Clinical trials: Oral Lichen Planus
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Mouth Neoplasms
Oral Cancer Screening for Early Detection of Premalignant Disorders (PMOD)
Cancer is a complex disease; its different causes and types have a strong impact on patient treatment and prognosis. To improve understanding of the disease, its causes and progression, the investigators will develop a simple…
- Trial name
- PMOD (NCT05296941)
- Testing
- Brush sampling
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Oral Lichen Planus
The Regulatory Role of Immune Response in Oral Lichen Planus
Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it.
- Trial name
- NCT05997173
- Testing
- Control, Non erosive OLP, Erosive OLP
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Oral Lichen Planus
Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and is considered a precancerous condition.
- Trial name
- NCT05973097
- Testing
- total glucosides of paeony treatment, photodynamic therapy treatment, glucosides of paeony and photodynamic therapy combined treatment
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Oral Lichen Planus
Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension
Lesions of the lichen planus type within the oral mucosa are now considered a potentially cancerous condition. One of the minimally invasive methods of treating these lesions is photodynamic therapy, and the gold standard in…
- Trial name
- NCT04991012
- Testing
- PDT Therapy, Triamcinolone (Substance) therapy side
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Lichen Planus, Oral
Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus
Lichen planus is a chronic inflammatory dermatosis. It most often affects the skin and mucous membranes. Sometimes lesions may appear in the area of nails (estimated at 10% of patients) or genital organs and anus.
- Trial name
- NCT04976673
- Testing
- Triamcinolone Acetonide, Photodynamic Therapy
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Lichen Planus, Oral
Study on Treatment for Patients With Symptomatic Oral Lichen Planus
The primary objective of this study was to compare the therapeutic efficacy of Tacrolimus gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from symptomatic OLP.
- Trial name
- NCT04718311
- Testing
- Oral lichen clinical Healing evaluation
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Catania
Lichen Planus, Oral, Preneoplastic Condition
Treatment Protocols for Patients With Symptomatic Oral Lichen Planus
The primary objective of this study was to compare the therapeutic efficacy of clobetasol propionate 0.05% oral gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from…
- Trial name
- NCT04673916
- Testing
- Healing evaluation
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Messina
Oral Lichen Planus, Thyroid Diseases
Association of Oral Lichen Planus and Thyroid Disease
Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is…
- Trial name
- NCT04523077
- Testing
- determination of thyroid hormones and antibodies
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Lichen Planus
Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients
Lichen planus is an auto-immune, chronic inflammatory disease that affects mucosal and cutaneous tissue. Erosive and atrophic oral lichen planus (OLP) are difficult to manage because patients present with symptoms ranging from…
- Trial name
- NCT04278599
- Testing
- Oral Zinc supplementation
- Where
- India
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Lichen Planus
Effect of Adjunctive Systemic Vitamin E on Clinical Parameters and Salivary Total Antioxidant Capacity in Symptomatic Oral Lichen Planus Patients: Randomized-controlled Clinical Trial
Treatment of oral lichen planus is challenging. Diverse therapeutic modalities have been suggested, but a permanent cure is not yet available.
- Trial name
- NCT04126720
- Testing
- topical corticosteroids and vitamin E suplements
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial
The aim of the present investigation is to assess the clinical therapeutic effect of topical use of Coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus and determine whether the effect, if…
- Trial name
- NCT04091698
- Testing
- Co-Enzyme Q10 mucoadhesive tablets
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid
Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients.
- Trial name
- NCT03871114
- Testing
- Triamcinolone Acetonide in orabase
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients
Introduce a new anti-inflammatory and antioxidant paste preparation (curcumin paste) in the management of Oral lichen planus. Assess the efficacy of this preparation on pain, clinical parameter and the level of IL-33 in saliva.
- Trial name
- NCT03877679
- Testing
- Triamcinolone, Turmeric paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus
Using of herbal medications as topical chamomile which has antioxidant, anti-inflammatory and anticarcinogenesis effect with little side effects is the aim for the future treatment of OLP.
- Trial name
- NCT03793634
- Testing
- topical chamomile
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Management of Pain in Oral Lichen Planus
Treating Oral Lichen Planus (OLP) is a big challenge for clinicians. Despite numerous existing remedies, to date no effective cure has been found, which is mainly attributed to the lack of understanding of the pathogenesis of the…
- Trial name
- NCT03572959
- Testing
- 0.1 % topical triamcinolone acetonide, SIROIaser
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sherine Adel Nasry
Oral Mucosal Disease
Clinical Research Core Dental Screening Protocol
This study will screen patients for eligibility in studies sponsored by the Craniofacial Genetics Section (HCGS), the Clinical Research Core (CRC), and other branches located within the National Institute of Dental and…
- Trial name
- NCT00090818
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Oral Lichen Planus, Oral Squamous Cell Carcinoma
Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity
The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.
- Trial name
- NCT03026361
- Testing
- global proteomic profiling
- Where
- Croatia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Oral Lichen Planus
Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus
The study included forty individuals divided into 3 groups. 10 control subjects, 15 oral lichen planus (OLP) patients who were treated with topical corticosteroids and 15 oral lichen planus (OLP) patients who were treated with…
- Trial name
- NCT02329600
- Testing
- green tea tablets (Green tea extract 5:1) 200 mg, Triamcinolone Acetonide
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University