Clinical trials: Oocyte
In Vitro Fertilization, Infertility Assisted Reproductive Technology
Assessment of Reproductive Outcomes in Non-Male Factor Infertility Patients: Conventional in Vitro Fertilisation Versus Intracytoplasmic Sperm Injection
The aim of this clinical trial is to evaluate the efficiency of two fertilization techniques used in Assisted Reproduction: conventional In Vitro fertilization (cIVF) and Intracytoplasmic Sperm Injection (ICSI), in terms of…
- Trial name
- NCT06670586
- Testing
- conventional in vitro fertilization, intracytoplasmic sperm injection (ICSI)
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Maria Dolores Cuquerella Fernandez-Vazquez
Elective Fertility Preservation
FRench Elective Oocyte prEservation: a Multicenter Study thrEe Years Later
Previously reserved for pathological cases, oocyte cryopreservation for non-medical reason also named elective fertility preservation (EFP) is now authorized in France for women aged 29 to 37 following the revision of the…
- Trial name
- FREEZE-FR (NCT07138469)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 351 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility (IVF Patients), Oocyte Retrieval
Impact of the Operator Performing Oocyte Retrieval on the Cumulative Live Birth Rate
This is a monocentric retrospective observational study. The study investigates the impact of the operator performing the oocyte retrieval on the cumulative live birth rate (CLBR).
- Trial name
- OPU-CLBR (NCT06933901)
- Testing
- Oocyte retrieval
- Volunteers
- 19,500 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
ART
Importance of the Microtubule Cytoskeleton in Oocyte Competence
This study will assess if there are microtubule cytoplasmic features specifically associated with oocyte vitrification.
- Trial name
- NCT04546412
- Testing
- Vitrification and thawing
- Where
- Portugal
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Embryo Development
Effect of Abstinence Duration on Embryo Development
The aim the investigators study is to analyze the embryo development if oocytes of the participants are injected with sperm from a longer or shorter (2 hours) abstinence duration.
- Trial name
- NCT03323892
- Testing
- second masturbation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
ICSI, IVF
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
- Conditions
- ICSI, IVF, Normal Responders, Infertility Assisted Reproductive Technology
- Trial name
- DT-HCG-IVF (NCT07861399)
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Infertility, Pain
MEOPA Breathing Analgesia for Oocyte Retrieval(KALOVAL)
The purpose of this study is to assess pain, at or after oocyte retrieval, the effectiveness of self-controlled inhalation analgesia by nitrous oxide (N2O of 50% and 50% O2) by the patient compared to a local anesthesia combined…
- Trial name
- KALOVAL (NCT00853177)
- Testing
- MEOPA inhalation, xylocaine
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aging, Infertility
Effects of Resveratrol Supplementation on Oocyte Quality
The goal of this randomized, double-blind, placebo-controlled clinical trial is to verify if 3-month oral supplementation with resveratrol can enhance the oocyte quality in advanced maternal age women undergoing in vitro…
- Trial name
- NCT06235294
- Testing
- Resveratrol, Folic acid
- Volunteers
- 88 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Infertility, Female
CAPA In-vitro Oocyte Maturation (CUHK Medical Centre Limited)
In vitro oocyte maturation (IVM) is a mild-approach assisted reproductive technology (ART). Because of its simplicity, the more favorable financial implications (reduced cost) for patients, and the lower health risk profile of…
- Trial name
- NCT07083427
- Testing
- CAPA-IVM
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Intracytoplasmic Sperm Injection, Infertility, Male
Outcome of Using Sperm Bound to the Zona Pellucida of Immature Oocytes for Intracytoplasmic Sperm Injection (ICSI)
In vivo, the zona pellucida (ZP) of the oocyte can bind to normally functional sperm. The ZP-sperm interaction is one of the final steps of natural selection during their journey in the female reproductive tract.
- Trial name
- NCT05724979
- Testing
- ZP-binding
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Implantation Rate
Effect of Local Injury on Implantation
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
- Trial name
- NCT00846183
- Testing
- local injury
- Where
- Iran
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Polycystic Ovary Syndrome
IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer
A protocol was developed to improve pregnancy results after IVM compared to results from studies in the literature. Differences from most published protocols include the use of the Steiner-Tan needle to optimize oocyte…
- Trial name
- IVMprt (NCT04149496)
- Testing
- in vitro maturation of oocytes
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Bruce Rose, MD
ART, Child Development
Cognitive, Emotional, Communicative, and Motor Development in Children Born From IOC
The study focuses on children born after in vitro fertilization (IVF) of cryopreserved oocytes.
- Trial name
- NCT05906966
- Testing
- Phone contact
- Where
- Italy
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Female Infertility
LXR and Oocyte Meiosis Resumption
Previous studies in animal model showed clearly that lipid homeostasis influence oocyte meiosis resumption. However Liver X Receptors pathway has never been investigated in human ovocyte
- Trial name
- NCT03045315
- Testing
- IVF Procedure
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility
Using Cumulase for Denudation of Cycles With ≤ 8 Cumulus-oocytes Complexes
The cumulus-corona-oocyte complex (COCs) surrounds each oocyte and must be removed prior to intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03778736
- Testing
- Cumulase denudation
- Where
- 3 sites in Egypt
- Volunteers
- 586 people
- Sponsor
- Ibn Sina Hospital
Microdissection Testicular Sperm Extraction
Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction
This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.
- Trial name
- NCT07268235
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Clinique Ovo
Infertility
Single-center Prospective Cumulus Cell Test Study in rFSH Patients
Performing an additional non-invasive oocyte diagnostic test based on cumulus cell gene expression could improve the outcome of the ART cycle for rFSH stimulated patients
- Trial name
- NCT03663868
- Testing
- CC-Test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Sleep Disturbance
Esketamine vs Remimazolam for Postoperative Sleep Disturbance and Anxiety
To explore and compare the effects of esketamine and remimazolam on postoperative sleep disturbance in patients undergoing oocyte retrieval
- Trial name
- NCT06284668
- Testing
- normal Saline, Esketamine, Remimazolam
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Tianjin Medical University General Hospital
Infertility, in Vitro Fertilization
the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients
The goal of this clinical trial is to learn if psychological interventions alleviate the anxious emotion of women undergoing oocyte retrieval operation with general anesthesia.
- Conditions
- Infertility, in Vitro Fertilization, Mental Health, Anesthesia, General
- Trial name
- NCT06475690
- Testing
- Psychological interventions
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Cancer
Oocyte Cryopreservation Study (Egg Banking)
Women of reproductive age who seek to freeze eggs for future pregnancy attempts may be eligible to participate in a study investigating pregnancies that result from frozen eggs.
- Trial name
- NCT02396095
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania