Clinical trials: Onychomycosis of Toenails
Onychomycosis of Toenail
Light Therapy for Onychomycosis Study
This is a pilot prospective study designed to capture information about the safety and effectiveness of the ToeFX Therapy Light.
- Trial name
- NCT05139888
- Testing
- Single wavelength light (red) only, Dual wavelength light (red/blue)
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ToeFX Inc.
Onychomycosis
A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail
Approximately 40 qualified subjects with mild-to-moderate great toenail fungus infection will be treated for 48 weeks with lacquer application to at least one affected great toenail.
- Trial name
- NCT00385502
- Testing
- EcoNail™ (econazole 5%/SEPA® 18% nail lacquer)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Abeona Therapeutics, Inc
Tinea Unguium, Onychomycosis
Systemic Uptake of Diclofenac Sodium in Combination With Miconazole as Antifungal Nail Gel When Applied Daily With Monitoring of Hepatic and Renal Enzymes, and Serum Levels of Diclofenac 12 Hours After Application, and at 3 and 6 Months Study
Study evaluates these take of diclofenac sodium when used in conjunction with miconazole and urea as a topical antifungal nail gel treatment for onychomycosis.
- Trial name
- NCT04341402
- Testing
- Antifungal Nail Gel Study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- William N Handelman
Onychomycosis
Study Comparing SUBA™-Itraconazole With SPORANOX® (Itraconazole) in the Treatment of Onychomycosis
The objective of this study is to compare the relative efficacy and safety of SUBA™-Itraconazole Capsules (HalcyGen Ltd) to an already marketed oral formulation of itraconazole SPORANOX® (itraconazole) capsules (Janssen Pharma)…
- Trial name
- NCT00791219
- Testing
- SUBA-itraconazole, Itraconazole
- Where
- 8 sites in United States
- Volunteers
- 175 people
- Sponsor
- Halcygen Pharmaceuticals Limited
Distal Subungual Onychomycosis
A Study to Evaluate TMI-358 in the Treatment of Distal Subungual Onychomycosis
The purpose of this study is to determine if a local treatment is effective for the treatment of toenail fungus (distal subungual onychomycosis).
- Trial name
- NCT01093118
- Testing
- TMI-358, MMI-467
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Talima Therapeutics, Inc.
Onychomycosis
Using Light Therapy to Treat Toe Nail Fungus
To see if four sessions of light therapy successfully treats nail fungus.
- Trial name
- NCT00771732
- Testing
- light therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nomir Medical Technologies
Onychomycosis/Onycholysis and Tinea Pedis
Safety and Pharmacokinetics of Terbinafine Hydrogen Chloride (HCl) Nail Lacquer in Patients With Onychomycosis
In this study, the safety and pharmacokinetics of 10 % terbinafine hydrogen chloride (HCl) nail lacquer wre investigated by comparison with vehicle control and 1% terbinafine cream
- Trial name
- NCT00691184
- Testing
- Terbinafine Hydrochloride, Terbinafine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.)
Onychomycosis of Toenail
A Phase 2 Study to Assess the Effectiveness of Topical Terbinafine in Participants With Mild to Moderate Onychomycosis of the Toenails
Onychomycosis is a fungal infection of the toenail caused by a range of organisms, including dermophytes, non-dermophyte molds, and yeasts.
- Trial name
- NCT07382427
- Testing
- 2.4% Topical Terbinafine, 10% Topical Efinaconazole, Vehicle Control
- Volunteers
- 200 people
- Sponsor
- Onyx Axiom
Onychomycosis
Study of Erchonia Low Level Laser Light Therapy to Treat Toenail Fungus
The purpose of this study is to determine whether low level laser light therapy is effective in the treatment of toenail onychomycosis.
- Trial name
- NCT02242019
- Testing
- Erchonia LUNULA
- Where
- Ireland
- Volunteers
- 109 people
- Sponsor
- Erchonia Corporation
Onychomycosis
Efficacy Study of LIQUICURE™ to Treat Toe Nail Fungus
There is a major clinical need for an inexpensive topically-applied product that can inhibit the growth of the dermatophytes that cause nail fungus.
- Trial name
- CT001 (NCT00960089)
- Testing
- LIQUICURE
- Where
- 4 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chesson Laboratory Associates, Inc
Onychomycosis of Toenail
Efficacy and Safety of a Medical Device for the Treatment of Toenail Onychomycosis
This study evaluates the effect of the medical device "Excilor® Forte" in the treatment of toenail onychomycosis. Half of the participants will receive the tested product and the other half will receive a comparator (Amorolfin…
- Trial name
- NCT03382717
- Testing
- Excilor Forte, Loceryl 5%
- Where
- 2 sites in Tunisia
- Volunteers
- 102 people
- Sponsor
- Oystershell NV
Dermatologic Disease, Onychomycosis of Toenail
Photodynamic Therapy and Topical Antifungal for Onychomycosis in Patients With Diabetes.
There are different therapeutic alternatives for onychomycosis. Systemic therapy is widely used due to its easy accessibility, low cost and high efficacy, but may be associated with systemic adverse events and drug-drug…
- Conditions
- Dermatologic Disease, Onychomycosis of Toenail, Diabetic Foot, Diabetes Mellitus
- Trial name
- NCT06485050
- Testing
- Photodynamic therapy
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad Complutense de Madrid
Onychomycosis
A Study to Evaluate Efficacy and Safety of Four Posaconazole Regimens With Placebo and Terbinafine in the Treatment of Toenail Onychomycosis (Study P05082AM2)(COMPLETED)
The purpose of this study is to evaluate the efficacy, safety, and tolerability of oral administration of four dosing regimens of posaconazole relative to placebo and terbinafine, in the treatment of toenail onychomycosis.
- Trial name
- NCT00491764
- Testing
- SCH 56592, Terbinafine
- Volunteers
- 218 people
- Sponsor
- Merck Sharp & Dohme LLC
Onychomycosis
Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis
The purpose of this study is to determine if the iontophoretic application of terbinafine gel is safe and effective for teh treatment of distal subungual onychomycosis
- Trial name
- NCT01080079
- Testing
- Terbinafine Hydrochloride, Purified Water
- Where
- 9 sites in United States, Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Nitric BioTherapeutics, Inc
Onychomycosis of Toenail, Onychomycosis
Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail)
A study to determine if a three-treatment protocol with the RenewalNail™ plasma treatment system over a week will result in mycological cure and/or clear nail growth on the treated hallux toe.
- Trial name
- NCT03216200
- Testing
- plasma treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DeviceFarm, Inc.
Onychomycosis
Iontophoretic Application of Terbinafine Gel to the Large Toe Nail
Terbinafine is recognized as one of the most effective drugs for the treatment of toe nail fungus (onychomycosis). This trial will be the first test of a new device to improve the delivery of terbinafine directly to the toe nail.
- Trial name
- NCT00768768
- Testing
- Electrokinetic Transungual System (ETS) - Terbinafine Gel, ETS-Terbinafine Gel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Transport Pharmaceuticals
Onychomycosis of Toenails
Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail
The purpose of this study is to determine whether AN2690 topical solution is a safe and effective treatment for onychomycosis of the toenail.
- Trial name
- NCT01302119
- Testing
- AN2690 Topical Solution, 5%, Solution Vehicle
- Where
- 32 sites in United States, Canada
- Volunteers
- 604 people
- Sponsor
- Pfizer
Onychomycosis
Safety and Efficacy of NVXT Solution in Mild-to-Moderate Fungal Infection of the Toe Nail
This study will examine the safety, tolerability and efficacy of NVXT in a new formulation in patients with mild-to-moderate fungal infection of the toe nail.
- Trial name
- NCT02343627
- Testing
- NVXT Solution, Vehicle of test product
- Volunteers
- 47 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Onychomycosis
Open-Label Pharmacokinetics (PK)/Safety Study of Luliconazole Solution, 10% in Distal Subungual Onychomycosis
To determine the safety, tolerability, systemic exposure and pharmacokinetics of luliconazole after repeat daily topical application of Luliconazole Solution, 10% in a maximal use setting in adults with distal subungual…
- Trial name
- NCT01044381
- Testing
- Luliconazole Solution, 10%
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Topica Pharmaceuticals
Onychomycosis
TDT 067 Onychomycosis Study
The aim of this study is to establish the efficacy, clinical benefits, and safety of treatment with TDT 067 for clinically diagnosed distal subungual onychomycosis of the toenails caused by dermatophytes confirmed by positive…
- Trial name
- NCT01145807
- Testing
- TDT067, Transfersome
- Where
- United States
- Volunteers
- 738 people
- Sponsor
- Celtic Pharma Development Services