Clinical trials: Oral Soft Tissue Conditions
Oral Soft Tissue Conditions
Peri Implant Soft Tissue Healing in Single Implant Restoration Using Two Different Techniques
The aim of the present study was to propose the employment of Bio-Oss® and Bio-Gide® at implant site in order to evaluate if the increased bucco-lingual bone thickness could enhance the stability of peri implant soft tissue, when…
- Trial name
- NCT02513368
- Testing
- augmentation procedure with Bio-Oss® and Bio-Gide®, augmentation procedure with connective tissue graft
- Where
- 2 sites in Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Firenze and Siena, Napoli, Italy
Molar, Third, Third Molar Surgery
3D Evaluation of Postoperative Edema After Third Molar Surgery
Surgical removal of third molars is recognized as one of the most frequent procedures performed in oral surgery. Literature is rich in studies attempting to demonstrate the benefit of corticosteroids in third molar surgery…
- Conditions
- Molar, Third, Third Molar Surgery, Soft Tissue Swelling, Pain, Postoperative
- Trial name
- NCT05941130
- Testing
- Combination of corticosteroid (methylprednisolone - Medrol, 16mg Pfizer Laboratories) therapy and non-steroidal anti-inflammatory (Ibuprofen 600mg Mylan) therapy, Non-steroidal anti-inflammatory therapy (Ibuprofen 600mg Mylan)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Vasoconstriction, Oral Soft Tissue Conditions
Evidence of Spreading Vasoconstriction in Human Gingiva
The aim of this study is to observe the mechanism of spreading vasoconstriction in human healthy gingiva. Epinephrine solution is applied on the attached gingiva in group "A" and on the surface of the tooth next to the ginvial…
- Conditions
- Vasoconstriction, Oral Soft Tissue Conditions, Dental and Gingival Conditions
- Trial name
- NCT04131283
- Testing
- Epinephrine
- Where
- Hungary
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Oral Soft Tissue Conditions
A Comparative Clinical Study Between a Collagen Matrix and Collagen Membrane as Wound Protection During Ridge Preservation ARP
Patients in need of extraction of two teeth in combination with alveolar ridge preservation will be invited to participate in intra-subject RCT on ARP. Prior to surgery, a small-field low-dose CBCT is taken.
- Trial name
- ARP (NCT06029322)
- Testing
- Socket seal after alveolar ridge preservation
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Chronic Myeloid Leukemia, Gastrointestinal Stromal Tumor
A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)
1. Investigational Product 1. Imatinib mesylate tablet 400 mg 2. Glivec film-coated tablet 100 mg (Comparator) 2. Expected target disease 1. chronic myeloid leukemia 2. Gastrointestinal stromal tumors 3.
- Trial name
- NCT01751919
- Testing
- Imatinib mesylate tablet 400 mg, 1 Tablet, Glivec film-coated tablet 100 mg, 4 Tablets
- Where
- South Korea
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Nitric Oxide, Vasodilation
Evidence of Spreading Vasodilation in Human Gingiva
The aim of this study is to observe the mechanism of spreading vasodilatation on human healthy gingiva. Nitric-oxide donor solutions in lower and higher concentration are used to trigger the vasoactivity.
- Conditions
- Nitric Oxide, Vasodilation, Oral Soft Tissue Conditions
- Trial name
- NCT03605095
- Testing
- nitroglycerin
- Where
- Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Vasodilation, Oral Soft Tissue Conditions
Investigation of Endothelium-dependent Vasodilation in Human Gingiva
The first aim of this study is to create a cumulative dose-response curve for acetylcholine in men (low serum estrogen levels) to determine the lowest concentration with which we can induce a maximal vasodilation effect on the…
- Trial name
- NCT06454084
- Testing
- Acetylcholine Chloride
- Where
- Hungary
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Cleft Lip and Palate, Periodontal Pocket
Periodontal Changes Following Mid Maxillary Distraction
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
- Conditions
- Cleft Lip and Palate, Periodontal Pocket, Attachment Loss, Periodontal
- Trial name
- NCT03686761
- Testing
- A Involvement with the osteotomy site of the surgery
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Metrorrhagia, Pelvic Pain
Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL)
In this project, the proposition is that the use of daily dosed Myfembree ( a combination of relugolix with estradiol and norethindrone acetate), FDA-approved medication to treat heavy menses fibroid-related symptoms, has the…
- Conditions
- Metrorrhagia, Pelvic Pain, Menorrhagia, Leiomyoma
- Trial name
- SOUL (NCT05538689)
- Testing
- Myfembree Oral Product
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Cellulitis
Oral Moxifloxacin Versus Cefazolin and Oral Probenecid in the Management of Skin and Soft Tissue Infections in the Emergency Department
Patients often come to the emergency department with bacterial skin infections (known as "cellulitis"). Some patients with very severe infections are admitted to hospital for antibiotic treatment and some are sent home on oral…
- Trial name
- NCT00323219
- Testing
- Cefazolin and Moxifloxacin
- Where
- Canada
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Oral Soft Tissue Conditions
Phytotherapy Agent in Third Molar Surgery
The aim of the present study was to evaluate the effect of a phytotherapy agent on clinical and inflammatory parameters, for the postoperative therapy of the impacted third molar surgery.
- Trial name
- NCT03335683
- Testing
- Lenidase
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gaetano Isola, DDS, PhD
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Wound Heal, Wound Surgical
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part III
The purpose of the present study is to evaluate the effect of Hyaluronic acid application in the gene expression profile and cellular behavior in the early wound healing process -24 hours after injury- of the oral soft tissues.
- Conditions
- Wound Heal, Wound Surgical, Oral Soft Tissue Conditions, Hyaluronic Acid
- Trial name
- NCT04865952
- Testing
- periodontal surgery + 24 hr buccal attached gingiva (G) biopsy, HA application
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Digital Technology, Prosthesis User
3D Evaluation of the Lip Support in a Full-arch Implant-supported Rehabilitations
The goal of this observational study is to evaluate the impact of a full arch implant-supported prostheses in the lip support. In a complex rehabilitation cases, the process between the diagnosis and the delivery of a prostheses…
- Conditions
- Digital Technology, Prosthesis User, Lip, Oral Soft Tissue Conditions
- Trial name
- NCT06052501
- Testing
- Removable of the full arch implant-supported prostheses
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Pain, Postoperative, Wound Heal
Clinical Efficacy of Soft Tissue Trimmer in Cases of Gingival Hyperplasia.
Postoperative pain and wound healing are compared after using conventional scalpel technique in comparison with the intervention which is using Soft tissue Trimmer for cases of gingival hyperplasia.
- Conditions
- Pain, Postoperative, Wound Heal, Gingival Hyperplasia
- Trial name
- NCT04542486
- Testing
- Excision of gingival hyperplasia using "Soft tissue trimmer "., Excision of gingival hyperplasia using the conventional scalpel technique
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vasodilatation, Oral Soft Tissue Conditions
Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva
The aim of this study is to compare the endothelim-dependent and non-dependent vasodilatation between genders in the human gingiva.
- Trial name
- NCT04918563
- Testing
- Nitroglycerin, Acetylcholine
- Where
- Hungary
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Oral Soft Tissue Conditions, Drug Effect
Flurbiprofen Tablet vs Spray In Oral Soft Tissue Wounds
The amount of active ingredient in tablet form of flurbiprofen is higher than that in the oral spray form. Therefore, based on the hypothesis that the side effects that may occur depending on the dose can be reduced, this…
- Conditions
- Oral Soft Tissue Conditions, Drug Effect, Drug Use
- Trial name
- NCT06238154
- Testing
- Flurbiprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Localized Gingival Enlargement, Epulides
Periodontal Plastic Reconstruction of Soft Tissue Dehiscences After the Removal of Localized Gingival Enlargements
Non-inflammatory recessions and Miller class I-II-III. mucogingival defects after elimination of localized gingival enlargements are frequently encountered challenges in the daily practice. In Miller class II-III.
- Conditions
- Localized Gingival Enlargement, Epulides, Recurrence, Periodontal; Lesion
- Trial name
- NCT06210789
- Testing
- Surgical excision
- Where
- Hungary
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Semmelweis University