Clinical trials: Open Fractures
Osteo Arthritis Shoulders, Osteonecrosis
Exactech Shoulder Post Market Clinical Follow-up Study
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time.
- Conditions
- Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
- Trial name
- NCT05603728
- Where
- 40 sites in United States, Canada and 4 more
- Volunteers
- 20,000 people
- Sponsor
- Exactech
Tibial Fractures, Open Fractures
Safety and Performance of BonyPid-1000™ in the Treatment of Gustilo I, II, IIIA and IIIB Tibial Open Fractures
This is a prospective, multi-national, multicenter, randomized, two arms, single blind, Standard of Care (SOC) controlled, with blinded central reading center study.
- Trial name
- NCT02491047
- Testing
- BonyPid-1000, Standard of Care (SOC) treatment
- Where
- 9 sites in Israel, Philippines
- Volunteers
- 51 people
- Sponsor
- PolyPid Ltd.
Blood Loss Following Open Femur Fracture Surgery
The Effect of Tranexamic Acid on Blood Loss and Transfusion Requirements Following Open Femur Fracture Surgery
The purpose of this study is to determine the effect of tranexamic acid (TXA) on blood loss and transfusion requirements in patients with femur fractures requiring open surgical approaches.
- Trial name
- NCT03679481
- Testing
- Tranexamic acid (TXA), Normal saline
- Sponsor
- The University of Texas Health Science Center, Houston
Pain
A Pilot Study of TRV130 for the Treatment of Fracture Pain
The primary objective is to evaluate the analgesic efficacy of TRV130 for moderate to severe acute pain in patients presenting to the emergency department (ED) with a suspected/known, unilateral, closed long bone fracture.
- Trial name
- NCT02520297
- Testing
- TRV130
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Trevena Inc.
Pilon Fractures, Fractures
Surgery of the Pilon Fractures
The assessment consists in comparing the osteosynthesis plate with minimally invasive technique versus open reduction and internal fixation.
- Conditions
- Pilon Fractures, Fractures, Bone, Leg Injuries
- Trial name
- MICOPIL (NCT03367169)
- Testing
- minimally invasive method, open reduction method
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Fracture, Pain
RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child
Randomized double blind Trial with the aim to estimate effectiveness of two therapeutic regimes per os on pain due to not compound bone fractures in child 4-17 years old: ketorolac 0,5 mg/kg (1 drop every 2 Kg) tramadol 2,5 mg/Kh…
- Trial name
- NCT00560443
- Testing
- ketorolac, tramadol
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- IRCCS Burlo Garofolo
Pain, Acute
SOFT Block Versus Spinal Anesthesia in Patientsusing Ilizarov External Fixator
Peripheral nerve block is an ideal choice for lower limb surgery because of the peripheral site of the surgical procedure and the ability to block pain pathways at multiple levels.
- Trial name
- NCT03450798
- Testing
- SOFT block group, spinal anesthesia group
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Ain Shams University
Fractures
CT Analysis of Structural Buttresses in the Traumatised Nose
Hypothesis: There are 5 support buttresses in the complex osteocartilaginous architecture of the nose. 1. The membranous septum; 2. The Right nasal bone; 3. The Left nasal bone; 4. The perpendicular plate of the ethmoid; 5.
- Trial name
- NCT01136616
- Where
- Singapore
- Volunteers
- 67 people
- Sponsor
- National University Hospital, Singapore
Tibial Fractures
Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT03826784
- Testing
- BHA
- Where
- United States
- Sponsor
- Carmell Therapeutics Corporation
Tibial Plateau Fracture
Clinical Efficacy of Open Reduction and Suture Bridge Fixation for PCL Tibial Avulsion Fractures
Abstract Background: Posterior cruciate ligament (PCL) tibial avulsion fractures significantly impair knee function; however, optimal surgical fixation approaches are not agreed upon.
- Trial name
- fracture (NCT06918171)
- Testing
- Clinical Efficacy of Open Reduction and Anchor Suture Bridge Fixation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Fractures, Bone, Trauma Injury
Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients
The purpose of this study is to determine whether an indocyanine green (ICG) fluorescence imaging system (cBPI) can be used to provide surgeons with information about bone health or bone blood flow.
- Trial name
- cBPI (NCT06793644)
- Testing
- Immunofluorescence Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tibial Fracture, Soft Tissue Injury
Hyperbaric Oxygen in Lower Leg Trauma
Study hypothesis :Hyperbaric Oxygen may prevent complications and improve outcomes in severe lower limb trauma. We propose to investigate this hypothesis by conducting an International multi centre randomised control trial of…
- Trial name
- NCT00264511
- Testing
- Hyperbaric Oxygen Treatment
- Where
- 10 sites in United States, Australia and 7 more
- Volunteers
- 120 people
- Sponsor
- Bayside Health
Trauma, Fractures, Open
The New Skin Stretching Device for Treatment of Limb Tension Wounds
A randomized controlled trial is performed to evaluate the effectiveness and safety of the Skin Stretching Device (SSD) on limb tension incision closure by comparing whether the differences in wounds area, wounds closure time and…
- Conditions
- Trauma, Fractures, Open, Wounds and Injuries, Skin Expander
- Trial name
- SSDRCT (NCT03141502)
- Testing
- Skin stretching device (SSD), Skin grafting
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Pertrochanteric Fracture, Intertrochanteric Fractures
Pertrochanteric Fracture Fixation In Elderly Adults Using Proximal Femoral Nail Anti-rotation (HERACLES) With a T-shaped Parallel Blade: A New Design
This is a prospective case series of elderly adult patients sustaining pertrochanteric fractures who will be treated by a proximal femoral nail with a non-helical (straight) blade.
- Conditions
- Pertrochanteric Fracture, Intertrochanteric Fractures, Pertrochanteric Fracture of Femur, Closed, Pertrochanteric Fracture of Femur, Open
- Trial name
- Heracles PFN (NCT03911180)
- Testing
- Proximal femoral nail with straight parallel blade
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ilocos Training and Regional Medical Center
Chronic Postsurgical Pain
CSF Single-cell Sequencing and Proteomics of Chronic Postsurgical Pain in Patients With Lower Limb Fractures
The purpose of this study is to assess the proteomics and transcriptomic differences between pain-free control subjects and patients with chronic postoperative pain through single-cell sequencing technology.
- Trial name
- NCT06126289
- Volunteers
- 20 people
- Sponsor
- Xuzhou Central Hospital
Proximal Humeral Fracture
Proximal Humerus Fractures: A Retrospective Analysis
The purpose of this study is to evaluate preoperative objective measurements of patients with a proximal humerus fracture and operative objective measurements to determine if there is any effect to postoperative outcomes.
- Trial name
- PHFx (NCT03637608)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- The Orthopaedic Research & Innovation Foundation
Distal Radius Fracture, Post Operative Pain Control
Single Shot vs Catheter Infraclavicular Brachial Plexus Block After Distal Radius Fracture Repair
The purpose of this study is to compare infraclavicular brachial plexus shot single shot block to continuous catheter nerve block done in adult patients who have under gone surgery to repair distal radius fractures.
- Trial name
- NCT02744352
- Testing
- 20ml bolus of 0.5% ropivicaine, 0.2% of ropivacaine at 8 milliliter/hour
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Postmenopausal Osteoporosis
A Study of Romosozumab (EVENITY®) in Postmenopausal Women in India With Osteoporosis at a High Risk of Fracture.
The primary objective of this study is to characterize safety and tolerability of romosozumab in postmenopausal women with osteoporosis and a high risk of fracture in India.
- Trial name
- NCT06079476
- Testing
- Romosozumab
- Where
- 10 sites in India
- Volunteers
- 100 people
- Sponsor
- Amgen
Osteoporosis
The Study of the Early Administration of Alendronate on Prevention of Bone Loss After Hip Fracture.
To determine whether administration of Alendronate early is more effective than late in the prevention of osteoporosis following a hip fracture
- Trial name
- NCT00346190
- Testing
- Alendronate
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre