Clinical trials: Operable Breast Neoplasms
Breast Cancer
Chemotherapy Followed by Surgery in Treating Women With Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of doxorubicin and docetaxel followed by surgery in…
- Trial name
- NCT00003953
- Testing
- filgrastim, CMF regimen, docetaxel
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Epirubicin in Treating Women Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as epirubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00253500
- Testing
- pegfilgrastim, epirubicin hydrochloride, conventional surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Case Comprehensive Cancer Center
Invasive Breast Cancer
A Study of AC Followed by a Combination of Paclitaxel Plus Trastuzumab or Lapatinib or Both Given Before Surgery to Patients With Operable HER2 Positive Invasive Breast Cancer
The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined…
- Trial name
- NCT00486668
- Testing
- doxorubicin, cyclophosphamide, paclitaxel
- Where
- 110 sites in United States, Canada and 1 more
- Volunteers
- 529 people
- Sponsor
- NSABP Foundation Inc
Invasive Breast Carcinoma, Primary Invasive Breast Cancer
Capecitabine in Women With Operable Breast Cancer
The purpose of this study is to find out what effects (good and bad) taking capecitabine for 12 weeks before surgery will have on women with breast cancer.
- Conditions
- Invasive Breast Carcinoma, Primary Invasive Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT00148720
- Testing
- Capecitabine
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Exercise Intervention Study for Early-Stage Breast Cancer Patients Receiving Neoadjuvant Therapy.
To determine the effects of endurance exercise training on cardiopulmonary fitness in breast cancer patients undergoing neoadjuvant chemotherapy.
- Trial name
- NCT00405678
- Testing
- Exercise Training, Chemo only
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Duke University
Breast Cancer
Sunitinib in Treating Patients With Newly Diagnosed Stage II or Stage III Breast Cancer That Can Be Removed by Surgery
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00482755
- Testing
- sunitinib malate, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- NCIC Clinical Trials Group
Breast Cancer Female
Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast Cancer
A short pre-surgical non-therapeutic trial involving postmenopausal women with newly diagnosed eR+, HeR2-negative operable breast cancers.
- Trial name
- NCT03747042
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Primary Breast Cancer
Alternative Non-cross-resistant Adjuvant Chemotherapy for Operable Breast Cancer Non-response to Primary Chemotherapy
The purpose of this phase Ⅲ, multi-center, prospective, open-label, randomized,controlled study is to determine whether alternative non-cross-resistant adjuvant chemotherapy can increase distant disease free survival(DDFS) in…
- Trial name
- NCT01019616
- Testing
- paclitaxel/anthracycline
- Where
- 7 sites in China
- Volunteers
- 400 people
- Sponsor
- Tao OUYANG
Breast Cancer
Chemotherapy With or Without Bevacizumab in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer That Can Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00408408
- Testing
- bevacizumab, capecitabine, cyclophosphamide
- Where
- 442 sites in United States, Canada and 1 more
- Volunteers
- 1,206 people
- Sponsor
- NSABP Foundation Inc
Primary Operable Breast Cancer
Perioperative Administration of COX 2 Inhibitors and Beta Blockers to Women Undergoing Breast Cancer Surgery
Surgery for breast cancer has a major role in enhancing long term survival and cure, but several physiological aspects associated with surgery are implicated as enhancing tumor spread and formation of distant metastases.
- Trial name
- NCT00502684
- Testing
- Propranolol, etodolac
- Where
- 3 sites in Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Cancer of the Breast
Sentinel Node Biopsy and Axillary Sampling in Operable Breast Cancer
The advent of mammography and increased awareness of breast cancer has resulted in detection of smaller tumors, the majority of which would not have had metastasized to the axillary lymph nodes.
- Trial name
- NCT00128362
- Testing
- Radio-guided sentinel node biopsy, Axillary sampling
- Where
- India
- Volunteers
- 478 people
- Sponsor
- Tata Memorial Hospital
HER2/Neu Positive, Stage IA Breast Cancer
Combination Chemotherapy and Paclitaxel Plus Trastuzumab in Treating Women With Palpable Breast Cancer That Can Be Removed by Surgery
This randomized phase III trial is studying giving fluorouracil together with epirubicin and cyclophosphamide followed by paclitaxel and trastuzumab to see how well it works compared with giving paclitaxel together with…
- Conditions
- HER2/Neu Positive, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT00513292
- Testing
- Cyclophosphamide, Epirubicin Hydrochloride, Laboratory Biomarker Analysis
- Where
- 115 sites in United States, Puerto Rico
- Volunteers
- 280 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Bevacizumab With or Without Cyclophosphamide and Methotrexate: A Pilot Study in Women With Operable Breast Cancer
The purpose of this research study is to study the effects (good and bad) of bevacizumab alone, bevacizumab with low-dose continuous chemotherapy (called metronomic chemotherapy), or bevacizumab with capecitabine, on you and your…
- Trial name
- NCT00121134
- Testing
- Bevacizumab, Cyclophosphamide, Methotrexate
- Where
- 5 sites in United States
- Volunteers
- 164 people
- Sponsor
- Harold J. Burstein, MD, PhD
Breast Cancer
Coagulation Parameters in Postmenopausal Breast Cancer Patients Under Adjuvant Hormonal Therapy
The objective of the study is to monitor the changes of blood coagulation parameters in postmenopausal patients who are treated with adjuvant Hormonal Therapy for a total of 5 years.
- Trial name
- COPA (NCT00814034)
- Where
- 2 sites in Greece
- Volunteers
- 306 people
- Sponsor
- Hellenic Breast Surgeons Society
Breast Cancer
Fluorescein for Sentinel Lymph Node Biopsy (SLNB) in Breast Cancer
The study goal is to develop a new method of intraoperative lymphatic mapping with fluorescent contrast agents to improve the outcome of therapeutic breast cancer surgery.
- Trial name
- NCT01614184
- Testing
- Fluorescein
- Sponsor
- University of Utah
Breast Cancer
Maintenance Treatment With Capecitabine Versus Observation in Breast Cancer Patients
This is a prospective, open-label, randomized phase III study assessing adjuvant capecitabine after standard chemotherapy for patients with early triple negative breast cancer.
- Trial name
- NCT00130533
- Testing
- Capecitabine
- Where
- 48 sites in Spain
- Volunteers
- 876 people
- Sponsor
- Spanish Breast Cancer Research Group
Breast Cancer
Docetaxel in Breast Cancer
Primary objective : To compare disease-free survival after treatment with docetaxel in combination with doxorubicin and cyclophosphamide to doxorubicin and cyclophosphamide followed by docetaxel in operable adjuvant breast cancer…
- Trial name
- NCT00312208
- Testing
- docetaxel, doxorubicin, cyclophosphamide, Docetaxel,doxorubicin, cyclophosphamide
- Where
- 37 sites in United States, Argentina and 35 more
- Volunteers
- 3,299 people
- Sponsor
- Sanofi
Breast Neoplasms
Primary Progesterone Therapy for Operable Breast Cancer
The purpose of this study is to test the effect of primary progesterone on overall and disease free survival in women with operable breast cancer.
- Trial name
- NCT00123669
- Testing
- 500 mg of depot hydroxy-progesterone
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Tata Memorial Hospital
Breast Cancer
A Study to Evaluate the Biological Activity of R1507 in Women With Operable Breast Cancer
This 2 part study will explore the pharmacodynamic effects of R1507 in breast cancer tumor cells in female patients with operable breast cancer.
- Trial name
- NCT00882674
- Testing
- RG1507
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer Early Stage Breast Cancer (Stage 1-3), HER2
A Composite Assay for HER2-positive Early-stage Breast Cancer Management
The goal of this observational study is to assess the prognostic value of a genomic classifier (S18) and its refined version (S*) in women with early-stage HER2-positive breast cancer.
- Trial name
- HERCard (NCT06762977)
- Where
- 2 sites in Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano