Clinical trials: Oral
Diarrhea
Shigella WRSS1 Vaccine Trial in Bangladesh
This is a research study of an experimental (investigational) live attenuated Shigella sonnei vaccine (WRSS1) to find a dose of the vaccine that is safe, tolerable, and develops an immune response.
- Trial name
- NCT02934178
- Testing
- Shigella sonnei Strain WRSS1 Vaccine
- Where
- Bangladesh
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PATH
Oral Mucositis
Mulberry Syrup on Oral Mucositis Healing
Objective: This study was carried out to investigate the effectiveness of oral care with black mulberry syrup on oral mucositis healing in individuals with COPD.
- Trial name
- NCT04118335
- Testing
- Black Mulberry Syrup
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- TC Erciyes University
Healthy
Pharmacodynamics, Safety and Pharmacokinetics After Oral Administration of BIBR 1048 MS in Healthy Volunteers
The objective of this study was to assess safety, pharmacokinetics and the effect of BIBR 953 ZW on coagulation parameters of BIBR 953 ZW after oral single doses of the prodrug, BIBR 1048 MS, in healthy male subjects.
- Trial name
- NCT02170116
- Testing
- BIBR 1048 MS dose 1, BIBR 1048 MS dose 2, BIBR 1048 MS dose 3
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
White Spot Lesions, Dental Plaque
AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of artificial intelligence-generated WhatsApp reminders on improving oral hygiene practices among individuals aged 20-40 years visiting the periodontal clinic at…
- Conditions
- White Spot Lesions, Dental Plaque, Oral Hygiene, Oral Health
- Trial name
- NCT06897033
- Testing
- Health education followed by AI-generated Whatsapp reminders, Oral Health Education
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
A Study of Rifabutin and MK-4646 in Healthy Participants (MK-4646-004)
Researchers have designed a new study medicine called MK-4646 as a new way to treat human immunodeficiency virus (HIV). Rifabutin is a medication used to treat tuberculosis (TB).
- Trial name
- NCT07199452
- Testing
- MK-4646, Rifabutin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Gingivitis
Evaluation of the Effect of the Toothpaste on Delicate Gums
The goal of this study is to learn if a toothpaste works to alleviate gingivitis in adults. It will also learn about the safety of the product.
- Trial name
- NCT07494747
- Testing
- Gingivitis toothpaste, Regular toothpaste
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Lacer S.A.
Healthy
Bioequivalence Study of Ropinirole Hydrochloride ER Tablets 2 mg Under Fed Condition
This is an open label, randomised, balanced, two-treatment, two-period, two-sequence, crossover, oral bioequivalence study.
- Trial name
- NCT01627847
- Testing
- Ropinirole
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Oral Ulcer
Therapeutic Effect of Folic Acid in Healing of Oral Ulcers
patients reporting at the department of oral medicine with the complain of oral ulceration will be asked to participate in this study.
- Trial name
- NCT04989049
- Testing
- Folic Acid 5 MG
- Volunteers
- 75 people
- Sponsor
- Dow University of Health Sciences
Oral Bacterial Colonization, Oral Hygiene
Effects of Three Oral Hygiene Protocols on Oral Bacteria in Intensive Care Patients
Patients in intensive care may develop changes in the bacteria found in their mouths. Some of these bacteria can cause infections, and patients who cannot clean their own teeth depend on staff to provide oral care.
- Trial name
- NCT07868549
- Testing
- Mechanical Oral Hygiene, Chlorhexidine, Hexetidine
- Where
- Croatia
- Volunteers
- 86 people
- Sponsor
- University of Zagreb
Gingival Recession
Amnion Membrane Versus DFGG Using the Tunneling Technique in Management of Gingival Recession Defects.
Treatment of gingival recession is indicated mainly for esthetic reasons and keratinized tissue augmentation (Zucchelli and Mounssif, 2015).
- Trial name
- NCT06146855
- Testing
- Tunneling procedure with Amnion Membrane, Tunneling procedure with De-epithelialized Free Gingival Graft
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anemia of Chronic Kidney Disease
Effect of Adding Lactoferrin on Oral Iron on Anemia in Chronic Kidney Disease Patients
The aim of this study is to evaluate the effects of adding lactoferrin to the every-other-day oral iron supplementation in iron deficiency anemia and chronic kidney disease patients.
- Trial name
- NCT05900635
- Testing
- Lactoferrin, Ferrous Glycine Sulfate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Bowel Preparation
A Study Comparing the Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution With PREPOPIK® for Colon Cleansing in Preparation for Colonoscopy
The purpose of this study is to compare the Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution with PREPOPIK® for colon cleansing in adult subjects undergoing colonoscopy.
- Trial name
- NCT03017235
- Testing
- Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution, Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Powder
- Where
- 14 sites in United States, Canada
- Volunteers
- 917 people
- Sponsor
- Ferring Pharmaceuticals
Multiple Myeloma
An Expanded Treatment Protocol of Panobinostat in Combination Therapy for Relapsed, and Relapsed and Refractory Multiple Myeloma
The purpose of this study is to provide oral panobinostat (PAN) treatment to relapsed or relapsed and refractory multiple myeloma patients who are without satisfactory treatment alternatives prior to the commercial availability*…
- Trial name
- NCT02568943
- Testing
- Panobinostat
- Where
- 40 sites in Austria, Canada and 4 more
- Sponsor
- Novartis Pharmaceuticals
Cervical Cancer, Esophageal Cancer
Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of isotretinoin may be an effective way to prevent cancer or stop cancer from growing.
- Conditions
- Cervical Cancer, Esophageal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00002506
- Testing
- recombinant interferon alfa, isotretinoin
- Where
- 6 sites in United States
- Sponsor
- Hoag Memorial Hospital Presbyterian
Dental Malocclusion
Evaluation of the Effect of Corticotomy and Low Level Laser Therapy on Orthodontic Tooth Movement
The aim of the present study was to compare, a standard efficient technique in accelerating OTM as surgical corticotomy as a gold standard versus surgical corticotomy combined with LLLT in an attempt for further acceleration of…
- Trial name
- NCT03906084
- Testing
- Corticotomy and low laser therapy, Corticotomy facilitated Orthodontics
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lung Cancer
Vinorelbine in Treating Older Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of vinorelbine taken by mouth in treating older patients…
- Trial name
- NCT00008333
- Testing
- vinorelbine tartrate
- Where
- 13 sites in United States
- Volunteers
- 59 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Healthy
A Safety Study of ARRY-371797 in Healthy Subjects
This is a Phase 1 study, involving both 1-day and 8-day dosing periods, designed to test the safety of investigational study drug ARRY-371797 in healthy subjects.
- Trial name
- NCT00790049
- Testing
- ARRY-371797, p38 inhibitor; oral
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Array Biopharma, now a wholly owned subsidiary of Pfizer
Digestive Cancer
A Trial Assessing Several Schedules of Oral S-1 in Combination With a Fixed Dose of Oxaliplatin and Irinotecan
This study is to determine the Maximal Tolerated Dose (MTD), the Dose Limitant Toxicities (DLTs) and the safety profile of S-1 combined with fixed doses of Irinotecan (SIRI schedule) and fixed doses of Irinotecan and Oxaliplatin…
- Trial name
- SIRINOX (NCT02387138)
- Testing
- S-1, Irinotecan, Oxaliplatin
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Oral Lichen Planus
The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP).
- Trial name
- NCT06932848
- Testing
- Curcumin in Nanogels, 0.1% Fluocinolone Acetonide Oral Paste
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Healthy Volunteer
A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO5545965 in Healthy Volunteers
This single-center, randomized, investigator/subject-blind, adaptive multiple ascending-dose, placebo-controlled study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of RO5545965 in healthy…
- Trial name
- NCT01864226
- Testing
- RO5545965
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche