
- NCT04475575
- Testing
- Aeonose
- Where
- Netherlands
- Volunteers
- 222 people
- Sponsor
- Maastricht University Medical Center
Ovarian Cancer
Early Detection of Ovarian Cancer: GC/FT-ICR Mass Spectrometry and Canine Olfaction
RATIONALE: Studying samples of exhaled breath from patients with ovarian epithelial cancer, polycystic ovarian syndrome, or endometriosis and from healthy participants in the laboratory may help doctors identify and learn more…
- Trial name
- NCT00757952
- Testing
- Fourier transform ion cyclotron resonance mass spectrometry, chromatography, diagnostic laboratory biomarker analysis
- Where
- 4 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Pine Street Foundation
Olfaction Disorders, COVID-19 Testing
Rapid Screening for Olfactory Disorders in Covid-19 Infection
Loss of smell is very frequently found in Europe during Covid-19 attack. This symptom was not initially expected as part of the classic symptomatology.
- Trial name
- OLFASCAN (NCT04696601)
- Testing
- Olfactory test
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Chronic Rhinosinusitis With Nasal Polyps
Mechanisms of Smell Improvement With Dupilumab.
This study seeks to explore the mechanism through which dupilumab improves olfactory cleft inflammation in patients with chronic sinusitis with nasal polyps (CRSwNP).
- Trial name
- NCT05964465
- Testing
- Dupilumab
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina