Clinical trials: Oral Mucosa
Gingival Recession, Lack of Keratinized Gingiva
A Comparison of Side Access Mucosal Releasing Incision (SAMRI) and Sulcular Tunnel Access to Treat Gingival Recession.
This study will compare two incision designs to allow for coronal gingival/mucosal flap advancement and tissue augmentation with acellular dermal matrix (ADM) graft around teeth with gingival recession and a lack of adequate…
- Trial name
- NCT04179448
- Testing
- SAMRI, STA
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Oral Mucosal Disorder
3M Oral Rinse Incidence and Patient Acceptance of Sloughing When Used With Sodium Lauryl Sulfate (SLS) Toothpastes
The primary objective of this study is to evaluate the incidence of oral tissue sloughing through self-report by study subjects and by professional dental examinations.
- Trial name
- NCT04601103
- Testing
- No SLS toothpaste, Medium SLS toothpaste, High SLS toothpaste
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Healthy
Oral Mucosal Absorption Study of Bicalutamide New Formulation
The purpose of this study is to investigate the presence or absence of oral mucosal absorption of bicalutamide after ICI176,334.1 is given to Japanese healthy male subjects
- Trial name
- NCT01416883
- Testing
- ICI176,334-1
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Eosinophilic Esophagitis
Comparison of Esophageal Clearance Times of Oral Budesonide Preparations
The purpose of this study is to determine if a xanthan gum or honey based budesonide slurry exhibit comparable mucosal contact time to a budesonide/sucralose slurry in healthy adult subjects.
- Trial name
- NCT02125851
- Testing
- Xanthan Gum, Honey
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Oral Lichen Planus
Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension
Lesions of the lichen planus type within the oral mucosa are now considered a potentially cancerous condition. One of the minimally invasive methods of treating these lesions is photodynamic therapy, and the gold standard in…
- Trial name
- NCT04991012
- Testing
- PDT Therapy, Triamcinolone (Substance) therapy side
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
The Importance of Mucosal Screening in the Prevention of Oral Cancer.
Patients attending the Department of Oral Mucosal and Periodontal Diseases at the University Dental Center of the Medical University of Warsaw who provide written informed consent will be invited to participate in the study.
- Conditions
- OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Potentially Malignant Lesions, Leukoplakia Oral
- Trial name
- NCT07682883
- Testing
- Fluorescent oral examination (FOE), Conventional oral examination
- Where
- Poland
- Volunteers
- 1,383 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Anesthesia
The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia
This study tests whether using an Er,Cr:YSGG laser before applying numbing gel (lidocaine) can help reduce pain during dental procedures compared to traditional methods.
- Trial name
- NCT07169032
- Testing
- Er,Cr:YSGG laser irradiation, Lidocaine, Vaseline
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Li Zhen Zhong
Burning Mouth Syndrome
Neurogenic Mechanisms in Burning Mouth Syndrome
Burning mouth syndrome (BMS) is characterized by a bilateral burning sensation in the anterior tongue, hard palate and lips in the absence of any clinical or laboratory findings.
- Trial name
- BMS17 (NCT00875537)
- Testing
- Capsaicin oral gel 0.025%, Capsaicin oral gel 0.01%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Oral Hygiene, Toothbrushing
Open-label Trial Evaluating Four Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste, and Mouthwash
The purpose of this open-label, randomized controlled clinical trial, is to provide preliminary clinical data (efficacy on plaque and gingival sensitivity, and safety and tolerability of two types of toothpaste, a mouthwash, and…
- Conditions
- Oral Hygiene, Toothbrushing, Dental Plaque
- Trial name
- NCT05999175
- Testing
- the toothpaste is used with a standard toothbrush without any claims 3 times a day after the main meals for 28 days., the mint toothpaste and mouthwash are used with the scalar toothbrush 33 medium with antibacterial " Spazzolino tau-marin®" 3 times a day after the main meals for 28 days., subjects of this group will use their routine oral hygiene products.
- Where
- 2 sites in Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Biokosmes Srl
Healing Surgical Wounds, Pain Measurement
Effects of Laser Stimulation on Wound Healing of Human Palatal Tissue
The purpose of this study is to assess the effects of photobiomodulation (PBM) with an Er:YAG laser on the palatal donor site following subepithelial connective tissue graft (SECTG) surgery.
- Trial name
- NCT03741062
- Testing
- J. Morita AdvErl Evo Er:YAG laser, Control
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Peri-Implantitis, Peri-implant Mucositis
Predictive Value of Reduced Keratinized Mucosa on the Secondary Prevention of Peri-implant Mucositis and Periimplantitis in Patients Attending Regular Supportive Peri-implant Care. A Longitudinal Analysis
Capture of the potential risk factor "lack of band of keratinised mucosa" over a period of up to 5 years. Recording of peri-implant inflammatory processes in study participants that are not recorded during normal tooth cleaning…
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Lack of Keratinized Gingiva
- Trial name
- NCT05804760
- Testing
- Measurement of implant parameters
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Shigella
Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa
The purpose of this study is to determine whether CVD 1208S (a live, attenuated, oral vaccine) is safe and effective in the prevention of Shigella infection.
- Trial name
- NCT00866476
- Testing
- CVD 1208S, a Shigella flexneri 2a live, oral vaccine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Alcohol Drinking, Alcohol Use, Unspecified
Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use
This is the first clinical trial of Endourage OMD 1200 for persons desiring to reduce their alcohol consumption.
- Conditions
- Alcohol Drinking, Alcohol Use, Unspecified, Alcohol Abstinence, Alcohol-Related Disorders
- Trial name
- NCT04659278
- Testing
- Endourage 1200 mg OMD ™ Oral Mucosal Drops, Isolate, Peppermint Oil, masking flavor
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Endourage, LLC
Initiation of Oral Contraception (OC), Initiation of Depo-Provera (DMPA)
Modulation of Mucosal and Systemic Immunity by Hormonal Contraceptives
The investigators are conducting a research study to understand how cells responsible for fighting infection (immune cells) are affected by hormonal contraceptive use.
- Conditions
- Initiation of Oral Contraception (OC), Initiation of Depo-Provera (DMPA), Initiation of Mirena (LNG-IUD)
- Trial name
- NCT01750476
- Testing
- Mirena, Oral contraception, Depo-Provera
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Thomas Cherpes, DVM, MD
Oral Mucosa; Ulcer
Comparison of the Effects of Oral Ulceration Healing in Patients Wearing a Removable Denture
The aim of the study was comparing the effectiveness of oral mucosa healing properties of different preparations: CHX=0,2% chorhexidine digluconate, CHS=8,7% choline salicylate, CON=control group, in patients with delivered…
- Trial name
- MUCOSA HEALING (NCT06531720)
- Testing
- Chlorhexidine Gluconate, Choline Salicylate 8.7 % Oral Gel, control group
- Where
- Poland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Healthy
Safety Oral Mucosa Evaluation - Acceptability With Odontological Follow up - Cepacol Canela Power
To prove the safety, in normal conditions, of the odontological use formulation of the product Cepacol Canela Power.
- Trial name
- NCT00687037
- Testing
- Cetylpyridinium chloride
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sanofi
Mumps, Measles
Immunity in Persons Fully Vaccinated Against Measles, Mumps and Rubella and Responses to Booster Vaccination
The purpose of this study is to investigate the immunity of persons fully vaccinated against measles, mumps and rubella and to examine the course of immunity after booster vaccination.
- Conditions
- Mumps, Measles, Rubella
- Trial name
- MIPS (NCT05894395)
- Testing
- MMR booster vaccination (as M-M-R-VaxPro)
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Safety Issues
Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations
To study the oral mucosal effects in adult smokers associated with the use of two Nicotine Lozenge formulations.
- Trial name
- NCT03087786
- Testing
- Nicotine Bitartrate Lozenge 4mg, Nicotine Polacrilex 4Mg Lozenge
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Niconovum USA
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Smokers
Oral Mucosal Lesions Among Smokers in an Egyptian Population Study.
This cross-sectional study will assess the prevalence of oral changes among smokers in an Egyptian cohort (patients attending to the hospital of Faculty of Dentistry - Cairo University), aiming that this study can serve as a…
- Trial name
- NCT03299634
- Testing
- printed questionnaire
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Cairo University