Clinical trials: Organ Dysfunction
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Pelvic Floor Disorders, Pelvic Organ Prolapse
Pelvic Floor Rehabilitation of Female Pelvic Floor Dysfunction
The goal of this observational study is to learn about the therapeutic effects of different pelvic floor rehabilitation treatments, including pelvic floor muscle training , pelvic floor biofeedback electrical stimulation, and…
- Trial name
- NCT06461234
- Testing
- Pelvic floor muscle training, Biofeedback electrical stimulation, Magnetic Stimulation
- Where
- China
- Volunteers
- 1,360 people
- Sponsor
- Mingfu Wu
Cardiovascular Diseases, Cardiovascular Morbidity
Assessment and Digital-health Based Intervention on Subclinical Organ Damage and Cardiovascular Risk in Chinese
To comprehensively evaluate subclinical organ damage of Chinese adults and its association with future cardiovascular disease and events.
- Conditions
- Cardiovascular Diseases, Cardiovascular Morbidity, Subclinical Organ Damage, Digital Health
- Trial name
- NCT05435898
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Shanghai 10th People's Hospital
Sepsis, Septic Shock
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis
This study seeks to elucidate the quantitative expression of G - protein receptor 43/free fatty acid (GPR43/FFA2) receptors in patients with the diagnosis of sepsis and specifically, its expression as it relates to the severity…
- Conditions
- Sepsis, Septic Shock, Multiple Organ Dysfunction, Intra-abdominal Sepsis
- Trial name
- GPR43Sepsis (NCT02699905)
- Testing
- phlebotomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Acute Aortic Syndrome, Aortopathy
Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)
Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year…
- Trial name
- PANDA (NCT04699279)
- Testing
- Rosuvastatin 10mg
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Critical Illness, Severe Sepsis
Near Infrared Spectroscopy (NIRS) in Severe Sepsis
The purpose of this study is to evaluate the usefulness of an optimization of muscle perfusion and oxygenation, as assessed by the NIRS technique, in critically ill patients with sepsis.
- Trial name
- OTO-STS (NCT00167596)
- Testing
- Near Infrared Spectroscopy, conventional
- Where
- 7 sites in France, Germany and 2 more
- Volunteers
- 103 people
- Sponsor
- University of Versailles
Septic Shock, Sepsis
Triple Therapy in Septic Shock Patients
this study is conducted to evaluate the role of the novel triple therapy combination in reducing the mortality rate, reducing the shock time, and reversal of organ damage.
- Conditions
- Septic Shock, Sepsis, Organ Dysfunction Syndrome Sepsis
- Trial name
- NCT04508946
- Testing
- vitamin c - thiamine- hydrocortisone
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- Air Force Specialized Hospital, Cairo, Egypt
Severe Sepsis, Septic Shock
Adrenomedullin and Outcome in Severe Sepsis and Septic Shock
The aim of this prospective study is to assess the prognostic value of bioactive plasma adrenomedullin (ADM) in 600 patients with severe sepsis or septic shock in an international multicenter study and to validate the findings…
- Trial name
- AdrenOSS (NCT02393781)
- Where
- 24 sites in Belgium, France and 3 more
- Volunteers
- 596 people
- Sponsor
- Sphingotec GmbH
Sepsis, Acute Gastrointestinal Injury
Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury
This study is a prospective, multicenter, parallel-group, open-label, randomized controlled clinical trial. Sepsis is defined as organ dysfunction induced by infections.
- Conditions
- Sepsis, Acute Gastrointestinal Injury, Organ Dysfunction Syndrome
- Trial name
- NCT05623722
- Testing
- Erector spinae plane block
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Jing Cai, MD
Severe Sepsis, Septic Shock
Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction
The trial enrolls patients with early severe sepsis or septic shock displaying at least one newly developed organ dysfunction and showing clinical evidence of pulmonary or abdominal infection.
- Trial name
- SCIENS (NCT02246595)
- Testing
- CaCP29
- Where
- 11 sites in Germany
- Volunteers
- 72 people
- Sponsor
- InflaRx GmbH
Sepsis, Echocardiography
Emergency Echocardiography in Sepsis
Acute circulatory failure that combines hypovolemia, vasoplegia and cardiac dysfunction plays a major role in the development of sepsis-related organ dysfunction. Pathophysiological mechanisms are multiple and complex.
- Conditions
- Sepsis, Echocardiography, Organ Dysfunction Syndrome Sepsis, Emergencies
- Trial name
- GENESIS (NCT04580888)
- Testing
- early transthoracic echocardiography, standards of care
- Where
- 10 sites in France
- Volunteers
- 312 people
- Sponsor
- University Hospital, Limoges
Critical Illness, Multiple Organ Failure
Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS Study
The goal of this observational study is to learn whether adding a gastrointestinal (GI) component to a widely used organ failure score improves the prediction of death risk in critically ill adults treated in the intensive care…
- Conditions
- Critical Illness, Multiple Organ Failure, Gastrointestinal Diseases, Mortality
- Trial name
- SOFA2-GIS (NCT07586254)
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- Ozkul Yilmaz Colak
Inflammation, Bone Metabolism
Effects of Femoral Canal Opening Technique on Biomarkers
This single-centre prospective randomized study consisted of 60 participants (50 women) with a mean age of 80.33 ± 11.13 years, randomly allocated to either manual medullary canal opening (n = 30) or mechanical drilling of the…
- Trial name
- NCT07648719
- Testing
- medullary canal opening
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University of Split, School of Medicine
Pelvic Organ Prolapse
Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse
This study will evaluate the effect of pessary therapy, with and without Solifenacin (Vesicare), on symptoms of over active bladder and bladder function in women with overactive bladder symptoms and pelvic organ prolapse.
- Trial name
- PESSARY (NCT01092624)
- Testing
- Solifenacin, Ring pessary with support, Cooper Surgical, Trumbell, CT Ref # MXPRS03 non-latex
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hartford Hospital
Congenital Heart Disease in Children, Cardiac Surgical Procedures
Predictive Pre and Peroperative Factors for MODS-2 in Pediatric Cardiac Surgery
Pediatric cardiac surgery has a relatively high morbi-mortality. Despite great advances in surgical techniques, today the mortality rate is about 3% and morbidity is about 30-40%.
- Conditions
- Congenital Heart Disease in Children, Cardiac Surgical Procedures, Outcome Assessment, Organ Dysfunction Scores
- Trial name
- FPMODS2 (NCT05284500)
- Testing
- Pediatric cardiac surgery with cardiopulmonary bypass
- Where
- Belgium
- Volunteers
- 152 people
- Sponsor
- Brugmann University Hospital
Renal Failure Acute, Multiple Organ Failure
Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.
- Conditions
- Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
- Trial name
- NCT05182723
- Testing
- renal replacement therapy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Graft vs Host Disease, Complications of Organ Transplant Stem Cells
CEC Count Changes to Support GvHD Diagnosis.
In consideration of the fact that the vascular endothelium has been shown to be a target of GvHD in early stage and that the count of CEC may represent a marker of endothelial damage, we want to evaluate the changes in CEC counts…
- Conditions
- Graft vs Host Disease, Complications of Organ Transplant Stem Cells, Endothelial Dysfunction
- Trial name
- ALLOCEC (NCT02064972)
- Testing
- Patients undergoing allo-HSCT, who manifest GvHD.
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Acute-On-Chronic Liver Failure, Ascites
Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®
A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrahepatic organ dysfunctions and…
- Trial name
- NCT05900050
- Testing
- VS-01 on top of SOC, SOC (Control Group)
- Where
- 26 sites in United States, Belgium and 5 more
- Volunteers
- 15 people
- Sponsor
- Genfit
Hypotension, Brain Injuries
Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Intraoperative hypotension (defined as mean arterial pressure below 65 mmHg) is associated with increased organs dysfunction and mortality.
- Conditions
- Hypotension, Brain Injuries, Renal Failure, Endothelial Dysfunction
- Trial name
- NCT03527758
- Testing
- Flo TracIQ with HPI software
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Systemic Inflammatory Response Syndrome, C.Surgical Procedure; Cardiac
Studying Complement Inhibition in Complex Cardiac Surgery
The trial enrolls patients undergoing a complex cardiac surgery. The primary goal of the trial is to evaluate the pharmacodynamic dose response relationship of the monoclonal antibody IFX-1 in these patients.
- Trial name
- CARDIAC (NCT02866825)
- Testing
- IFX-1
- Where
- 10 sites in Germany
- Volunteers
- 116 people
- Sponsor
- InflaRx GmbH