Type 2 DiabetesNCT05218395
Association Between Persistent Organic Pollutants and Type 2 Diabetes /Thyroid Cancer
An observational study of Type 2 Diabetes and Thyroid Cancer, run by Qianfoshan Hospital at 1 site in China.
Trial summary
Persistent organic pollutants (POPs) are a class of organic pollutants in the environment characterized by persistent, bioaccumulation, long-range transport and biological toxicity. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Type 2 Diabetes, Thyroid Cancer, Organic Pollutant
- How many people
- 900 participants
- Where
- 1 siteChina
- Study dates
- 20 Dec 2021to 30 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Study Population：18 ~ 75 years old patients of type 2 diabetes，Thyroid Cancer and control。
Who may be able to join
- Group of Type 2 diabetes patients:
- age 18 ~ 75 years old;
- type 2 diabetes patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) , HBA1C ≥7.0% and <10.5% ;
- patients signed informed consent.
- Group of Thyroid Cancer patients:
- age 18 ~ 75 years old;
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- thyroid cancer patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;
- patients who signed the informed consent form.
- Control Group:
- age 18 ~ 75 years old;
- healthy population recruited from the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;
- living in the monitoring area for more than 6 months within 12 months;
- normal thyroid function and no history of thyroid cancer were needed in the control group;
- Fasting Blood Glucose level of 0.7 mmol/l was needed in the Control Group of Type 2 diabetes Mellitus Without History of diabetes;
- patients with informed consent.
Who cannot join
- Group of Type 2 diabetes:
- pregnant, lactating women, patients with acute cardiac cerebrovascular disease; (2) patients with severe liver and Renal Impairment (related laboratory tests more than 2 times the normal) ; (3) patients with Type 1 diabetes; (4) participants in other clinical trials within 3 months; (5) patients with malignant tumors. (6) has the disease and so on serious anemia, is not suitable to carry on the patient which the blood draws the test.
- Group of Thyroid Cancer:
- patients with serious heart, liver and Kidney Diseases (related laboratory tests more than 2 times normal) ;
- patients with other malignant tumors.
- Control Group:
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- patients with serious heart, liver or kidney disease;
- patients with iodine or Thyroid hormone;
- patients with confirmed malignant tumor;
- pregnant women or those who have recently taken contraception or estrogen.
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
Xiaoling Guan
Jinan, Shandong
Xiaoling Guan, 8613356677195, gxlwho@163.com
About this study
Persistent organic pollutants (POPs) are a class of organic pollutants in the environment characterized by persistent, bioaccumulation, long-range transport and biological toxicity. Due to its widespread distribution in the environment and Lipophilicity, POPs can bioaccumulate along the food chain and eventually accumulate in the human body. There are many types of POPs, including dioxins, polychlorinated biphenyls (PCBs) , polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) . POPs is ubiquitous and Lipophilic in the environment, so the potential harm of POPs to human body has aroused wide concern. A growing number of studies have found that exposure to POPs may be associated with an increased risk of endocrine disease, particularly type 2 diabetes and thyroid cancer.
The aim of this study was to assess the effect of Persistent organic pollutant exposure on the development ofType 2 diabetes and thyroid cancer by analyzing serum Persistent organic pollutant concentrations in controls, and patients with Type 2 diabetes and thyroid cancer.
- Conditions
- Type 2 Diabetes, Thyroid Cancer, Organic Pollutant
- Medical subject headings
- Diabetes Mellitus, Type 2, Thyroid Neoplasms
What is being measured
The primary outcome is the main question the study is designed to answer.
To assess the risk of Persistent organic pollutant exposure to type 2 diabetes
to explore the effect of Persistent organic pollutant on the risk of type 2diabetes
Measured: 2021．11 Ethics Committee Approval 2021.12-2024.12 controls/patients recruitment, samples test 2025.1-2024.12 data analysis
Secondary outcomes (1)
To assess the risk of Persistent organic pollutant exposure to thyroid cancer
to explore the effect of Persistent organic pollutant on the risk of thyroid cancer
Measured: 2021．11 Ethics Committee Approval 2021.12-2024.12 controls/patients recruitment, samples test 2025.1-2024.12 data analysis
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Feb 2022
- Study start20 Dec 2021
- Primary completion29 Dec 2024 (estimated)
- Study completion30 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Type 2 DiabetesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 900 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Qianfoshan Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Chinese Academy of Sciences
- Responsible party
- Sponsor
- Investigators
- Xiaoling Guan, Principal investigator, Qianfoshan Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05218395
- Sponsor's protocol ID
- YXLL-KY-2021(064)
- Status last verified
- Feb 2022
- First submitted
- 20 Jan 2022
- Last updated
- 24 Feb 2022
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Persistent Organic Pollutants and Type 2 Diabetes /Thyroid Cancer
- ClinicalTrials.gov ID
- NCT05218395
- Acronym / sponsor ID
- YXLL-KY-2021(064)
- Conditions
- Type 2 Diabetes, Thyroid Cancer, Organic Pollutant
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 900 participants (estimated)
- Lead sponsor
- Qianfoshan HospitalUniversity, hospital or other
- Collaborators
- Chinese Academy of Sciences
- Study start
- 20 Dec 2021 (actual)
- Primary completion
- 29 Dec 2024 (estimated)
- Study completion
- 30 Dec 2025 (estimated)
- First posted
- 1 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Persistent organic pollutants (POPs) are a class of organic pollutants in the environment characterized by persistent, bioaccumulation, long-range transport and biological toxicity. Due to its widespread distribution in the environment and Lipophilicity, POPs can bioaccumulate along the food chain and eventually accumulate in the human body. There are many types of POPs, including dioxins, polychlorinated biphenyls (PCBs) , polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) . POPs is ubiquitous and Lipophilic in the environment, so the potential harm of POPs to human body has aroused wide concern. A growing number of studies have found that exposure to POPs may be associated with an increased risk of endocrine disease, particularly type 2 diabetes and thyroid cancer.
The aim of this study was to assess the effect of Persistent organic pollutant exposure on the development ofType 2 diabetes and thyroid cancer by analyzing serum Persistent organic pollutant concentrations in controls, and patients with Type 2 diabetes and thyroid cancer.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Study Population：18 ~ 75 years old patients of type 2 diabetes，Thyroid Cancer and control。
Key inclusion criteria (15 listed)
- age 18 ~ 75 years old;
- type 2 diabetes patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) , HBA1C ≥7.0% and <10.5% ;
- patients signed informed consent.
- age 18 ~ 75 years old;
- thyroid cancer patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;
Key exclusion criteria (10 listed)
- Group of Type 2 diabetes:
- patients with serious heart, liver and Kidney Diseases (related laboratory tests more than 2 times normal) ;
- patients with other malignant tumors.
- patients with serious heart, liver or kidney disease;
- patients with iodine or Thyroid hormone;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
To assess the risk of Persistent organic pollutant exposure to type 2 diabetes
Time frame: 2021．11 Ethics Committee Approval 2021.12-2024.12 controls/patients recruitment, samples test 2025.1-2024.12 data analysis
to explore the effect of Persistent organic pollutant on the risk of type 2diabetes
1 secondary outcome
To assess the risk of Persistent organic pollutant exposure to thyroid cancer
Time frame: 2021．11 Ethics Committee Approval 2021.12-2024.12 controls/patients recruitment, samples test 2025.1-2024.12 data analysis
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2022.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Xiaoling Guan principal investigator
Qianfoshan Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Type 2 Diabetes and Thyroid Cancer, run by Qianfoshan Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 15 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 24 Feb 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Xiaoling Guan (8613356677195, gxlwho@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To assess the risk of Persistent organic pollutant exposure to type 2 diabetes (time frame: 2021．11 Ethics Committee Approval 2021.12-2024.12 controls/patients recruitment, samples test 2025.1-2024.12 data analysis). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2022; AzTrials last refreshed its copy on 29 Oct 2026.