Clinical trials: Opioid
Efficacy of Dextromethorphan, Morphine Consumption
Efficacy of Pre- and Post-Operative Oral Dextromethorphan
We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy.
- Conditions
- Efficacy of Dextromethorphan, Morphine Consumption, Pain
- Trial name
- NCT00199303
- Testing
- pre-operatively followed by 30 mg three times per day after surgery
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Shoulder Pain, Postoperative Pain
Suprascapular Nerve Block Efficacy for Shoulder Surgery
This study evaluates the analgesia induced by suprascapular nerve block in comparison to interscalene nerve block in arthroscopic rotator cuff repairs.
- Conditions
- Shoulder Pain, Postoperative Pain, Rotator Cuff Tears, Anesthesia
- Trial name
- NCT04364542
- Testing
- Suprascapular nerve block, Interscalene Nerve Block, Arthroscopic rotator cuff repair
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Ivan Simionato
Substance-Related Disorders
Resonance Breathing Intervention Opioid Use Disorder
This study aims to assess the feasibility of an intervention for the management of craving, stress, anxiety, and depression among people who use opioids via a resonance breathing smartphone app.
- Trial name
- NCT05830773
- Testing
- Resonance Breathing Exercises
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Percutaneous Nephrolithotomy (PCNL), Nephrolithiasis
Erector Spinae Plane Block for Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is an effective standard urological procedure for the fragmentation and removal of large renal calculi.
- Conditions
- Percutaneous Nephrolithotomy (PCNL), Nephrolithiasis, Renal Calculi
- Trial name
- NCT07457983
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fadime Tosun
Aging, Fall Injury
Medication Empowerment and Deprescription for Safety (MEDS) Study
The long-term goal of this pragmatic, cluster randomized study is to develop a sustainable program for healthcare systems to reduce fatal and nonfatal falls among high-risk older adults living independently in their communities.
- Trial name
- MEDS (NCT04612166)
- Testing
- Medication Action Plan and Patient Empowerment (MAP-PE )
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Iowa
Analgesia, Cancer, Breast
Serratus Plane Block Versus Serratus Plane Block Plus Parasternal Block Combination for Breast Surgery
Mastectomy is a technique often used in breast cancer surgery. Patients experience moderate to severe pain postoperatively after this procedure.
- Trial name
- NCT05911373
- Testing
- group serratus plan block, group serratus and parasternal plan block
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ataturk University
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Opioid Use, Opioid Use Disorder
Enhancing Prospective Thinking in Early Recovery (PARK)
The goal of this clinical trial is to demonstrate the commercial potential for a novel virtual reality (VR) intervention in preparation for Phase II development.
- Conditions
- Opioid Use, Opioid Use Disorder, Substance Use Disorders
- Trial name
- PARK (NCT05908097)
- Testing
- Virtual Reality Avatar Intervention, Virtual Reality Empty Park
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- Indiana University
Postoperative Pain, Cardiac Surgery
Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is often associated with significant postoperative pain. Poor pain control after sternotomy may increase opioid use, delay mobilization, prolong extubation time, and…
- Conditions
- Postoperative Pain, Cardiac Surgery, Postoperative Pain After Cardiac Surgery Via Median Sternotomy
- Trial name
- SPARE-CABG (NCT07498946)
- Testing
- Thoracic paravertebral block (TPVB), Bilateral Deep Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Opioid Use, Pain, Postoperative
Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section
Postpartum patients delivered by cesarean section will be randomized to NSAIDS Vs NSAIDS plus opioid
- Trial name
- IVY (NCT03372382)
- Testing
- Ibuprofen, Acetaminophen, Norco
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid Use Disorder, Neonatal Abstinence Syndrome
An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)
The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies to provide evidence-based OUD…
- Trial name
- SUPPORT (NCT06576323)
- Testing
- An implementation model for co-located Medications for Opioid Use Disorder (MOUD) prescription in the NICU
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cannabis-Related Disorder, Cannabis Abuse
Implementing Screening for Cannabis and Other Drug Use Disorders in Primary Care: Impact on Diagnosis and Treatment
Our proposed evaluation study is designed to evaluate the impact of a recently completed stepped wedge cluster randomized trial, conducted at Kaiser Permanente Washington (KPWA), of an intervention to improve care and management…
- Conditions
- Cannabis-Related Disorder, Cannabis Abuse, Drug Abuse, Drug Use Disorders
- Trial name
- NCT06249542
- Testing
- Care Delivery Improvement Intervention
- Volunteers
- 363,936 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601480)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- University of Minnesota
Alcohol Use Disorder, Opioid Use Disorder
Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Opioid Use
This project aims to improve the health of individuals engaged in co-occurring alcohol and opioid use by supporting the maintenance of behavior change initiated in substance use treatment.
- Trial name
- NCT05325788
- Testing
- e-Covery, Comparator Condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Pain, Chronic, Opioid Use
Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use
This is a single site, two-arm, parallel group randomized clinical trial comparing the effect of two mindfulness-based interventions (Mindful Interoceptive Mapping vs.
- Trial name
- NCT04523766
- Testing
- Mindfulness of Breath, Mindful Interoceptive Mapping
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- University of Utah
Opioid-use Disorder
Extended-Release Buprenorphine vs. Sublingual Buprenorphine for the Treatment of Opioid Use Disorder
The study is 12-week, randomized, open-label study comparing injectable extended-release buprenorphine (Sublocade) to standard therapy (sublingual buprenorphine), to see if Sublocade will be more helpful in treating opiate use…
- Trial name
- NCT04352166
- Testing
- extended-release buprenorphine (BXR), sublingual buprenorphine (BSL)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Frances R Levin
Opioid Misuse
Decreasing Opioid Misuse and Habit-forming Behaviors Following Prescription in Patients Undergoing Cesarean Section
Background: Cesarean delivery is one of the most common obstetric procedures experienced among women who are pregnant.1 Women with Cesarean deliveries have a higher rate of peripartum opioid prescriptions and persistent opioid…
- Trial name
- NCT05461196
- Testing
- CPMRx
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jessica Morgan
Opioid Users
Abuse Potential Study of PF-00345439
This study will determine the relative abuse potential of intact and chewed PF-00345439 (Oxycodone Extended-Release Capsules) compared to crushed oxycodone HCL immediate release (IR) tablets and placebo administered orally to…
- Trial name
- NCT01986283
- Testing
- Capsule, PF-00345439, oxycodone
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Obesity, Postoperative Pain
Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy
Opioid free anesthesia is an anesthetic technique, in which administration of multimodal analgesia and sympathicolytics provides hemodynamic stability without use of opioids.
- Conditions
- Obesity, Postoperative Pain, Postoperative Nausea, Postoperative Vomiting
- Trial name
- NCT04260659
- Testing
- Dexmedetomidine Hydrochloride [Dexdor], Remifentanil [Ultiva], Ketamine [Ketalar]
- Where
- Poland
- Volunteers
- 59 people
- Sponsor
- Medical University of Warsaw
Substance Abuse
A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure
The trial comprises an Enrollment Visit, a Qualification Phase, a Treatment Phase (including 3 treatment periods), a Final Examination, and a Follow-up Phone Call.
- Trial name
- NCT03765346
- Testing
- Oxycodone IR ADF, Oxycodone API powder
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH