Clinical trials: Ophthalmic Solutions
Dry Eye Disease
Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm
The purpose of this study is to evaluate the preliminary safety and effectiveness of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops in the treatment of dry eye diseases post refractive surgery…
- Trial name
- NCT05738629
- Testing
- Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neurotrophic Keratitis
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Neurotrophic Keratitis Subjects
This study will enroll subjects with stage 2 or 3 neurotrophic keratitis. Subjects will be randomized in a 1:1 ratio to the CSB-001 investigational treatment arm or vehicle control arm.
- Trial name
- NCT04909450
- Testing
- CSB-001 Ophthalmic Solution 0.1%, Vehicle Control
- Where
- 48 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Claris Biotherapeutics, Inc.
Normal Volunteers
Formulation Comparison in Normal Volunteers
This is a double-masked, single-center, crossover study in which normal volunteers will be randomized to receive one of two formulations of 0.5% AR-12286 Ophthalmic Solution for 8 days.
- Trial name
- NCT01250197
- Testing
- AR-12286
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aerie Pharmaceuticals
Healthy Volunteers
Safety and Tolerability of NTX-101 in Korean Healthy Volunteers
A double-blinded, placebo controlled, multiple dose, randomized, single site, phase 1 clinical trial to evaluate safety, tolerability, and pharmacokinetics of NTX-101 topical eye drop in Korean healthy volunteers
- Trial name
- NCT05041543
- Testing
- NTX-101
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pinotbio, Inc.
Blepharitis
A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Vehicle in Subjects With Blepharitis (P08636)
The purpose of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus vehicle over a four-week treatment period in treating the signs and symptoms of subjects with blepharitis and to…
- Trial name
- NCT01269658
- Testing
- Azithromycin ophthalmic solution, 1%, Vehicle
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
Open Angle Glaucoma or Ocular Hypertension
OPC-1085EL in the Treatment of Primary Open Angle Glaucoma or Ocular Hypertension in Chinese Subjects
It is a phase III, multi-center, randomized, single-blind (to evaluator), parallel, and positive-controlled clinical trial evaluating the efficacy and safety of OPC-1085EL in the treatment of primary open angle glaucoma or ocular…
- Trial name
- NCT05583474
- Testing
- OPC-1085EL, 0.005% Latanoprost
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Otsuka Beijing Research Institute
Diabetic Macular Edema (DME), Pars Plana Vitrectomy
SAR 1118 in Human Subjects Undergoing Pars Plana Vitrectomy
The purpose of this study is to determine the safety, tolerability, and pharmacokinetics of SAR 1118 within the anterior and posterior chamber of the eye and plasma in subjects undergoing elective vitrectomy when treated with…
- Trial name
- NCT00936520
- Testing
- SAR 1118 0.1%, SAR 1118 1.0%, SAR 1118 5.0%
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Contact Lens Fit, Myopia
Clinical Performance of a Silicone Hydrogel Lens With Use of FID 114675A
The purpose of this study is to evaluate the clinical performance of a silicone hydrogel contact lens when used with an investigational multi-purpose disinfecting solution (MPDS).
- Trial name
- NCT01240135
- Testing
- FID 114675A multi-purpose disinfecting solution (MPDS), renu fresh Multi-Purpose Solution (MPS), Galyfilcon A contact lenses (Acuvue Advance)
- Volunteers
- 89 people
- Sponsor
- Alcon Research
Dry Eye Syndromes
Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms
The purpose of this study is to evaluate and compare the effects of Altaire Gel forming solution and Refresh Tears in mild-moderate dry eye patients.
- Trial name
- NCT01382810
- Testing
- Altaire Gel forming solution, Refresh Tears
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Outcomes of Cyclosporine Eye Drops in Herpetic Keratitis
Clinical Outcomes of Cyclosporine Eye Drops in Management of Herpetic Keratitis
Objective: To compare the additive effect of topical cyclosporine A 0.05% eye drops to prednisolone eye drops, with topical prednisolone acetate 1% eye drops alone in treatment of herpetic stromal keratitis.
- Trial name
- NCT05720715
- Testing
- cyclosporine A 0.05% eye drops
- Where
- Kuwait
- Volunteers
- 30 people
- Sponsor
- Farwaniya Hospital
Glaucoma
A Study to Evaluate Efficacy and Safety Effects Using Mikelan® LA Ophthalmic Solution (OS) 2% Versus Timoptol® XE Ophthalmic Solution (OS) 0.5% in Ocular Hypertension Patients
The primary objective of the clinical study is to evaluate the efficacy and safety for Mikelan LA eye drops 2% (once per day) of intra-ocular pressure decreased.
- Trial name
- NCT00972426
- Testing
- carteolol (Mikelan), timolol (Timoptol), latanoprost (Xalatan)
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Taiwan Otsuka Pharm. Co., Ltd
Allergic Conjunctivitis
AL-38583 Ophthalmic Solution for Allergic Conjunctivitis Associated Inflammation
The purpose of this study is to assess the safety and efficacy of AL-38583 in the treatment of the signs of inflammation associated with allergic conjunctivitis.
- Trial name
- NCT01001091
- Testing
- AL-38583 ophthalmic solution, AL-38583 ophthalmic solution vehicle, Dexamethasone ophthalmic suspension, 0.1%
- Volunteers
- 312 people
- Sponsor
- Alcon Research
Conjunctivitis, Allergic
Safety and Efficacy of Lastacaft® for the Prevention of Itching Associated With Allergic Conjunctivitis in Korea
This post-marketing surveillance study will assess the safety and efficacy of Lastacaft® Opthalmic Solution 0.25% (Alcaftadine) for the prevention of itching associated with Allergic Conjunctivitis as prescribed as standard of…
- Trial name
- NCT02555761
- Testing
- Alcaftadine Ophthalmic Solution 0.25%
- Where
- 81 sites in South Korea
- Volunteers
- 3,423 people
- Sponsor
- Allergan
Keratoconjunctivitis Sicca
Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye
Comparative efficacy trial of INS365 Ophthalmic Solution and placebo in patients with dry eye.
- Trial name
- NCT00037661
- Testing
- INS365 Ophthalmic Solution
- Volunteers
- 222 people
- Sponsor
- Merck Sharp & Dohme LLC
Open-Angle Glaucoma, Ocular Hypertension
Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution
The purpose of this study is to evaluate AZORGA® Ophthalmic Suspension compared to COSOPT® Ophthalmic Solution for IOP-lowering efficacy in subjects with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT02325518
- Testing
- Brinzolamide 1%/Timolol maleate 0.5% fixed combination ophthalmic suspension, Dorzolamide hydrochloride 1%/Timolol maleate 0.5% ophthalmic solution, Subject's habitual PGA monotherapy
- Where
- Japan
- Volunteers
- 218 people
- Sponsor
- Alcon, a Novartis Company
Myopia
Myopia Control With Novel Eye Drops
Myopia currently affects 30% of the world and by 2050, almost 50% of the world will be myopic based on conservative estimates.1 In 2050, this will equate to almost 5 billion people with myopia, and those with high myopia will…
- Trial name
- NCT04301323
- Testing
- BHVI1 eye drops, BHVI2 eye drops, BHVI3 eye drops
- Where
- Vietnam
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hai Yen Eye Care
Neurotrophic Keratopathy
An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops
A prospective, longitudinal, cross-sectional, observational Study with a 8-week Follow-up to evaluate the renewal of corneal nerves structure and function in patients with Neurotrophic Keratopathy treated with recombinant human…
- Trial name
- NCT04293549
- Testing
- Cenegermin, recombinant human Nerve Growth Factor (rhNGF) eyedrops
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Glaucoma, Ocular Hypertension
Safety and Efficacy of Different Formulations of Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
This study will evaluate the safety and efficacy of bimatoprost 0.03% formulation B ophthalmic solution with LUMIGAN® (bimatoprost ophthalmic solution 0.03%) once daily for 12 weeks in patients with glaucoma or ocular hypertension
- Trial name
- NCT01099774
- Testing
- Bimatoprost 0.03% Formulation B Ophthalmic Solution, Bimatoprost 0.03% Ophthalmic Solution
- Where
- United States
- Volunteers
- 597 people
- Sponsor
- Allergan
Dry Eye Syndromes
HU007 Eye Drops in Patients With Dry Eye Syndrome
This study is a multicenter, randomized, double blind, Restasis-controlled non-inferiority, Phase III Study to evaluate the efficacy and safety of HU007 eye drops in patients With dry eye syndrome
- Trial name
- NCT04384991
- Testing
- HU007, Restasis eye drop
- Where
- South Korea
- Volunteers
- 216 people
- Sponsor
- Huons Co., Ltd.
Dry Eye
Evaluation of SYSTANE Ultra Lubricant Eye Drops
To evaluate the safety and efficacy of two artificial tears in dry eye patients.
- Trial name
- NCT00702377
- Testing
- SYSTANE Ultra, Optive
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Alcon Research
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