Clinical trials: Ophthalmic Disorders
Diabetic Retinopathy
Prevention of Onset and Transition to an Advanced Form of Diabetic Retinopathy in Children
The primary goal of the project is to create a normative database from data collected from a healthy pediatric population. A secondary aim is to compare normative data with data from pediatric patients with pre-existing type 1…
- Trial name
- NCT05615740
- Testing
- Optical coherence tomography (OCTA)
- Where
- Czechia
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University Hospital Ostrava
Exfoliation Syndrome
Central Corneal Thickness in Glaucoma
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate…
- Trial name
- NCT01023997
- Where
- Greece
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Open Angle Glaucoma, Ocular Hypertension
A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension
This is a Phase I/II stage to investigate the safety, tolerability, and ocular hypotensive efficacy of TO-O-1001 in healthy volunteers and patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT05456724
- Testing
- TO-O-1001
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Theratocular Biotek Co.
Dry Eye Syndrome
A Prospective Clinical Study Assessing the Effects of Tetracycline Antibiotic on Tear Film and Tear Lipid Composition Within a Population of Patients Diagnosed With Blepharitis and Dry Eye Disease
The purpose of this research project is to determine the effects of oral tetracycline such as Minocycline (Minocin) on tear film composition and tear lipid (meibomian gland secretions) characteristics in patients with chronic…
- Trial name
- NCT00355459
- Testing
- Tetracycline: Doxycycline analog
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Acne Vulgaris
Dry Eye Disease With Isotretinoin ISOTRETINOIN
The study aims to explore the effects of isotretinoin therapy on the dry eye parameters in acne vulgaris patients \& determine if it is dose-dependent or not.
- Trial name
- NCT06725290
- Testing
- Ocular Surface Disease Index (OSDI) questionnaire
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Glaucoma Open-Angle Primary, Ocular Hypertension
Open-Label Study of Safety of H1337 in Healthy Volunteers
The trial will evaluate the safety of one dose regimen of H-1337 [1% twice daily (b.i.d.)] in both eyes in healthy volunteers.
- Trial name
- NCT06572397
- Testing
- H-1337 1.0%
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- D. Western Therapeutics Institute, Inc.
Dry Eye Disease
Ditefossol Sodium 3% Eye Drops in Patients With Dry Eye
This study aimed to evaluate the efficacy of 3% diquafosol sodium eye drops in treating dry eye disease (DED) across different age groups using a propensity score-matched longitudinal design.
- Trial name
- NCT06560580
- Testing
- 3% Diquafosol Sodium Eye Drops
- Where
- China
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Glaucoma
Perimetric Testing With Virtual Reality
Perimetry is an essential component in the diagnosis and monitoring of glaucoma. Since the advent of Standard Automated Perimetry (SAP), one of the clinical standards has been the Humphrey Field Analyzer (HFA, Carl Zeiss AG…
- Trial name
- NCT06549010
- Testing
- Perimetric test
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Envision Health Technologies, Inc.
Retinopathy of Prematurity, Myopia
Prematurity and Ophthalmological Changes
Ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity
- Trial name
- NCT06452524
- Testing
- axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Cornea
Influence of Silicone Hydrogel Extended Contact Lens Wear on Corneal Sensitivity
Soft contact lens wear reduces the amount of oxygen reaching the eye, which may have an influence on corneal sensitivity. The aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline…
- Trial name
- NCT05298917
- Testing
- silicone hydrogel contact lens
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Uveitis
Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients
Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune.
- Trial name
- NCT06070935
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Assiut University
Corneal Neovascularization, Neutrophils
Correlation Between a Novel Subset of Neutrophil and Corneal Neovascularization.
The purpose of this study is to determine whether a novel subset of neutrophils is correlated with corneal neovascularization in the patients suffered from ocular chemical injury.
- Trial name
- NCT05659940
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Periodontitis, Dry Eye Disease (DED)
Association Between Periodontitis and Dry Eye Disease: A Cross-Sectional Study
This study is aiming at exploring the association between periodontitis and dry eye disease, which are both chronic inflammatory diseases that might have common pathogenic mechanisms.
- Trial name
- NCT07873697
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Open Angle Glaucoma
Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost
A randomized, multi-site, parallel-group, prospective study of patients who are adults with a diagnosis of mild to moderate open-angle glaucoma (OAG), currently on an on-label use of combination topical medication of Cosopt and…
- Trial name
- NCT06883123
- Testing
- Simbrinza 0.2%-1% Ophthalmic Suspension, Rocklatan 0.02%-0.005% Ophthalmic Solution, Cosopt PF 2%-0.5% Ophthalmic Solution
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Prairie Eye Center
Refractive Error
Clinical Investigation on Assessing the Repeatability and Reproducibility of Central and Peripheral Refractive Error
This is a unilateral, non-interventional study. Each subject will be unilaterally measured with the WAM-5500 autorefractor by 3 testers. All measurements will be made on the right eye only.
- Trial name
- NCT06209476
- Testing
- Experimental
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Diabetic Retinopathy
Automated AI-based System for Early Diagnosis of Diabetic Retinopathy
In this pivotal trial, we aim to perform a prospective study to find the efficacy of iPredict, an artificial intelligence (AI) based software tool on early diagnosis of Diabetic Retinopathy (DR)in the primary care, optometrist…
- Trial name
- NCT05324189
- Testing
- Referable versus Non Referable Diabetic Retinopathy diagnostic test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Amblyopia
Early Detection and Prevention of Amblyopia and Visual Impairment Through Systematic Pediatric Vision Screening
Amblyopia, characterized by reduced visual acuity, develops in childhood due to insufficient sensory stimulation of the affected eye.
- Trial name
- FALSSE (NCT07112560)
- Testing
- Standard screening procedure for amblyopia, New amblyopia screening method using a virtual reality headset.
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Diabetic Retinopathy, Type 2 Diabetes
Enriched Eggs for Retina Health in Type 2 Diabetes
Diabetes mellitus has been declared a major public health issue. Among the complications of the disease, retinopathy can have a significant impact on mobility and quality of life for individuals living with diabetes.
- Trial name
- NCT04496817
- Testing
- Docosahexaenoic Acid and Lutein Enriched Eggs, Regular Eggs
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Acne
Sunscreen Efficacy Against the Reccurence of Lesions Post-sun Exposure in Acneic Subjects
The aim of this study is firstly to assess the tolerance of the sunscreen RV4857A-CD2110 after 28 days and 57 days of at least a twice daily on the study areas, secondly to assess anti-imperfection efficacy after 28 days and 57…
- Trial name
- NCT05168397
- Testing
- RV4857A
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
Cornea
Evaluation of the Accuracy of Corneal Epithelial Thickness Mapping With SD-OCT
Evaluate the accuracy of the RTVue-XR and iVue for measuring the total corneal thickness, the epithelial thickness, and the stromal thickness in normal subjects and patients with various corneal conditions.
- Trial name
- NCT02775097
- Testing
- OCT
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Optovue
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