Clinical trials: Ophthalmic Disorders
Tomography
UNITY DX Cornea Study
The purpose of this study is to validate the clinical measurement performance of an investigational biometer. Subjects will undergo multiple measurements of the eye, and the agreement, repeatability, and reproducibility of…
- Trial name
- NCT07768735
- Testing
- UNITY DX, ANTERION
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Glaucoma, Retinal Disease
Agreement and Precision Study of the Nidek Mirante
This study is a prospective comparative, randomized, single center study to gather agreement and precision of the Nidek Mirante OCT with SLO and Anterior Segment Imaging capabilities in comparison to the Optovue RTVue XR Avanti…
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT04318132
- Testing
- Nidek Mirante, Optovue RTVue XR Avanti, Optos P200DTx
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Dry Eye Disease
Evaluating the Efficacy of Dry Eye (DE) Disease Treatment Using Novel Tear Film Imager (TFI)
Dry Eye disease signs and symptoms are reduced in patients who receive topical steroids and topical hyaluronic acid. AdOM's Tear Film Imager measurements are reproducible and it can diagnose the dry eye disease state in a single…
- Trial name
- NCT04670263
- Testing
- Tear Film Imager
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Adom Advanced Optical Technologies Ltd.
Visual Field Defect, Peripheral
Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease
The purpose of this study is to test a new way of measuring the peripheral vision (called a visual field test) using a device which can be worn as goggles rather than being a large instrument the patient must sit at.
- Trial name
- NCT05150197
- Testing
- VisuALL, Humphrey Visual Field
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Oral Lichen Planus, Mucous Membrane Pemphigoid
Dexamethasone Solution and Dexamethasone in Mucolox™
Topical steroid therapy is considered the first line of treatment for Oral Inflammatory Ulcerative Diseases with current treatment regimens requiring multiple application or rinses daily.
- Conditions
- Oral Lichen Planus, Mucous Membrane Pemphigoid, Pemphigus Vulgaris, Chronic Graft-versus-host-disease
- Trial name
- NCT04540133
- Testing
- dexamethasone 0.5mg/5ml solution, dexamethasone 0.5mg/5ml solution in Mucolox™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Macular Degeneration, Age-Related, Diabetic Retinopathy
Visual Enhancement Device in Low Vision Patients
This study will be a prospective, non-randomized study of low-vision individuals diagnosed with either age-related macular degeneration (AMD) or diabetic macular edema with ETDRS visual acuity from 20/60 to 20/400 in both eyes…
- Trial name
- Evergaze (NCT03794752)
- Testing
- Head-Mounted Visual Enhancement Device
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Age Related Macular Degeneration
High-Resolution Ultrasound Imaging of the Retina and Choroid for Detection on Age Related Macular Degeneration
The macula is the site of central vision within the retina. The retina is oxygenated by the underlying choroid. These tissues are less than 1 mm thick in total.
- Trial name
- NCT00277784
- Testing
- Ultrasound examination
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Blindness Congenital
Comparison of Balance and Coordination Parameters of Visually Impaired and Healthy Individuals
The aim of this [observational study] is to examine balance in multiple aspects by comparing balance, coordination, and gait parameters between congenitally blind individuals and healthy individuals with multiple scales.
- Trial name
- NCT06687915
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Dry Eye Syndromes
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).
This study will evaluate and compare 2 artificial tears in their ability to reduce post LASIK dry eye signs and symptoms. The secondary endpoint of this study is to evaluate refractive regression in these patients.
- Trial name
- NCT00620893
- Testing
- PEG- 400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Keratoconus
Epithelial Thickness Map
In keratoconic eyes, the corneal epithelium shows a localized thinning over the cone that is surrounded by an annulus of epithelial thickening.
- Trial name
- NCT04578184
- Testing
- Corneal epithelial thickness measurements
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Myopia
Evaluate the Safety and Efficacy of Two Types of Circular Column Modulated Lenses for Delaying the Progression of Myopia
Clinical trial to evaluate the safety and effectiveness of two kinds of ring band cylindrical lens in delaying the progression of myopia
- Trial name
- NCT05288335
- Testing
- Circular cylindrical mirror modulated frame glasses (compact), Circular cylindrical mirror modulated frame glasses (strong defocus), single vision frame glasses
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Myopia, Refractive Error
Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface
The purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across three lens care regimens in new contact lens wearers.
- Trial name
- NCT01250925
- Testing
- ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
- Where
- 2 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Normal Tension Glaucoma
Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
A randomized, multicenter, investigator-masked prospective study of NTG patients currently on latanoprost 0.005% monotherapy, to study the effect of IOP change with the introduction of netarsudil 0.02% vs brimonidine 0.1%.
- Trial name
- NCT06449352
- Testing
- Netarsudil, Brimonidine
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Westlake Eye Specialists
Diabetic Retinopathy, Myopia
OCTA Metrics Repeatability and Reproducibility in Different Disorders
Retinal imaging is a corner stone in diagnosis of most retinal disorders. Standard imaging techniques e.g. fluorescein angiography and color fundus photography have a lot of limitations including limited resolution, invasive…
- Conditions
- Diabetic Retinopathy, Myopia, Choroidal Neovascularization, Healthy
- Trial name
- NCT04488887
- Testing
- Optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution, High-speed Multimodal Ophthalmic Imaging
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IMA-MODE (NCT04129021)
- Testing
- High-resolution retinal imaging through adaptive optics, High-resolution retinal imaging through holographic systems
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Trachoma, Chlamydia Trachomatis
Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger
Trachoma is a disease of poverty, which in the hyperendemic areas affects all individuals by the time they are two years old. Active disease is concentrated in children and occurs sporadically in adults.
- Trial name
- NCT00618449
- Testing
- Azithromcyin, Azithromycin
- Where
- 2 sites in United States, Niger
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Parkinson's Disease (PD), Parkinsonism
Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)
This study is designed to determine if magnetic resonance imaging (MRI) measures can be used to diagnose and monitor the progression of Parkinson's disease (PD) while distinguishing between PD and parkinsonisms [conditions that…
- Conditions
- Parkinson's Disease (PD), Parkinsonism, Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA)
- Trial name
- NCT01888185
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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