Clinical trials: Opioid-Related Disorders
Opioid-use Disorder, Pregnancy Related
Quantitative Sensory Psychophysical Correlates of Pain in Pregnant Women With OUD
This is a prospective observational case-control study comparing quantitative sensory testing data preformed during the third trimester of pregnancy and within 24 hours postpartum in women on medication-assisted treatment for…
- Trial name
- Q-PRONTO (NCT04888962)
- Testing
- OUD
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Abuse
Effects of Pioglitazone, a PPARgamma Receptor Agonist, on the Abuse Liability of Oxycodone
The ability of pioglitazone (PIO) to alter the effects of opioids in humans has not been characterized in a controlled laboratory setting.
- Trial name
- NCT01395784
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Alcohol Use Disorder
COVID-19-Related Opioid Treatment Policy Evaluation
Our nation is facing the COVID-19 pandemic during an ongoing opioid epidemic. Effective treatment for patients with opioid use problems involves a treatment method called Medication-Assisted Treatment, or MAT.
- Trial name
- COPE (NCT05028998)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
Opioid-use Disorder
Evaluating Adaptive Dispenser Initiation Protocols for MySafeRx During Post-detox Buprenorphine Treatment- a Pilot Study
Opioid overdoses are a significant problem nationwide and novel interventions that can prevent overdose by improving buprenorphine treatment for opioid use disorder are a public health priority.
- Trial name
- NCT04449744
- Testing
- MySafeRx Inspire Plus, MySafeRx Inspire Flex
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Opioid Use Disorder
A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.
This is a Phase 1, single-centre, randomized, double-blind, placebo-controlled, 2 fixed sequences, multiple dose study in healthy male and/or female recreational opioid users.
- Trial name
- NCT05587998
- Testing
- Morphine, AZD4041
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused when they are crushed and snorted.
- Trial name
- NCT01775189
- Testing
- crushed ALO-02 30 mg/3.6 mg, crushed oxycodone IR 30 mg
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer
Opioid-related Disorders
BUPrenorphine Facilitated Access and Supportive Treatment --AIM 3
The goal of this study is to test whether peer mentors (i.e., individuals with past opioid addiction and prior incarceration) can facilitate entrance into buprenorphine (Suboxone) treatment for individuals with opioid use…
- Trial name
- BUPFAST (NCT02902835)
- Testing
- BUP_FAST, Referral to treatment
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Opioid Use, Constipation
Reflexology Socks and Opioid-induced Constipation
Opioids are one of the most commonly used treatment approaches in the treatment of severe pain due to cancer and non-cancer causes. The most commonly reported side effect by patients related to opioid use is constipation.
- Conditions
- Opioid Use, Constipation, Reflexology
- Trial name
- NCT05314335
- Testing
- Reflexology socks+walking, Just walking
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Anxiety, Opioid Consumption
Associations Between Analgesia Nociception Index and Preoperative Anxiety
The management and prediction of pain is one of the most crucial jobs for anesthetists. It has been shown that a patient's ability to remain calm during stressful situations is related to their post-surgical pain scores.
- Conditions
- Anxiety, Opioid Consumption, Cesarean Section
- Trial name
- PANIC (NCT04875572)
- Testing
- Analgesia Nociception Index (ANI) Monitor
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Opioid-Related Disorders, Substance-Related Disorders
Role of Instructions in Nitrous Oxide Effects and Choice - 10
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000258
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Neonatal Abstinence Syndrome
Actigraphy and Neonatal Abstinence Syndrome of Hospitalized Newborn in Intensive Care Units
The aim of this study is to analyse the correlation between actigraphy and Lipsitz scoring system in neonatal opioid abstinence syndrome of hospitalized newborn in intensive care units
- Trial name
- ACTINEO2 (NCT04983563)
- Testing
- Actigraphy, eTact
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Opioid-use Disorder
Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
The primary objective of this pilot study is to program an opioid use disorder (OUD) clinical decision support (CDS) tool for use in an electronic medical record (EMR) and obtain high primary care physician (PCP) usability and…
- Trial name
- COMPUTE (NCT03559179)
- Testing
- Opioid Wizard
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Opioid Use Disorder
Autobiographical Memory in Opioid Use Disorder
The research study is being conducted to better understand memory function in people with opioid use disorder (OUD) and whether memory training can improve the symptoms and lives of people with OUD.
- Trial name
- NAMO (NCT06643988)
- Testing
- MemFlex
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Post-traumatic Stress Disorder (PTSD), Trauma
Kappa Opioid Receptor Imaging in Post-traumatic Stress Disorder (PTSD)
This study uses positron emission tomography (PET) imaging to measure kappa opioid receptors (KOR) in the brains of individuals with and without post-traumatic stress disorder (PTSD).
- Trial name
- NCT02237703
- Testing
- Positron emission tomography (PET) imaging
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid-Related Disorders
Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users
To determine the relative abuse potential of VYCAVERT (hydrocodone bitartrate and acetaminophen) compared to GENERIC H/A (hydrocodone bitartrate and acetaminophen) when crushed and administered intranasally to non dependent…
- Trial name
- NCT01759446
- Testing
- Generic H/A taken first, Vycavert taken first, Generic H/A plus i taken first
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
Opioid Misuse
A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin.
- Trial name
- NCT04941950
- Testing
- PlaySmart, Video Game Control
- Where
- 15 sites in United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Tyra Boomer
Pain, Chronic, Prescription Drug Abuse (Not Dependent)
Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain
Genetic variability from epigenetic modification of genes related to pain physiology and opioid pharmacodynamics may influence susceptibility to high-impact chronic musculoskeletal pain, opioid efficacy, and vulnerability to…
- Trial name
- LEAP (NCT03947749)
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sleep Disorder; Breathing-Related, Pain
Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids
Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB).
- Conditions
- Sleep Disorder; Breathing-Related, Pain, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- PRESTO (NCT04928157)
- Testing
- Positive Airway Pressure (PAP)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Opioid-use Disorder, Opioid Dependence
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
HOMER is a national study comparing three methods of induction for Medication Assisted Treatment (MAT) for Opioid Use Disorder (OUD); home versus office versus telehealth-based inductions.
- Trial name
- HOMER (NCT04664062)
- Testing
- Medication Assisted Treatment
- Where
- 2 sites in United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid Use, Opioid Dependence
Efficiency And Quality In Post-Surgical Pain Therapy After Discharge
Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy.
- Conditions
- Opioid Use, Opioid Dependence, Opioid Misuse, Post-Surgical Complication
- Trial name
- EQUIPPED (NCT05221866)
- Testing
- Empowering Patient to Steer Their Pain Management After Surgery, Provider-facing Prescription Aid
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Nebraska