Clinical trials: One-Lung Ventilation, open to volunteers
Lung Cancer (Diagnosis)
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.
- Trial name
- NCT07393490
- Testing
- Apnoeic Oxygenation, Standard Ventilation
- Where
- Croatia
- Volunteers
- 56 people
- Sponsor
- Osijek University Hospital
One-lung Ventilation (OLV), Video-assisted Thoracis Surgery (VATS)
Comparison of Different Ventilation Modes in Video-Assisted Thoracoscopic Lung Resection
One-lung ventilation (OLV) is required for video-assisted thoracoscopic surgery (VATS) lung resection, but it exposes the dependent lung to atelectasis, high driving pressures, and oxidative stress, and is associated with…
- Trial name
- OLV-VENT (NCT07866170)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
One-lung Ventilation (OLV)
Correlation of Oxygenation and Saturation Indices in One-Lung Ventilation
One-lung ventilation is commonly used during thoracic surgery but is frequently associated with impaired oxygenation and altered respiratory mechanics.
- Trial name
- OLV-INDICES (NCT07381517)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Lung Cancer, OLV
Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?
Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch.
- Conditions
- Lung Cancer, OLV, Hypoxemia During Surgery
- Trial name
- OLV (NCT07494006)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
High Altitude, Healthy Adult
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently >2600m.
- Conditions
- High Altitude, Healthy Adult, Echocardiography, Pulmonary Resistance
- Trial name
- NCT07804485
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Video-Assisted Thoracoscopic Surgery, One-Lung Ventilation
Trending Ability of End-Tidal Capnography to Reflect Arterial Carbon Dioxide Changes in One-Lung Ventilation
In this study, we want to find out if measuring carbon dioxide from a patient's breath (end-tidal CO₂ or ETCO₂) can reliably reflect changes in blood carbon dioxide levels (arterial CO₂ or PaCO₂) during lung surgery.
- Conditions
- Video-Assisted Thoracoscopic Surgery, One-Lung Ventilation, Capnography, Blood Gas Analysis
- Trial name
- NCT06835894
- Volunteers
- 115 people
- Sponsor
- Koç University
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Validation of 1 Minute Sit-to Stand Test for Assessment of Breathlessness at Exertion in Individuals With Chronic Lung Disease
Breathlessness is a common symptom in people with chronic lung and heart diseases. It can affect daily activities, quality of life, and overall health.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Interstitial Lung Disease (ILD)
- Trial name
- V1BE (NCT07836764)
- Testing
- 1MSTS
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Jacob Sandberg
Thoracic Anesthesia, Thoracotomy Surgery
Mechanical Power in One-lung Ventilation
Thoracic surgery usually necessitates one-lung ventilation (OLV) to provide surgical access while maintaining adequate gas exchange.
- Trial name
- POWEROL (NCT07353788)
- Volunteers
- 300 people
- Sponsor
- Ankara University
One-lung Ventilation (OLV), Thoracic Surgery
Comparison of FCV and VCV in One-Lung Ventilation
One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters…
- Conditions
- One-lung Ventilation (OLV), Thoracic Surgery, Respiratory Mechanics
- Trial name
- FCVOLVent (NCT07392086)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
One Lung Ventilation, Intubation Complication
Videolaryngoscopy vs Direct Laryngoscopy for Double Lumen Tube Lumen Tube Placement - A Multicentre Randomized-controlled Trial (VOLCANO Study)
The general aim of the study is to observe whether the use of the Mc Grath™ videolaryngoscope instead of direct laryngoscopy can represent, as in the case of the single-lumen tube, an added value in the placement of the…
- Trial name
- VOLCANO (NCT06466759)
- Testing
- Mc Grath Videolaryngoscope
- Volunteers
- 750 people
- Sponsor
- Luca Brazzi
Lung Cancer (Diagnosis), Pulmonary Complications in Surgical Patients
Effect of Mechanical Power-based Lung-protective Ventilation During One-lung Ventilation
The goal of this clinical trial is to determine whether a mechanical power-based lung-protective ventilation strategy during one-lung ventilation reduces the incidence of postoperative pulmonary complications in adult patients…
- Trial name
- NCT07772804
- Testing
- Mechanical power-based lung protective ventilation, Conventional lung protective ventilation
- Where
- South Korea
- Volunteers
- 164 people
- Sponsor
- Samsung Medical Center
Lung Cancer, Pulmonary Nodule
Video Double-Lumen Tube for Secondary Pulmonary Resection
During thoracic surgery, double-lumen endotracheal intubation with one-lung ventilation is routinely performed to optimize surgical exposure, facilitate operative manipulation, and prevent iatrogenic lung injury.
- Trial name
- NCT07467005
- Testing
- Video Double-Lumen Tube Group, Conventional Double-Lumen Tube Group
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Zhejiang University
Atelectasis, Postoperative Pulmonary Complications
Effect of Inspired Oxygen Concentration on Postoperative Atelectasis After VATS Lobectomy
This study aims to investigate whether using 50% FiO₂ during one-lung ventilation, compared with 100% FiO₂, reduces postoperative atelectasis in the non-dependent (healthy) lung of patients undergoing VATS pulmonary lobectomy…
- Trial name
- NCT07721558
- Testing
- Low inspired oxygen concentration (FiO₂=50%) during one-lung ventilation, High inspired oxygen concentration (FiO₂=100%) during one-lung ventilaion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Esketamine, One-lung Ventilation
Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery
A total of 126 patients undergoing elective thoracoscopic surgery under general anesthesia were randomly divided into three groups: normal saline group (Group C), dexmedetomidine group (Group D), and esketamine group (Group…
- Conditions
- Esketamine, One-lung Ventilation, Oxygenation Indices
- Trial name
- OLV;Esk (NCT06822088)
- Testing
- Esketamine, Dexmedetomidine, Normal Saline
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Jinqiao Qian
Pulmonary Disease (COPD), Chronic Obstructive, Lung Resection Surgery
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP…
- Trial name
- NCT07638176
- Testing
- PEEP0, PEEP5, PEEPi
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Samsung Medical Center
Pulmonary Complications, Hypoxemia During Surgery
Association of Different Tidal Volumes and Postoperative Pulmonary Complications
The incidence of lung cancer in China is increasing year by year. Currently, the treatment primarily based on video-assisted thoracoscopic surgery (VATS) is still considered the optimal approach for early-stage non-small cell…
- Conditions
- Pulmonary Complications, Hypoxemia During Surgery, Thoracic Surgery, Video Assisted, One Lung Ventillation (OLV)
- Trial name
- NCT07372378
- Volunteers
- 650 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804693
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in patients with pulmonary arterial hypertension PAH, who live permanently >2600m.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Polygraphy, Sleep
- Trial name
- NCT07801963
- Testing
- Descent to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Airway Extubation, Extubation Failure
One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Extubation Failure, Weaning Mechanical Ventilation
- Trial name
- GS-Wean Tpiece (NCT07324382)
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Lung Surgery
Impact of Reventilation After One-Lung Ventilation in Thoracic Surgery (OLVREEXP)
Lung cancer is a common disease, and more than 8,000 patients in France undergo lobectomy or pulmonary segmentectomy each year. This surgery remains associated with significant postoperative pulmonary complications, whose…
- Trial name
- OLVREEXP (NCT07247500)
- Testing
- Bipulmonary Reventilation using the accessory circuit, Bipulmonary Reventilation under controlled ventilation
- Where
- 5 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Rouen