Clinical trials: Oral Mucosa
Oral Mucosa Discomfort, Pediatric Cancer
Music Therapy for Oral Mucositis Pain in Pediatric Patients
This mixed-methods pilot study will examine the effect of music therapy on oral mucositis pain in pediatric oncology patients. Oral mucositis, characterized by painful ulcerative lesions in the mouth, is a common side effect of…
- Conditions
- Oral Mucosa Discomfort, Pediatric Cancer, Mucositis Oral
- Trial name
- NCT07653360
- Testing
- Semi-Structured Interviews
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oral Pain, Oral Pungent Sensation
Efficacy of Oral HA35 for Rapid Relief of Oral Pain and Pungent Sensation
This prospective, open-label, controlled pilot study evaluates oral 10% 35 kDa hyaluronan (HA35) versus four control interventions (C60 grapeseed oil，normal saline) for relief of capsaicin/AITC-induced oral pain and pungent…
- Conditions
- Oral Pain, Oral Pungent Sensation, Capsaicin-Induced Pain, AITC-Induced Irritation
- Trial name
- NCT07630571
- Testing
- Capsaicin Oral Challenge, Allyl Isothiocyanate (AITC) Oral Challenge, 10% 35 kDa Hyaluronan (HA35) Oral Solution
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Buccal Mucosa Squamous Cell Carcinoma, Floor of Mouth Squamous Cell Carcinoma
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer.
- Conditions
- Buccal Mucosa Squamous Cell Carcinoma, Floor of Mouth Squamous Cell Carcinoma, Gingival Squamous Cell Carcinoma, Hard Palate Squamous Cell Carcinoma
- Trial name
- NCT04333537
- Testing
- Chest Radiography, Computed Tomography, Fludeoxyglucose F-18
- Where
- 107 sites in United States, Canada
- Volunteers
- 686 people
- Sponsor
- NRG Oncology
OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
The Importance of Mucosal Screening in the Prevention of Oral Cancer.
Patients attending the Department of Oral Mucosal and Periodontal Diseases at the University Dental Center of the Medical University of Warsaw who provide written informed consent will be invited to participate in the study.
- Conditions
- OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Potentially Malignant Lesions, Leukoplakia Oral
- Trial name
- NCT07682883
- Testing
- Fluorescent oral examination (FOE), Conventional oral examination
- Where
- Poland
- Volunteers
- 1,383 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Precancerous Lesions of the Oral Mucosa
Autofluorescence for the Screening of Precancerous and Malignant Lesions
Diagnosis of oral squamous cell carcinoma is always too late. Due to this delay for diagnosis, prognosis is very bad. It has been demonstrate that systematic oral examination decrease mortality in tobacco and alcohol consumers…
- Trial name
- FLUOK (NCT01167790)
- Testing
- buccal cavity examination
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Bordeaux
Damaged Oral Mucosa
Evaluation of Mouthwash Use in Hygiene and Recovery After Interventions in Gums
The goal of this study was to learn if mouthwash works in aiding the healing of the gum tissue after trauma or dental procedure.
- Trial name
- NCT07385586
- Testing
- Repairing mouthwash
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lacer S.A.
Oral Lichen Planus, Oral Leukoplakia
Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders
Oral potentially malignant disorders (OPMDs) are mucosal lesions that carry a risk of malignant transformation into oral cancer.
- Conditions
- Oral Lichen Planus, Oral Leukoplakia, Traumatic Ulcer of Oral Mucosa, Erythroleukoplakia of Mouth
- Trial name
- NCT07318922
- Testing
- Toluidine blue staining of the lesion and cytological smears
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Traumatic Ulcer of Oral Mucosa
Evaluation of Low Level Laser Therapy and Lidocaine Versus Chlorhexidine for the Management of Traumatic Oral Ulcers in Children
the goal of the study was to evaluate the pain reduction and healing efficiency of traumatic oral ulcers in children using low-level laser therapy with diode laser 980 nm, lidocaine oral gel and chlorhexidine mouthwash
- Trial name
- NCT07138586
- Testing
- low level laser therapy group, Lidocaine gel group, Chlorhexidine mouthwash group (positive control group).
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Research Centre, Egypt
Oral Mucosa; Ulcer
Comparison of the Effects of Oral Ulceration Healing in Patients Wearing a Removable Denture
The aim of the study was comparing the effectiveness of oral mucosa healing properties of different preparations: CHX=0,2% chorhexidine digluconate, CHS=8,7% choline salicylate, CON=control group, in patients with delivered…
- Trial name
- MUCOSA HEALING (NCT06531720)
- Testing
- Chlorhexidine Gluconate, Choline Salicylate 8.7 % Oral Gel, control group
- Where
- Poland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Behçet Disease Affecting Oral Mucosa
Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers
Although Behçet's Disease (BD) has no FDA-approved therapies, numerous clinical reports suggest that oral ulcers of BD may resolve when treated with systemic ingested pentoxifylline (PTX).
- Trial name
- NCT03888846
- Testing
- Pentoxifylline, Colchicine
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Ipekyolu Ilac Ltd. Sti
Other Lesions of Oral Mucosa
The Investigation of a Fluorescence/Elastic Scattering Spectroscopy (F-ESS) Device for Oral Tissue Characterization
The overall objective of this work is to identify changes in the optical properties of oral tissues to develop a non-invasive tool for the detection, diagnosis and screening of oral pathology so that treatment can be provided at…
- Trial name
- NCT00764569
- Testing
- Fluorescence/Elastic Scattering Spectroscopy
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Oral Squamous Cell Carcinoma, Carcinoma of Buccal Mucosa
Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study
This is a phase II randomized clinical trial to study the effect of COX-2 inhibitor Celecoxib and EGFR tyrosine kinase inhibitor Erlotinib alone or in combination on molecular markers of apoptosis and angiogenesis.
- Conditions
- Oral Squamous Cell Carcinoma, Carcinoma of Buccal Mucosa, Tongue Cancers, Head and Neck Cancers
- Trial name
- ERLO-XIB (NCT02748707)
- Testing
- Arm1, Arm 2, Arm 3
- Where
- India
- Volunteers
- 64 people
- Sponsor
- Tata Memorial Hospital
Oral Mucosa
The Effectiveness and Safety of Mucoadhesive Film Containing A.Oleracea Extract
Several natural products have been use to promote wound healing and relieve pain. Acmella oleracea has a component that has anesthetic and anti-inflammatory properties.
- Trial name
- NCT05219747
- Testing
- Mucoadhesive film containing Acmella oleracea extract, Mucoadhesive film without Acmella oleracea extract
- Where
- Thailand
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Burning Mouth Syndrome, Oral Mucosa Disease
Head Yuanshi Dian Therapy in Burning Mouth Syndrome
Burning mouth syndrome is one of the most common oral mucosal diseases in clinic. It is a chronic pain syndrome with extensive burning pain of oral mucosa as its main symptoms.
- Trial name
- NCT04481841
- Testing
- oryzanol + vitamin B2 (riboflavin) + vitamin E
- Where
- 3 sites in China
- Volunteers
- 290 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Oral Mucosa
Diagnostic Markers of Neuropathic Odontalgia
The DIAMOND study aims to investigate the presence and diagnostic relevance of potential biomarkers of the blood-nerve barrier disruption as surrogate markers of painful post-traumatic trigeminal neuropathic pain in patients…
- Trial name
- DIAMOND-1 (NCT04142918)
- Testing
- Immunostaining
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Erythroleukoplakia of Mouth, Verrucous Hyperplasia of Oral Mucosa
A Study to Evaluate the Efficacy and Safety of Radion™-Pdt in Patients With Oral Precancerous Lesion
A Prospective, Single-Arm, Open-Label, Phase II Study to Evaluate the Efficacy and Safety of Photodynamic Therapy Using Radion™-pdt in Patients with Oral Precancerous Lesion (Oral Verrucous Hyperplasia or Oral Erythroleukoplakia).
- Trial name
- NCT03279744
- Testing
- Radion™-pdt
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Pharma Power Biotec Co., Ltd.
Neoplasm, Oral Mucosa
Topical Phenylephrine Solution in Preventing Oral Mucosa in Bone Marrow Transplant Patients Receiving Cyclophosphamide and Total Body Radiation Therapy
This phase I/II trial studies the safety of topical phenylephrine solution and to see how well it works in preventing oral mucosa (mouth sores) in bone marrow transplant patients receiving cyclophosphamide and total body…
- Conditions
- Neoplasm, Oral Mucosa, Transplant-Related Disorder
- Trial name
- NCT02434146
- Testing
- Topical Phenylephrine Solution
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Wisconsin, Madison
Ultrasound, Oral Mucosa
Sonographic Imaging of Oral and Dental Anatomical Structures (A Pilot Study)
The overall purpose of this study is to establish an ultrasound technique to aid in oral and dental examination of soft and hard tissues.
- Conditions
- Ultrasound, Oral Mucosa, Gingival Recession, Alveolar Bone Loss
- Trial name
- NCT03657589
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Fibrous Hyperplasia on Oral Mucosa
Comparison of ER:YAG Laser, CO2 Laser and Scalpel Excision of Fibrous Hyperplasia on the Buccal Mucosa
The aim of the RCT is to analyse clinical and histopathological particularities for excisional biopsies of fibrous hyperplasia in the buccal mucosa performed with Er:YAG laser, CO2 laser and scalpel.
- Trial name
- NCT03001791
- Testing
- Excisional biopsy with Er:YAG laser, Excisional biopsy with CO2 laser, Excisional biopsy with scalpel
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Bern