Clinical trials: Organ Failure
Liver Failure, Acute Kidney Disease
Intraoperative Dialysis in Liver Transplantation
Patient with liver failure waiting for liver transplantation are often hospitalized and commonly supported in an intensive care unit prior to surgery.
- Conditions
- Liver Failure, Acute Kidney Disease, Multi-organ Failure
- Trial name
- INCEPTION (NCT01575015)
- Testing
- Continuous renal replacement therapy (CRRT), Standard intraoperative support
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Critical Illness
Use of In-Line Filtration in Critically Ill Children
The purpose of this study is to determine whether the use of in-line filtration shows any effect on the outcome of sepsis, systemic inflammatory response syndrome (SIRS), thrombosis, or organ failure in critically ill children…
- Trial name
- NCT00209768
- Testing
- Filter: NOE96E, ELD96E, NLF1E, TNA1E
- Where
- Germany
- Volunteers
- 821 people
- Sponsor
- Hannover Medical School
Multiple Trauma
Proteomics in Multiple Trauma to Identify Organ Failure
To analyse differences in protein expression in multiple trauma patients for identification of potential biomarkers to predict organ dysfunction.
- Trial name
- NCT02030327
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT.
- Trial name
- SAVE (NCT06517810)
- Testing
- QUELIMMUNE (SCD-PED)
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- SeaStar Medical
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Efferon LPS Hemoadsorption in Cardiac Surgery Patients
This randomized controlled study aims to evaluate the efficacy and safety of intraoperative and early postoperative hemoadsorption using the Efferon® LPS device in patients undergoing cardiac surgery with cardiopulmonary bypass…
- Trial name
- NCT07532174
- Testing
- Efferon LPS
- Where
- 3 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Multiple Organ Failure
Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of SIRS in Heart Surgery Patients
Heart-surgery with the use of a heart-lung-machine can trigger the development of a full-blown SIRS (Systemic Inflammatory Response Syndrom) with multi organ failure and severe sepsis in the course of disease.
- Trial name
- CASHSP (NCT02265419)
- Testing
- Extracorporeal treatment with the Cytosorb adsorber
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Rostock
Trauma, Inflammation
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
The goal of this project, is to better understand the fluctuation of the level of uric acid in traumatized patients by making serial measurements during their hospitalization in the intensive care unit.
- Trial name
- NCT03622632
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy
Critical Illness Weakness Outside the Intensive Care Unit.
When people become seriously ill, their bodies can be affected in many ways beyond the original disease. One well-known complication in patients treated in intensive care units (ICUs) is the development of severe muscle weakness…
- Conditions
- Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- CRI-WEAK-OUT (NCT07478367)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Acute Hypoxemic Respiratory Failure
Is Hypoxemia Driving Outcome in Acute Hypoxemic Respiratory Failure? (HOMELAND Study)
Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in the intensive care units (UCIs) worldwide. The investigators will assess the value of mediation analysis (a statistical method to understand the…
- Trial name
- HOMELAND (NCT07708506)
- Testing
- mediation analysis
- Where
- 18 sites in Spain, United Kingdom
- Volunteers
- 1,241 people
- Sponsor
- Jesus Villar
Critically Ill, Organ Failure, Multiple
Heterogeneity of Critical Illness: a Cohort Study
Rationale: There is large heterogeneity in disease states of critically ill patients at ICU admittance and there is also large heterogeneity in their disease severity during ICU stay.
- Trial name
- HEALICS (NCT04502511)
- Testing
- Standard diagnosis test
- Where
- Netherlands
- Volunteers
- 5,000 people
- Sponsor
- University Medical Center Groningen
Sepsis, Severe Sepsis
Vitamin D Status in Patients With Severe Sepsis
Sepsis is a clinical entity that complicates infection. Without early recognition and timely management, it can rapidly progress to severe sepsis, septic shock, and culminate in multiple organ dysfunction syndrome.
- Conditions
- Sepsis, Severe Sepsis, End Organ Damage, Multi Organ Failure
- Trial name
- ViDISS (NCT02684487)
- Testing
- vitamin D3
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Acute-On-Chronic Liver Failure, Ascites
Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®
A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrahepatic organ dysfunctions and…
- Trial name
- NCT05900050
- Testing
- VS-01 on top of SOC, SOC (Control Group)
- Where
- 26 sites in United States, Belgium and 5 more
- Volunteers
- 15 people
- Sponsor
- Genfit
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Sepsis, Multiple Organ Dysfunction Syndrome
Bovine Intestinal Alkaline Phosphatase for the Treatment of Patients With Sepsis
Eligible patients will receive either AP or matching placebo in a double blind, randomized design and following a 2:1 ratio. All medication will be given in addition to standard care for sepsis patients.
- Trial name
- NCT00430859
- Testing
- Alkaline Phosphatase
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 37 people
- Sponsor
- AM-Pharma
Cirrhosis
To Study and Compare the Clinical Course and Development of Organ Failure in Severe Acute Hepatitis Without Ascites, Non-cirrhotic and Cirrhotic Patients With Ascites [Acute on Chronic Liver Failure] and Acute Deterioration of Previously Decompensated Cirrhosis.
The study will be conducted on patients admitted to Department of Hepatology from MARCH 2015 to DECEMBER 2016 at ILBS, New Delhi.All patients presenting to ILBS fulfilling the inclusion criteria will be included in the study and…
- Trial name
- NCT02465619
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Aortic Aneurysm, Spinal Ischaemia
Organ Failure After Advanced Endovascular Thoracoabdominal Aortic Surgery
The purpose of this study is to investigate the mortality and frequency of organ dysfunction in patients after endovascular thoracoabdominal aortic surgery, and to search for biomarkers of organ dysfunction, in particular the…
- Conditions
- Aortic Aneurysm, Spinal Ischaemia, Gastrointestinal Ischaemia
- Trial name
- ODEA (NCT03136536)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Örebro County
Pediatric Sepsis-induced MODS
GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study
This study is an open-label, multi-center, interventional trial in which children with sepsis-induced MODS undergo surveillance immune function testing beginning on Day 2 of MODS.
- Trial name
- GRACE (NCT03769844)
- Testing
- GM-CSF
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- Nationwide Children's Hospital
Brain Death, Renal Failure
Understanding Family Refusal
The investigators plan a secondary data analysis of an existing dataset to examine how individual decision-making differs from family decision-making in organ donation.
- Trial name
- NCT04303624
- Testing
- Health sciences survey
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Renal Failure, Chronic
Timing for Arteriovenous Fistula Creation and Its Effect on Target Organs in Patients With Chronic Renal Failure
The timing for arteriovenous fistula (AVF) creation and its effect on target organs in patients with chronic renal failure will be investigated by multicenter prospective cohort.
- Trial name
- TACTIC (NCT02259296)
- Testing
- Lower eGFR for AVF construction, Higher eGFR for AVF construction
- Volunteers
- 2,200 people
- Sponsor
- Shanghai Changzheng Hospital