Clinical trials: Organophosphate Poisoning
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Disorders of Environmental Origin
Reducing Pesticide Exposure in Minority Families
This is a community-based participatory research program focusing on pesticide contamination in migrant farmworker families.
- Trial name
- NCT00014807
- Testing
- Reducing Pesticide Exposure in Minority Families
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Organophosphate Poisoning
To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning
To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Objectives: To study the effect of administration of intravenous lipid emulsion on hemodynamic parameters, incidence of adverse effects…
- Trial name
- NCT03564574
- Testing
- Lipid Emulsion
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Organophosphorus Poisoning
Fresh Frozen Plasma Transfusion in Acute Organophosphate Poisoning
this study clinical trial to assess the role of fresh frozen plasma as a novel available and easy to be applied rather than conventional therapy on organophosphate poisoned patients and prediction of it is prognosis on selected…
- Trial name
- NCT06256796
- Testing
- fresh frozen plasma
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Organophosphate Poisoning
A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning
Organophosphate pesticide poisoning causes close to 300 000 deaths per year worldwide. Many patients who ingest organophosphates require ventilation; of these patients approximately 50% die.
- Trial name
- NCT02147054
- Testing
- Rocuronium, Sugammadex
- Where
- Sri Lanka
- Volunteers
- 45 people
- Sponsor
- University of Edinburgh
Organophosphate Poisoning
The Use of Self-reported Symptoms as a Proxy for Acute Organophosphate Poisoning Among Nepali Farmers
The purpose of this study is to evaluate self-reported symptoms as a proxy for acute organophosphate poisoning by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational…
- Trial name
- NCT02838303
- Testing
- Organophosphate
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Organophosphorus Poisoning
Role of Intralipid in Management of Organophosphorus Poisoning
Aim of the study: To assess the role of intralipid emulsion in the acute man-agement of organophosphorus toxicity and its benefits in de-creasing mortality rates among victims.
- Trial name
- NCT04393103
- Testing
- Intralipid, 20% Intravenous Emulsion, Intravenous Atropine Sulfate
- Sponsor
- Amani Hassan Abdel-Wahab
Organophosphorus Poisoning
A Study of Inhaled Atropine Sulfate in Healthy Adults
MicroDose Defense Products, LLC is developing an atropine dry powder inhaler (ADPI). This pilot study compares the pharmacokinetics (PK) of inhaled dry powder atropine as delivered by the ADPI to atropine delivery from the…
- Trial name
- NCT00947596
- Testing
- atropine sulfate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- MicroDose Defense Products L.L.C.
Neurotoxicity Syndromes
Scopolamine Treatment for Patients With Organophosphate Poisoning
Organophosphate (OP) compounds are a major threat as chemical warfare agents or in terrorist act. OPs are also the active ingredient of many insecticides.
- Trial name
- NCT00389259
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Poisoning
Community Based Prevention/Control Project
This project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced.
- Trial name
- NCT00013767
- Testing
- Individual and Community education
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Rivastigmine Toxicity
A Double-Blind, Placebo-controlled Crossover Study of Repeat Rivastigmine Administration in Healthy Male Volunteers
Rivastigmine is a carbamate, approved by the FDA for the treatment of mild to moderate dementia associated with Alzheimer's and Parkinson's diseases.
- Trial name
- RIVA-1 (NCT00624663)
- Testing
- Rivastigmine
- Where
- 2 sites in Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Organophosphate Poisoning
Magnesium Sulphate With Atropine and Pralidoxime vs Standard Therapy Alone in Acute Organophosphate Poisoning
Pakistan, being a developing country, is one of the regions with the most cases of organophosphate (OP) poisoning/toxicity. MgSO4 is one of the most promising adjunctive treatments that needs to be tested.
- Trial name
- NCT07777835
- Testing
- Atropine plus pralidoxime, Atropine and pralidoxime with adjunctive MgSO4
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Muhammad Aamir Latif
Organophosphate Poisoning
Adding Nebulized Salbutamol to Intravenous Atropine and Oxygen in OP Poisoning
We hypothesize that salbutamol will speed removal of alveolar fluid compared to atropine alone in OP poisoned patients. We propose to compare the effect of two stat doses of nebulized salbutamol (2.5 mg; 5.0 mg), with nebulized…
- Trial name
- SalbutamolOP (NCT02160548)
- Testing
- Standard care, Standard care+ 2.5 mg Salbutamol, Standard care+ 5 mg Salbutamol
- Where
- Bangladesh
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Organophosphate Poisoning
Paraoxonase-1 Pseudo Cholinesterase Organophosphate Toxicity Enzyme in Prediction the Severity and Outcome of Acute Organophosphate Poisoning and Its Correlation With Pseudo Cholinesterase Enzyme Level.
The aim of the present study is to: Evaluate the serum Paraoxonase-1 level in cases with organophosphate compounds poisoning and to correlate it᾿s level with the severity, outcome of acutely organophosphate poisoned cases .
- Trial name
- NCT06108557
- Testing
- Serum Pararoxonase -1 level, Diagnostic Test: Serum pseudocholinesterase enzyme level
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Organophosphorus Poisoning
Outcome of Moderate Severity in OPC Poisoning Patients When Treated With Pralidoxime
This open level randomized controlled trial will be conducted in the department of medicine at Sir Salimullah Medical College and Mitford Hospital.
- Trial name
- OPC (NCT06111352)
- Testing
- Pralidoxime, Atropine
- Where
- Bangladesh
- Volunteers
- 96 people
- Sponsor
- Sir Salimullah Medical College Mitford Hospital
Poisoning
Pesticide Exposure Pathways for Farmworker Children
This project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced.
- Trial name
- NCT00013754
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Medical Countermeasures, Organophosphate Poisoning
A Study to Evaluate the Intramuscular Administration of Scopolamine
To characterize the safety and tolerability profile of ascending doses of scopolamine hydrobromide trihydrate (Scopolamine HBT) administered by intramuscular (IM) injection.
- Trial name
- NCT04314713
- Testing
- Scopolamine Hydrobromide Trihydrate
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Organophosphate Poisoning
Farming, Personal Protective Equipment, Nepal
According to the World Health Organization pesticide poisoning is a major health problem due to the millions of cases annually occurring worldwide.
- Trial name
- NCT02137317
- Testing
- LAPPE (locally adapted personal protective equipment)
- Where
- Nepal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Acute Organophosphorus Pesticide Poisoning
Study to Know the Efficacy of Higher Doses of Pralidoxime in Patients of Organophpsphorus Poisoning.
The purpose of this study is to determine whether high doses of pralidoxime(PAM) are effective as compare to lower doses of PAM in the management of moderately sever organophosphorus poisoning patients.
- Trial name
- NCT00333944
- Testing
- Pralidoxime(drug)
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Giriraj Hospital