Clinical trials: Organic Pollutant
Healthy
TEXTO : Total EXposure To Organic Pollutants
People are, especially in industrialized countries, exposed to a growing number of ubiquitous chemical substances. It thus increases human exposure pathways: diet, inhalation, soil and dust dermal contact…), notably for…
- Trial name
- TEXTO (NCT02210299)
- Testing
- Exposure study
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Prenatal Exposure, Postnatal Exposure
Exposure to Organochlorine Pollutants and Impact on Development in the Peripubertal Age in Guadeloupe
In the context of environmental pollution of the French West Indies by chlordecone and questions about health consequences, monitoring at the peripubertal age of children born alive in the TIMOUN cohort is justified in several…
- Trial name
- TIMOUNPUBERTY (NCT06653660)
- Testing
- Clinical examination
- Where
- Guadeloupe
- Volunteers
- 650 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Breast Cancer
Pregnant Exposure to Persistent Organic Pollutants
Breast cancer, the first female cancer, affects one in eight women in her lifetime. The increase and uneven distribution of its prevalence throughout the world cannot be fully explained either by the increase in life expectancy…
- Trial name
- NCT03419026
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Endometriosis
Exposure to Persistent Organic Pollutants and Severity of Endometriosis in the ComPaRe-Endometriosis Cohort
Endometriosis is a chronic inflammatory disease affecting ~10% of women of childbearing age. It is characterized by the presence of endometrial-like tissue outside the uterus, causing lesions and adhesions between the organs, and…
- Trial name
- POPENDO (NCT06973603)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type 2 Diabetes, Thyroid Cancer
Association Between Persistent Organic Pollutants and Type 2 Diabetes /Thyroid Cancer
Persistent organic pollutants (POPs) are a class of organic pollutants in the environment characterized by persistent, bioaccumulation, long-range transport and biological toxicity.
- Conditions
- Type 2 Diabetes, Thyroid Cancer, Organic Pollutant
- Trial name
- NCT05218395
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Obesity, Metabolic Syndrome
Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants
Obesity represents one of the most important public health challenges for the societies. Although excess energy intake and physical inactivity are major causes of obesity and cardiometabolic disorders, emerging evidence has…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT02589756
- Testing
- The fatty fish group, The nut group, The control group
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Obesity, Bariatric Surgery Candidate
Persistent Organic Pollutants and Mechanical Discharge: Limiting the Impact of Bariatric Surgery Through Personalized Adapted Physical Activity
For the most severe cases of obesity, recourse to bariatric surgery is the ultimate solution. Although highly beneficial to individual health, this massive loss of body mass could also have negative effects on metabolism and…
- Trial name
- PERSIST-APA (NCT06597617)
- Testing
- Adapted physical activity with aerobic training [GEA], Adapted physical activity with strength training [GRM]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Persistent Organic Pollutants, Endocrine Disrupting Chemicals
Nuts and Olestra for Persistent Organic Pollutant Reduction (NO-POPs) Trial
Persistent organic pollutants (POPs) are mostly fat-soluble halogenated chemicals with very long half-lives. POPs are endocrine disruptors, associated with increased risk for diabetes, alterations in thyroid function, and…
- Conditions
- Persistent Organic Pollutants, Endocrine Disrupting Chemicals, Endocrine Disruptor Effects
- Trial name
- NO-POPs (NCT02675101)
- Testing
- Whole Nuts, Olestra: Fat Free Pringles, Vegetable Oil: Original Pringles
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Endometriosis, Infertility Unexplained
Organic Pollutants in Pelvic Endometriosis
The health toxicity of polycyclic aromatic hydrocarbons (PAHs), present in air and food, generated during energy production and waste incineration, is well known.
- Trial name
- NCT05789407
- Testing
- Detection of PAHs in visceral fat with gas chromatography-isotope dilution mass spectrometry
- Where
- Poland
- Volunteers
- 46 people
- Sponsor
- Jagiellonian University
Exposure to Environmental Pollution
Characterization of Persistent Organic Pollutants Exposure During Preconception and Preimplantation Development.
In order to evaluate if gametes and preimplantation embryos are in vivo exposed to environmental chemicals, the detection of 6 molecules representative of 3 persistent organic pollutants families will be performed in the mucosa…
- Trial name
- TUBPOP (NCT04628091)
- Testing
- Sampling on surgery day
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Breast Cancer, Persistant Organic Pollutants
Persistant Organics Pollutants in Breast Cancer.
Persistant Organics Pollutants (POP) accumulate in the adipose tissue (AT) and could modulate tumor progression as part of the microenvironment.
- Conditions
- Breast Cancer, Persistant Organic Pollutants, Lymph Node Metastases
- Trial name
- METAPOP (NCT03788187)
- Testing
- Blood test sample, Peritumoral adipose tissue sample
- Volunteers
- 80 people
- Sponsor
- European Georges Pompidou Hospital
Pesticide, Breast Milk
Impact of Exposure to Persistent Organic Pollutants During Pregnancy on the Composition of Breast Milk and Consequences on the Newborn
Epidemiological studies link early exposure to persistent organic pollutants (POPs) with health consequences in the newborn. Experimental studies have shown the impact of POPs on the gut microbiota.
- Conditions
- Pesticide, Breast Milk, Pollution; Exposure, Meconium
- Trial name
- PESTIMICOBLAIT (NCT03969459)
- Testing
- breast milk collection, meconium collection, newborn feces collection
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Obesity, Abdominal, Diabetes
Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients
Environmental endocrine disruptors (EDCs) represent a major problem for human health.Some PEEs can accumulate in the fatty tissue of the human body thanks to their lipophilic nature, and are known as persistent organic pollutants…
- Conditions
- Obesity, Abdominal, Diabetes, Bariatric Surgery Candidate
- Trial name
- OBESE (NCT05966727)
- Testing
- Cholestyramine Powder
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Breast Milk Collection
the Study of Persistent Organic Pollutants in Human Milk
The study aims to recruit eligible participants and conduct interviews, collect human milk samples, and conduct laboratory analysis of persistent organic pollutants' levels in human milk samples.
- Trial name
- NCT04102085
- Testing
- no intervention
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Exposure to Environmental Pollution
Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort
Objectives and hypothesis The scale and diversity of chemicals in worldwide use today is vast. Many of these chemicals are released into the environment where they are found in air, water, soil, house dust, and in the food…
- Trial name
- NCT03084445
- Where
- 3 sites in Israel
- Volunteers
- 2,394 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Obesity
Adipose Tissue Pre and Post Bariatric Surgery
Published data suggest that inflammation and fibrosis of adipose tissue could be factors favoring the development of insulin resistance in obese individuals and that a decrease in the activity of the AMP-activity kinase protein…
- Trial name
- ETAPP (NCT05304325)
- Testing
- Bariatric surgery, Blood sampling, Blood pressure
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Breast Cancer
Persistent Organic Pollutants and Breast Cancers (POPCASE)
Exposure to certain classes of chemical contaminants, including certain persistent organic pollutants (POPs) with a character of endocrine disruptors, could be one of the factors that lead to increase incidence of breast cancer…
- Trial name
- POPCASE (NCT02890095)
- Testing
- Breast cancer surgery, plastic surgery
- Where
- 3 sites in France
- Volunteers
- 769 people
- Sponsor
- Institut Cancerologie de l'Ouest
Obesity &Amp; Overweight
Organic Pollutant Build-Up in Body Fat and Stomach Tissue Linked to Obesity Levels
This study looks at whether certain environmental chemicals, called organic pollutants, build up in the body fat and stomach tissues of people with obesity who are having weight-loss (bariatric) surgery.
- Trial name
- NCT07126743
- Testing
- exposure to organic pollutant
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dong Peng
Breast Neoplasm Female
Peri-gravidic Exposure to Endocrine Disrupting Persistent Organic Pollutants
Breast cancer, the first female cancer, affects one in eight women in her lifetime. The increase and unequal distribution of its prevalence throughout the world, regardless of age and genetic factors (< 10% of cases)…
- Trial name
- SEINPOL (NCT03673150)
- Testing
- non intervention
- Where
- France
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Environmental-Pollution-Related Condition
Characterization of a Population Living in Highly Contaminated Settlement in Campania Region
some areas in the Campania region (southern Italy) have attracted media coverage in the past 15 years, and are considered a dramatic example of an extremely polluted area.
- Trial name
- SPES (NCT05976126)
- Testing
- Determination of dioxins (PCDD/Fs), polychlorinated biphenyls (PCBs) and trace elements
- Volunteers
- 4,227 people, healthy volunteers welcome
- Sponsor
- Francesca De Filippis