Clinical trials: Oocytes
In Vitro Maturation of Oocytes
Fertilo In Vitro Research Study and Trial
The goal of this clinical trial is to evaluate the safety and efficacy of using Fertilo for In vitro maturation (IVM) in participants 18-35 years of age.
- Trial name
- FIRST (NCT06858111)
- Testing
- Fertilo, Medicult IVM
- Where
- 16 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Gameto, Inc.
Oocyte Retrieval, Postoperative Pain
Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
The central objective of this study will be to evaluate the relationship between estrogen levels and the pain following oocyte retrieval in women undergoing in vitro fertilization.
- Trial name
- NCT03105518
- Testing
- Fentanyl, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Oocyte Retrieval
Preoperative Indomethacin and Paracetamol for Pain Management During Oocyte Retrieval in IVF Patients
This is a randomized controlled trial evaluating the efficacy of preoperative analgesic medications - Indomethacin (100 mg per rectum) and Paracetamol/Acamol (1,000 mg intravenously) - for pain management during oocyte retrieval…
- Trial name
- NCT07536425
- Testing
- Indomethacin 100Mg Suppository, Paracetamol / Acetaminophen
- Where
- Israel
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Oocyte Cryopreservation
Optimization of Oocyte Warming Protocols
This is a retrospective study with a sibling design comparing new oocyte thawing protocols (rapid and ultra-rapid) with the traditional method
- Trial name
- OVOfast (NCT07105891)
- Testing
- Thawing protocol
- Where
- Italy
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Oocyte Maturation
Follicular Fluid Exosome miRNA During Oocyte Maturation
Folliculogenesis involves the recruitment of primordial follicles into a group of growing follicles in which eventually one follicle is selected, matured and ovulated.
- Trial name
- NCT04382872
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Oocyte Cryopreservation
Paired Non-inferiority Study Comparing Overture Semi-automated Vitrification System ("DaVitri") to Standard Manual Process for Clinical Pregnancy Outcomes
This study will recruit 260 female recipients (and up to a maximum of 130 donors). This study is a sequel to the protocol CP-DV-000-GEN-003, entitled, "NON-INFERIORITY STUDY COMPARING OVERTURE SEMI-AUTOMATED VITRIFICATION SYSTEM…
- Trial name
- NCT06853418
- Testing
- Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Overture Life
Infertility Assisted Reproductive Technology, Oocyte Retrieval
ART Cycle Outcomes When Only 1 to 3 Oocytes Are Retrieved
This is a monocentric retrospective observational study. The study focuses on the women who underwent Assisted Reproductive Technology (ART) cycles with poor ovarian response (POR), defined as <4 oocytes retrieved.
- Trial name
- POR (NCT06950476)
- Testing
- Oocyte Retrieval
- Volunteers
- 3,761 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Infertility (IVF Patients), Oocyte Retrieval
Impact of the Operator Performing Oocyte Retrieval on the Cumulative Live Birth Rate
This is a monocentric retrospective observational study. The study investigates the impact of the operator performing the oocyte retrieval on the cumulative live birth rate (CLBR).
- Trial name
- OPU-CLBR (NCT06933901)
- Testing
- Oocyte retrieval
- Volunteers
- 19,500 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Oocyte, Zona Pellucida
To Investigate the Relationship Between the Viscoelastic Properties of the Zona Pellucida of Human Oocyte and the Blastocyst Utilization Rate
In in vitro fertilization (IVF) treatment, oocyte quality is one of the key factors influencing the success rate of fertilization.
- Conditions
- Oocyte, Zona Pellucida, Viscoelastic Property
- Trial name
- NCT06839495
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Inti Labs
Stimulation in the Ovary, Embryo
Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.
The PPOS protocol (Progestin-primed Ovarian Stimulation) involves avoiding ovulation during ovarian stimulation with progesterone.
- Conditions
- Stimulation in the Ovary, Embryo, Oocyte, Oocyte Retrieval
- Trial name
- PPDUO (NCT06637189)
- Testing
- Ganirelix, Medroxyprogesterone Acetate 10 MG
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ginefiv
Increased Oocyte Death, in Vitro Maturation
GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)
Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM).
- Conditions
- Increased Oocyte Death, in Vitro Maturation, GREM1 Gene Mutation, Cumulus Cell
- Trial name
- NCT06315777
- Testing
- cumulus cell oocytes complex (COC) among women with poor ovarian reserve
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Oocyte Donors, Oocyte Donation
Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone
The last decade has shown a progressive scientific interest for new strategies to improve the outcomes of controlled ovarian stimulation (COS).
- Trial name
- LadyDe (NCT05521828)
- Testing
- Follitropin delta (Rekovelle), Duphaston, GnRH agonist (Gonapeptyl)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Ovarian Stimulation, Human Chorionic Gonadotropin
The Effect of Dual Trigger (GnRH Agonist + hCG) for Final Maturation in Oocyte Donors With History of a Previous Cycle With Suboptimal Response to GnRH Agonist Only Trigger
The goal of this clinical trial is to compare GnRH-agonist trigger with dual GnRH-agonist and HCG trigger in oocyte donors. The main questions it aims to answer are: Maturation rate (Metaphase II/ Total number of COCs collected)…
- Conditions
- Ovarian Stimulation, Human Chorionic Gonadotropin, Oocyte Donors
- Trial name
- NCT06142708
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), GnRH-agonist only trigger
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embryolab Fertility Clinic
Non-viable Oocytes, Extra Spermatozoa
Evaluation of Discarded Laboratory Pathological Specimens and Media
The researchers propose to investigate the causes, incidence, and time-related events of chromosomal and physiologic abnormalities as they relate to patient diagnosis, fertility drugs utilized, and in vitro laboratory culture…
- Conditions
- Non-viable Oocytes, Extra Spermatozoa, Seminal Fluid, Granulosa Cells
- Trial name
- NCT01219439
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Oocyte Retrieval
Comparison of Two Different Anesthesia Methods in IVF Procedure
In this study; during the oocyte retrieval procedure, it was aimed to compare two different general anesthesia methods, in which propofol was administered as infusion according to the patient's Bispectral index system (BIS) value…
- Trial name
- NCT05631925
- Testing
- propofol bolus, propofol infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Acibadem University
the Number of Mature Oocytes
Trigger Time in Advanced Maternal Age Patients With Low AMH
The investigators want to verify if advanced maternal age patients with a low Anti-Müllerian hormone (AMH) level may benefit from an early trigger time (compared to a late trigger).
- Trial name
- NCT03740880
- Testing
- Dual trigger
- Where
- United Arab Emirates
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Preeclampsia, Oocyte-donation Pregnancies
Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
- Trial name
- NCT04731012
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hysteroscopy, Oocyte Recipients
Hysteroscopy With Fundus Uterus Scratching Incision VS Office Hysteroscopy Before ET With Donor Eggs
A prospective randomised control trial of the impact of the fundus edometrial incision during hysteroscopy in oocyte recipients.
- Trial name
- NCT04580056
- Testing
- Uterine fundus endometrial incision during hysteroscopy
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Oocyte Competence
Modulation Contrast Microscopy Imaging for Oocyte Quality Assessment
The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes).
- Trial name
- NCT03683290
- Testing
- Image acquisition and analysis
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
Invitro Fertilization, Diminished Ovarian Reserve
Effect of Follicular Flushing in Patients With Mono-follicular Growth Undergoing In Vitro Fertilization
Retrieval of an oocyte from a follicle relies on the release of the cumulus-oocyte-complex (COC) from the follicular wall into the lumen, thereby allowing aspiration by a needle.
- Conditions
- Invitro Fertilization, Diminished Ovarian Reserve, Oocyte
- Trial name
- NCT03831542
- Testing
- direct follicular aspiration, follicular flushing
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centrum Clinic IVF Center