Clinical trials: Open Abdominal Surgery
Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Individualized Perioperative Open Lung Ventilatory Strategy
The purpose of this study is to determine whether individualized ventilatory management combining the use of low tidal volumes, alveolar recruitment maneuvers, individually titrated positive end-expiratory pressure and…
- Trial name
- iPROVE (NCT02158923)
- Testing
- Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP
- Where
- 7 sites in United States, Argentina and 2 more
- Volunteers
- 920 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Ulcerative Colitis, Familial Polyposis
An Evaluation of SprayShield in Reducing Post-Operative Adhesion Formation Following Major Open Abdominal Surgery
This will be a prospective, multi-center, randomized, single blind study to collect and evaluate post-market clinical data on the SprayShield Adhesion Barrier System as an adjuvant to good surgical technique for the reduction of…
- Trial name
- NCT01002287
- Testing
- SprayShield Adhesion Barrier System, Good Surgical Technique Alone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Integra LifeSciences Corporation
Postoperative Complication
Effect of Remote Ischemic Preconditioning on Postoperative Complications in Visceral Surgery
Remote Ischemic Preconditioning (RIPC) is mediated by intermittent brief episodes (5-10 minutes) of short ischemia in a limb (i.e. arm), followed by reperfusion.
- Trial name
- RIPC (NCT02375269)
- Testing
- RIPC with a tourniquet
- Where
- Switzerland
- Volunteers
- 526 people
- Sponsor
- University of Zurich
Hernia, Inguinal
Pain and Quality of Life After Inguinal Hernia Repair: Laparoscopic Versus Open Repair.
This investigation will be a double-armed, randomized prospective study designed to compare open (Lichtenstein Technique) versus laparoscopic (TAPP) repair of primary unilateral inguinal hernia.
- Trial name
- QoL-TAPP (NCT04211142)
- Testing
- Laparoscopic Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP repair), Open Inguinal Hernia Repair (Lichtenstein repair)
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Hospital Clinic of Barcelona
Respiratory Insufficiency, Postoperative Pulmonary Complications
Mobilization Immediate After Abdominal Surgery
Advances in surgical technique have led to a more complex surgery on patients with more serious comorbidities and the risk of postoperative pulmonary complications (PPC) is considerable .
- Trial name
- NCT02929446
- Testing
- Mobilisation, Mobilisation and breathing exercises
- Where
- Sweden
- Volunteers
- 285 people
- Sponsor
- Karolinska Institutet
Pneumoperitoneum
Intra-abdominal Pressure and Dynamic Preload Variables
Dynamic preload variables like pulse-pressure and stroke volume variation may be used to predict fluid responsiveness in patients during controlled ventilation.
- Trial name
- NCT02690688
- Testing
- determination of dynamic preload variables
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Pain Management After Surgery
Open TAP-block in Pediatric Abdominal Surgery
The goal of this trial is to evaluate an open TAP-block vs continuous administration of local anestetic via a wound catheter for postoperative pain management in patients 1-15 years of age undergoing open abdominal surgery.
- Trial name
- NCT07352683
- Testing
- TAP-block, Wound catheter
- Where
- Sweden
- Volunteers
- 88 people
- Sponsor
- Uppsala University
Bowel Surgery
Restricted Fluid Regimen in Open Abdominal Bowel Surgery
Liberal intravenous fluid resuscitation during open abdominal surgery may predispose the patients to multiorgan dysfunction, prolong hospital stay and increase postoperative morbidity.
- Trial name
- NCT00456703
- Testing
- intraoperative fluid management, fluid restriction
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Peritoneal Neoplasms, Hyperthermic Intraperitoneal Chemotherapy
Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
Introduction Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is considered as the standard of care for the treatment of peritoneal metastases.
- Conditions
- Peritoneal Neoplasms, Hyperthermic Intraperitoneal Chemotherapy, Intraoperative Care, Fluid Therapy
- Trial name
- ALBUCHIP (NCT06351475)
- Testing
- Intra-operative albumin administration, Control
- Where
- 8 sites in France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm Enlargement
Italian Multicenter Database for Open Conversions After EVAR
Late endovascular abdominal aneurysm repair (EVAR) complications not amenable to endovascular correction can undergo either late open conversion (LOC) or semi-conversion (SC).
- Trial name
- iConveRt (NCT04299984)
- Testing
- Open Conversion after EVAR, SemiConversion after EVAR
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Aortic Aneurysm, Abdominal, Pain
Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery
The ETAP study aim to assess the effect of the addition of an ultrasound-guided transversus abdominis plane (TAP) block to a multimodal intravenous analgesia protocol on the postoperative pain control in open surgical repair of…
- Conditions
- Aortic Aneurysm, Abdominal, Pain, Anesthesia, Local
- Trial name
- ETAP (NCT02292667)
- Testing
- TAP block, PCA with Chlorhydrate of Morphine, Acetaminophen
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Ventral Hernia, Incisional Hernia
Comparison of Sublay and Onlay Mesh Repair in Ventral Hernia
This study is designed to compare two different surgical methods for repairing ventral abdominal wall hernias: sublay mesh repair and onlay mesh repair.
- Trial name
- NCT07140471
- Testing
- Onlay Mesh Repair, Sublay Mesh Repair
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Sana Ehsan ullah
Pain, Postoperative, Hernia, Ventral
An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries
This is a multicenter, Phase 3, open-label, safety, tolerability, and characterization of pharmacokinetics study of the INL 001 (bupivacaine HCl) implant, at 300 mg, in patients following various soft-tissue surgeries: open…
- Conditions
- Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy
- Trial name
- NCT04785638
- Testing
- INL-001 (bupivacaine hydrochloride) implant
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Innocoll
Elective Abdominal Aortic Aneurysm
Elective Abdominal Aortic Aneurism - Open Versus Endovascular Repair
Abdominal aortic aneurysm (AAA) is a life threatening disease. There is a consensus to propose surgical repair in patients with a reasonable operative risk when the AAA exceeds 5 cm in diameter.
- Trial name
- ACE (NCT00224718)
- Testing
- Endovascular repair (with endograft), Open repair
- Where
- France
- Volunteers
- 306 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder)
Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery
NOTES access is safe and feasible in the controlled human setting and comparable to standard-of-care surgical techniques. NOTES exploration of the abdomen provides adequate visualization comparable to laparoscopy.
- Conditions
- Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder), Foreign Body in Esophagus, Prostatic Diseases
- Trial name
- NOTES (NCT00484783)
- Testing
- Natural Orifice Transluminal Endoscopic Surgery (NOTES), Natural Orifice Translumenal Endoscopic Surgery (NOTES)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Biliary Tract Surgical Procedures, Pancreaticoduodenectomy
Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Major Abdominal Surgery
Tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in various types of major surgery (orthopedic surgery, spine surgery, cardiopulmonary bypass, liver resections, and gynecological…
- Conditions
- Biliary Tract Surgical Procedures, Pancreaticoduodenectomy, Esophagectomy, Colectomy
- Trial name
- NCT00827931
- Testing
- Tranexamic acid + Standard of Care, Standard of Care
- Where
- 2 sites in India
- Volunteers
- 94 people
- Sponsor
- Pfizer
Complex Abdominal Aortic Aneurysm, ie. Juxtarenal or Suprarenal Aortic Aneurysms, Treated by Fenestrated Endovascular Aortic Aneurysm Repair or Open Repair
Cost-utility Analysis of Fenestrated Aortic Stents Versus Open Surgery for the Treatment of Complex Abdominal Aortic Aneurysms
Introduction: Complex abdominal aortic aneurysms (CAA) are defined as abdominal aneurysms that are anatomically unsuitable for a standard endovascular repair because of a short infrarenal neck or no infrarenal neck.
- Trial name
- ORFEVAR (NCT04671732)
- Testing
- Fenestrated endovascular aortic aneurysm repair, open repair of abdominal aortic aneurysm.
- Where
- France
- Volunteers
- 492 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sternal Instability After Median Sternotomy
Comparison of Supra-abdominal ex Versus Infra-abdominal With Laser on Median Sternotomy
the aim of this study is to find out the differences between the effect of supra- abdomen exercises and the effect of infra-abdomen exercise combined with LASER And the effect of LOW LEVEL LASER only on sternal instability.
- Trial name
- LLL/CABG (NCT07381387)
- Testing
- supra abdomen resisted exercises combined with LLL + Traditional cardiac rehabilitation program of phase one, ): patients will infra abdomen resisted exercises combined with LLL +Traditional cardiac rehabilitation program of phase one., patients will receive Traditional cardiac rehabilitation program of phase one with LLL
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Beni-Suef University
Elective Endovascular Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours, Elective Open Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours
The Hypotension Prediction Index Versus Standard Advanced Haemodynamic Monitoring in Patients Undergoing Major Aortic Surgery
The standard procedure during general anesthesia is to monitor vital functions, including cardiovascular functions such as cardiac electrical activity, using continuous ECG recording, blood pressure measurement with a…
- Trial name
- HYPE-AORTA (NCT07510451)
- Testing
- HPI guided heamodynamic monitoring, Standard Heamodynamic Managament according to APCO Monitoring
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
Colorectal Neoplasm, Colorectal Cancer
Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases
This is a multicentre, open-label, parallel-group, phase II-III, superiority study that randomises patients with isolated resectable colorectal peritoneal metastases in a 1:1 ratio to receive either perioperative systemic therapy…
- Conditions
- Colorectal Neoplasm, Colorectal Cancer, Colorectal Neoplasms Malignant, Colorectal Carcinoma
- Trial name
- CAIRO6 (NCT02758951)
- Testing
- Perioperative systemic therapy, Perioperative CAPOX-bevacizumab, Perioperative FOLFOX-bevacizumab
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 358 people
- Sponsor
- Koen Rovers