Clinical trials: Oral Cancers
Dysplasia, Lip and Oral Cavity Carcinoma
Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders
This early phase I trial studies how well multimodal imaging works for surveillance in patients with oral potentially malignant disorders.
- Conditions
- Dysplasia, Lip and Oral Cavity Carcinoma, Oral Disorder, Premalignant Lesion
- Trial name
- NCT02790853
- Testing
- Biopsy, Fluorescence Imaging, High-Resolution Microendoscopy
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary
Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer
This phase II trial is studying how well giving carboplatin, paclitaxel, cetuximab, and erlotinib hydrochloride together works in treating patients with metastatic or recurrent squamous cell head and neck cancer.
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT01316757
- Testing
- cetuximab, paclitaxel, carboplatin
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Fox Chase Cancer Center
Basal Cell Carcinoma
Vismodegib for Treatment of Basal Cell Carcinoma
The primary objectives of this study are to assess, using Mohs micrographic surgery (MMS) at the end of treatment, the efficacy (primary) and safety (secondary) of vismodegib compared to placebo in the oral adjunctive pre…
- Trial name
- Erivedge (NCT01543581)
- Testing
- Vismodegib
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abel Torres, MD
Mandible Cyst, Mandible Tumor
Bone Lid Technique Versus Standard Technique for Treatment of Mandibular Lesions
Twenty patients with benign mandibular lesion will be included in this study. the patient will be divided randomly (10 patients each group). Group I the lesion will be treated using bone lid technique.
- Conditions
- Mandible Cyst, Mandible Tumor, Mandibular Diseases
- Trial name
- NCT05987930
- Testing
- bone lid technique, standard technique
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tanta University
Nonsquamous Nonsmall Cell Neoplasm of Lung
Evaluate the Safety and Efficacy of BLEX 404 Oral Liquid Combined With Pemetrexed + Cisplatin Therapy
Maitake is reported with immunomodulatory functions against tumor growth in terms of its unique molecular structure, β-glucan polysaccharides within 1, 6 main chain having 1, 3 branches and a 1, 3 main chain having 1, 6 branches…
- Trial name
- NCT05764928
- Testing
- BLEX 404
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rgene Corporation
Myofacial Pain Syndrome
Dry Needling and Low-Level Laser Microcurrent Electrical Stimulation for Myofascial Pain Syndrome
This study aims to evaluate the effectiveness of dry needling and Low-Level Laser Microcurrent Electrical Stimulation (LL MCES) in patients with acute upper trapezius myofascial pain syndrome (MPS) by assessing both biological…
- Trial name
- NCT07750392
- Testing
- Dry Needle, Low-Level Laser Microcurrent Electrical Stimulation
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Udayana University
Soft Tissue Sarcoma
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure
The purpose of this study is to assess efficacy and safety of LBH589 - Panobinostat®, a potent HDACi, in patients with advanced STS who experiment disease progression after or during first-line chemotherapy.
- Trial name
- ESTIM-LBH (NCT01136499)
- Testing
- LBH589 (Panobinostat®)
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Centre Leon Berard
Head and Neck Cancer, Oral Mucositis
An Exploratory Study on Optical Assessment of Oral Mucositis
Objectives: 1. To assess the tolerability of performing optical coherence tomography and/or optical spectroscopy in patients with acute oral mucositis. 2.
- Trial name
- NCT00488332
- Testing
- Optical Coherence Tomography, Fluorescence Spectroscopy, Pain Scale Questionnaire
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Myeloma
Study of Pomalidomide, Oral Dexamethasone and Ixazomib in Patients With Relapsed MM Who Have Received Lenalidomide
The purpose of this study is to evaluate the efficacy and safety of ixazomib, oral dexamethasone and in patients with relapsed multiple myeloma who have received lenalidomide.
- Trial name
- NCT04989140
- Testing
- Drug: Ixazomib Drug:pomalidomide Drug:dexamethasone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Oral Cavity Squamous Cell Carcinoma
Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer
This clinical trial studies how well helical computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and cone beam computed tomography (CBCT) work alone or in combination in predicting…
- Trial name
- NCT03053960
- Testing
- Computed Tomography, Positron Emission Tomography and Computed Tomography Scan, Cone-Beam Computed Tomography
- Volunteers
- 8 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Survivors of Childhood Cancer, Alopecia
A Study of Oral Minoxidil to Treat Hair Loss in Children, Teens, and Young Adults Who Are Cancer Survivors
This study will test whether minoxidil taken by mouth (oral minoxidil) can improve hair loss caused by cancer treatment in children and young adults.
- Trial name
- NCT05778825
- Testing
- Oral Minoxidil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Cancer, Xerostomia
Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia
PRIMARY AIM 1. Determine the feasibility of providing true and sham acupuncture treatment to patients at Fudan University Cancer Hospital (Cancer Hospital) who are receiving radiation treatment for cancer of the head and/or neck…
- Trial name
- NCT00862550
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Squamous Cell Carcinoma of Head and Neck
Toripalimab in Combined With Cetuximab，Chemotherapy for Conversion Therapy of Locally Nonresectable OCSCC
This is a prospective, single center phase II clinical study with a planned enrollment of 33 patients. The main objective is to evaluate the efficacy and safety of the PD-1 inhibitor toripalimab combined with cetuximab…
- Trial name
- NCT06081582
- Testing
- Toripalimab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Cervical Cancer, Endometrial Cancer
Topotecan in Treating Patients With Gynecologic Cancer That Cannot Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00842452
- Testing
- topotecan hydrochloride, pharmacological study
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Steven Waggoner, MD
Extensive-Stage Small Cell Lung Cancer
A Study of SYHA1807 in Subjects With Extensive-Stage Small Cell Lung Cancer
This is a phase I, open-label, multi-center, non-randomized, 2-part first time inhuman (FTIH) study for SYHA1807. Part 1 is a dose escalation phase to determine the recommended phase 2 dose (RP2D) for SYHA1807 based on the…
- Trial name
- NCT04404543
- Testing
- SYHA1807
- Volunteers
- 71 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Mouth Neoplasms
Oral Cancer Adjuvant Therapy (OCAT) Trial
To demonstrate whether addition of Concurrent chemotherapy to post-operative adjuvant radiotherapy OR shortening of duration of post-operative radiotherapy, by administering 6 fractions / week instead of 5 fractions / week…
- Trial name
- NCT00193843
- Testing
- Post-operative chemoradiotherapy / accelerated radiotherapy
- Where
- India
- Volunteers
- 900 people
- Sponsor
- Tata Memorial Hospital
Adult Giant Cell Glioblastoma, Adult Glioblastoma
Gefitinib and Radiation Therapy in Treating Patients With Glioblastoma Multiforme
This phase I/II trial studies the side effects and best dose of gefitinib when given together with radiation therapy and to see how well it works in treating patients with glioblastoma multiforme.
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
- Trial name
- NCT00052208
- Testing
- gefitinib, radiation therapy, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- National Cancer Institute (NCI)
Barrett Esophagus, Esophageal Adenocarcinoma
Trans-Oral Sampling as an Alternative Surveillance of Barrett's Esophagus Pilot
The study aims to address the increasing incidence of esophageal cancer and Barrett's esophagus (BE) in the Western world by exploring a more efficient surveillance method.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Diagnosis
- Trial name
- TOSS pilot (NCT07490340)
- Testing
- trans oral sampling: endosign
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pain, Nasopharyngeal Carcinoma
Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients
The primary purpose of this study is to explore the significance of analgesic treatment for radiation-induced oral mucositis pain in patients with nasopharyngeal carcinoma during radiotherapy, and to compare the analgesic effect…
- Conditions
- Pain, Nasopharyngeal Carcinoma, Head and Neck Cancer, Radiation Induced Oral Mucositis
- Trial name
- NCT04292990
- Testing
- Fentanyl, Morphine
- Volunteers
- 300 people
- Sponsor
- Jiarong Chen, MD
Head and Neck Cancer, Oral Cancer
Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT
The aim 1 of this trial is the development of the Circulating tumor cells (CTCs) definition of oral cancer minimal residual disease (MRD), and aim 2 is a prospective trial of oral cancer treatment.
- Trial name
- NCT07296250
- Testing
- low-dose oral chemotherapy
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.