Clinical trials: Oocyte
Fertilization
Mechanical Stimulation Improve the Fertilization in ICSI Cycle
Most fertilization failures after ICSI are caused by failure of oocyte activation defects. But, to date, there is no effective method to overcome this obstacle.
- Trial name
- NCT03810001
- Testing
- Mechanical Stimulation
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Infertility
Morphometrics and Morphokinetics of Thawed Oocytes and Embryos
The aim of this observational study is to describe for the first time a complete set of morphometric and morphokinetic parameters of frozen-thawed human embryos in order to select the embryo with the highest implantation…
- Trial name
- NCT02639715
- Volunteers
- 1,272 people, healthy volunteers welcome
- Sponsor
- Sophie Debrock
Ovarian Reserve
CD133 Transplantation to Generate Oocytes in Poor Ovarian Reserve
Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developped nevertheless none of them optimal: the number of…
- Trial name
- NCT01966536
- Testing
- CD133+ cells transplantation into ovarian artery of one ovary
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Dehydroepiandrosterone, DHEAS
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is one the challenge in the field of artificial reproductive technology (ART) while there is still no effective resolution of this disorder.
- Conditions
- Dehydroepiandrosterone, DHEAS, Gene Expression of Cumulus Cells., Ovarian Hyper-stimulation Protocol.
- Trial name
- NCT02150330
- Testing
- Dehydroepiandrosterone (DHEAS)
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Increased Oocyte Death, in Vitro Maturation
GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)
Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM).
- Conditions
- Increased Oocyte Death, in Vitro Maturation, GREM1 Gene Mutation, Cumulus Cell
- Trial name
- NCT06315777
- Testing
- cumulus cell oocytes complex (COC) among women with poor ovarian reserve
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Infertility
Results Following the Vitrification of Human Oocytes Using 2 Methodologies
The investigators are going to compare embryo developmental rates of human eggs following freezing in two different freezing methods.
- Trial name
- NCT01033474
- Where
- Peru
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwest Center for Reproductive Sciences
Oocyte Cryopreservation
Paired Non-inferiority Study Comparing Overture Semi-automated Vitrification System ("DaVitri") to Standard Manual Process for Clinical Pregnancy Outcomes
This study will recruit 260 female recipients (and up to a maximum of 130 donors). This study is a sequel to the protocol CP-DV-000-GEN-003, entitled, "NON-INFERIORITY STUDY COMPARING OVERTURE SEMI-AUTOMATED VITRIFICATION SYSTEM…
- Trial name
- NCT06853418
- Testing
- Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Overture Life
Contraception
Cilostazol and Its Effects on Resumption of Meiosis in the Human Ovary
Combined oral contraceptive pills (COCs) are the most commonly used hormonal form of birth control in the United States with at least 87% of women of reproductive age reporting oral contraceptive use at some point in their lives…
- Trial name
- NCT01915069
- Testing
- Cilostazol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Infertility
The Cytogenetic Constitution of Embryos Resulting From Immature Oocytes (M1)
To examine the chromosomal number content in the blastomeres of embryos achieved from fertilization of immature oocytes at MI stage recruited following COH for IVF.
- Trial name
- NCT00544531
- Where
- Israel
- Volunteers
- 23,907 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
IVF, Overweight
The Effect of Over Weight on Oocytes Quality in IVF Patients
Obesity is an increasing worldwide problem and a risk factor for many diseases. The effect of obesity on female fertility has been extensively tested.
- Trial name
- IVF (NCT06331481)
- Testing
- Fullicular fluid for cytology and biocemical analysis
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Female Reproductive Problem, Infertility
Use of Corifolitropin Alfa in Oocyte Donors
The purpose of this study is to determine if corifollitropin alfa (long-term gonadotropin administration) is effective in a controlled ovarian stimulation protocol in oocyte donors compared to daily gonadotropin administration…
- Trial name
- NCT02213627
- Testing
- Corifollitropin alfa, Recombinant FSH, HP-hMG
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Infertility
The Effect of Follicular Flushing on Oocyte Retrieval Rate and Embryo Quality
Researchers will investigate the effect of flushing according to follicle size on the success of obtaining oocytes from a single follicle.
- Trial name
- NCT05584436
- Where
- Turkey (Türkiye)
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
In Vitro Maturation of Immature Oocytes
The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as…
- Trial name
- NCT00480337
- Testing
- In Vitro Maturation of immature oocytes
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility
Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
This is a randomized, double-blind, single center clinical trial study to compare oocyte competence and risk of ovarian hyperstimulation syndrome (OHSS) after receiving the standard dose of human chorionic gonadotropin (hCG)…
- Trial name
- NCT02310919
- Testing
- Low dose hCG plus FSH co-trigger, Standard dose of hCG
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Female
Exploratory Study Assessing Synchronisation of Egg Sacs With Degarelix
The main purpose of this clinical research study is to investigate if degarelix can synchronise the growth of the egg sacs in the ovaries and if degarelix has any effect on the lining of the womb.
- Trial name
- NCT00434122
- Testing
- Degarelix mid-luteal, 2.5 mg
- Where
- 4 sites in Belgium, Czechia and 1 more
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Fertilization
Artificial Assisted Activation Following in Fertilization Failure
Fertilization failure is a common problem in assisted reproductive Technology (ART). The main reason for fertilization failure of conventional IVF fertilization is sperm penetration failure, and the main reason of ICSI is…
- Trial name
- NCT04523103
- Testing
- Artificial Assisted Activation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Oocyte Retrieval, Postoperative Pain
Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
The central objective of this study will be to evaluate the relationship between estrogen levels and the pain following oocyte retrieval in women undergoing in vitro fertilization.
- Trial name
- NCT03105518
- Testing
- Fentanyl, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Infertility
Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
The purpose of this study is to determine if cryopreservation at the blastocyst stage followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear oocytes followed by post-thaw extended culture (PTEC)…
- Trial name
- NCT01247987
- Testing
- Blastocyst cryopreservation, Bipronuclear oocyte cryopreservation
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Vascular Endothelial Growth Factor Overexpression
Differential Regulation of VEGF, Cadherin, Angiopietin 2 by Trigger Oocyte Maturation With GnRHa vs hCG in Donors
Introduction OHSS still remains a complication of assisted reproduction treatments. hCG administration to trigger final oocyte maturation will release vascular mediators, being VEGF and other proteins such as VE-Cadherin or…
- Trial name
- NCT00848185
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
In Vitro Fertilization
The Influence of Dopamine Agonist Cabergoline on Oocyte Maturation
The dopamine agonist cabergoline inhibits phosphorylation of the vascular endothelial growth factor receptor-2(VEGFR-2), which prevent vascular endothelial growth factor (VEGF) overexpression and reduce the severity of Ovarian…
- Trial name
- NCT01065376
- Testing
- the timing cabergoline administration
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital