Clinical trials: Orthopedic Patients
Open Fracture
Preventing Infections in Orthopaedic Patients
Determine if antibiotic prophylaxis with intravenous cephalosporin and aminoglycoside in patients with Type II and II open fractures is safe and effective.
- Trial name
- NCT02948387
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Olayemi Osiyemi MD
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery
One technique for the nerve block involves injecting the numbing medicine where the nerve is together (higher up in the back of the thigh).
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot
- Trial name
- NCT01550094
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Acute Pain, Fractures
Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
Opioid pain medications such as morphine and dilaudid are commonly used in emergency departments to treat pain in patients. Physicians are familiar with the side effects of these medications; the most concerning of which is…
- Trial name
- NCT02430818
- Testing
- ketamine, morphine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Staphylococcal Infections, Joint Prosthesis
StaphVAX Immunogenicity in Orthopedic Implant Patients
S. aureus is the most common pathogen involved in prosthetic joint infection. StaphVAX® is a vaccine to prevent these infections, which conjugates the purified capsular polysaccharides of S. aureus to a carrier protein.
- Trial name
- NCT00211926
- Testing
- S. aureus Type 5 & 8 Capsular Polysaccharide Conjugate
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nabi Biopharmaceuticals
Orthopedic Disorder
Effect of Preoperative Education Based on Roy Adaptation Model
This research was conducted as a randomized controlled experiment to determine the effect of the education given by the Physiological Mode of Roy Adaptation Model in patients with hip or knee arthroplasty on physical adaptation…
- Trial name
- NCT05248529
- Testing
- Education booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Post-operative Pain
Comparing Perioperative Outcomes in Pain Control
This project consists of a randomized controlled study design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have an orthopaedic injury requiring surgery.
- Trial name
- NCT05690282
- Testing
- Multimodal Pain Management (Ibuprofen/Acetaminophen/GABAPentin/0.25%Bupivacaine)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Constipation, Perioperative Nursing
Effect of a Constipation Prevention Checklist in Hip Surgery Patients
Constipation is a common postoperative problem in patients undergoing hip surgery and may be associated with immobilization, opioid analgesic use, and inadequate fluid and fiber intake.
- Conditions
- Constipation, Perioperative Nursing, Checklist, Orthopedic Disorder
- Trial name
- NCT07895316
- Testing
- Constipation prevention and checklist monitoring in hip surgery patients
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Anemia
Non-invasive Identification of Preoperative Anaemia
Approximately 20% of patients undergoing elective orthopaedic surgery are anaemic. When not identified and treated before surgery, this can lead to requiring blood transfusions, which brings additional expenses, time and…
- Trial name
- NIPPA (NCT04247178)
- Where
- United Kingdom
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Patient Satisfaction
The Effect of Smartphone-Based Recording Offer on Patient Satisfaction in Orthopedic Care
The purpose of this study is to determine patient satisfaction with orthopedic preoperative encounter based on offer to record the encounter on patient personal smartphone.
- Trial name
- NCT06998212
- Testing
- Offer to record encounter
- Where
- United States
- Volunteers
- 972 people, healthy volunteers welcome
- Sponsor
- Blake Han
EEG Data Analysis, Orthopedic Surgery
Characteristic Electroencephalogram of General Anesthesia
Patients were enrolled according to predefined inclusion and exclusion criteria. Following surgical admission, standard monitoring was initiated, including continuous assessment of heart rate, blood pressure, electrocardiogram…
- Trial name
- NCT07468162
- Testing
- After the use of sedative drugs, the changes in the electroencephalogram (EEG) spectrum were observed with an EEG monitor
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Staphylococcal Infections
Bacterial Phenotype of Staphylococcus Aureus Has no Effect on Patients' Clinical Outcome in Orthopedic Device Related Bone Infections
This was a prospective study performed between November 2011 and September 2013. Patients with a confirmed S. aureus infection after fracture fixation or prosthetic joint infection were included.
- Trial name
- StaphType (NCT02971657)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- BG Unfallklinik Murnau
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Orthopedic Disorder
Motor Imagery and Rehabilitation of Orthopaedic Patients
Motor imagery is increasingly used as a plasticity-booster to complement conventional rehabilitation. Here the investigators test the hypothesis that the combination of mental training with conventional rehabilitation may speed…
- Trial name
- NCT03370146
- Testing
- Mental training based on Motor Imagery, Cognitive training, Evaluation of gait abilities
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Post Spinal Anaesthesia Hypotension, Geriatric Population
Effect of Dexamethasone on Post-spinal Hypotension
The goal of this clinical trial is to learn if intravenous dexamethasone is effective for prevention of post spinal hypotension in geriatric population undergoing orthopedic surgeries.
- Conditions
- Post Spinal Anaesthesia Hypotension, Geriatric Population, Orthopedic Surgeries
- Trial name
- NCT06819436
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Sarcoma, Bone, Sarcoma, Soft Tissue
Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients
The goal of DEEPGAIT study is to determine how serious walking problems are for pediatric cancer patients who have had orthopedic surgery, how they change over time, and what can be done to help.
- Conditions
- Sarcoma, Bone, Sarcoma, Soft Tissue, Gait Disorder
- Trial name
- NCT07502885
- Testing
- Lab based 3D Gait Assessment, Wearable Inertial Sensors (In Lab and Remote), Functional Testing & Patient Reported Outcomes
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Arthropathy of Knee, Arthropathy of Hip
Nirvana Super Pro Supplementation in Orthopedic Surgery Patients
The purpose of this study is to investigate orthopedic patients undergoing either a total hip replacement (THR) or total knee arthroplasty (TKR) using two dietary supplements, PREPARE and RECOVER, and their recovery times…
- Trial name
- NCT06203691
- Testing
- Supplementation with Nirvana Super Pro Liquid Supplements, Non-Supplementation Group
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nirvana Water Sciences Corp
Osteoporotic Fractures
Training of Orthopedic Residents in OP Treatment
Objective: To assess whether residents (R1, R2 or R3 according to the year of residency) of an orthopedic tertiary service, investigate, treat and / or refer the patient with an osteoporotic fracture to treat osteoporosis (OP)…
- Trial name
- NCT04911946
- Testing
- Questionnaire
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Quality of Life, Surgery
Determination of the Effect of Puzzle Use in Elderly Patients
The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and…
- Conditions
- Quality of Life, Surgery, Postoperative Confusion, Cognitive Dysfunction
- Trial name
- NCT05796830
- Testing
- Puzzle application
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Patient-controlled Sedation
Patient-controlled Sedation Versus Target-controlled Infusion in Orthopaedic Surgery Under Central Neuraxial Block
Orthopaedic surgeries involving the legs can be done under nerve block, where patients will be numb of pain at the operated site but awake during surgery.
- Trial name
- NCT03647735
- Testing
- patient-controlled sedation
- Where
- Malaysia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Knee Arthroplasty
First Mobilization Protocol for Total Knee Arthroplasty Patients
This single blinded randomized controlled study evaluates the effect of developed First Mobilization Protocol applied to knee arthroplasty patients on state anxiety, kinesiophobia, initial mobilization related symptoms.
- Trial name
- NCT06268899
- Testing
- First mobilization protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gazi University