Clinical trials: Orthostatic Hypotension
Neurogenic Orthostatic Hypotension
Controlled CO2 Inhalation in NOH
This study focuses on neurogenic orthostatic hypotension (nOH), which is a disorder characterized by an abnormal drop in blood pressure (BP) within 3-minutes of standing.
- Trial name
- CO2-nOH (NCT06751888)
- Testing
- Controlled CO2 delivery
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Calgary
Healthy Controls Without Orthostatic Hypotension
Cognitive Changes in Mild Cognitive Impairment
Background: In recent years, the changes of cognitive function in mild cognitive impairment have attracted attention. Methods/design: We will follow up at 3.
- Trial name
- NCT05821400
- Testing
- observational study
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fujian Medical University Union Hospital
Orthostatic Hypotension
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal…
- Trial name
- NCT05960448
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Orthostatic Intolerance, Syncope
Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension
This study is aimed primarily at providing a simple and effective form of treatment to reduce the symptoms of Initial Orthostatic Hypotension (IOH) and prevent syncope.
- Conditions
- Orthostatic Intolerance, Syncope, Fainting, Presyncope
- Trial name
- IOH (NCT03970551)
- Testing
- Physical Counter-maneuver, Stress Test, Functional Electrical Stimulation
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Orthostatic Hypotension
Evaluation of the Contribution of Lower Limb and/or Abdominal Compression on Orthostatic Hypotension
Orthostatic hypotension (OH) is associated with an increased risk of myocardial infarction, stroke, heart failure and neurocognitive disorders. In the elderly, OH is an independent predictor of falls and mortality.
- Trial name
- HYPOFLEX (NCT06694688)
- Testing
- the supine/standing postural change test
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Gérond'if
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Chronic Fatigue Syndrome
The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS), otherwise known as Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME), is an under-recognized disorder whose cause is not yet understood.
- Conditions
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Exercise Intolerance
- Trial name
- NCT03674541
- Testing
- Pyridostigmine Bromide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brigham and Women's Hospital
Orthostatic Hypotension, Syncope
The Effect of Water Carbonation on Orthostatic Tolerance
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers.
- Conditions
- Orthostatic Hypotension, Syncope, Vasovagal Syncope
- Trial name
- NCT05621460
- Testing
- 500mL carbonated water, 500mL still water, 50mL still water
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Ischemic Stroke, Haemorrhagic Stroke
The Effects of Posture on Cerebral Blood Flow Velocity During the Acute Phase of Stroke
After stroke, blood vessels in the brain can become damaged, and the brain's ability to control blood flow can be impaired. The brain therefore may be less able to maintain a healthy level of blood flow during challenges such as…
- Conditions
- Ischemic Stroke, Haemorrhagic Stroke, Cerebrovascular Accident, Acute Stroke
- Trial name
- NCT04972812
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Sheffield Hallam University
Parkinson Disease, Multiple System Atrophy, Parkinson Variant
Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes
The purpose of the present clinical trial is to determine whether the use of an elastic abdominal binder is effective in the non-pharmacological management of symptomatic, neurogenic orthostatic hypotension (OH) in individuals…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Orthostatic; Hypotension, Neurogenic
- Trial name
- ABOH-PS (NCT04920552)
- Testing
- Elastic abdominal binder
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Universitätsklinik für Neurologie, Innsbruck
Spinal Cord Injuries, Cardiovascular Diseases
Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury
The aim of this study is to examine the mechanisms of transcutaneous spinal cord stimulation (tSCS) for improving cardiovascular and pulmonary function in individuals with chronic motor-complete spinal cord injury (SCI) by…
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Cardiopulmonary Diseases
- Trial name
- NCT06379711
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Hypotension, Postural
Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI
Due to de-centralized cardiovascular control, persons with spinal cord injury (SCI) experience blood pressure (BP) dysregulation which manifests in chronic hypotension with exacerbation during orthostatic positioning.
- Trial name
- NCT02307526
- Testing
- Pyridostigmine Bromide, Tilt table test
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Post-Exercise Hypotension
Resistance Exercise Modify Cardiovascular Responses of Professors During Teaching and Sleep
Both work activity and reduced nocturnal dipping of blood pressure are related to increased cardiovascular risk. The aim of the present study was to assess the hemodynamic and autonomic responses of university professors during…
- Trial name
- NCT02650089
- Testing
- Resistance Exercise Low intensity, Resistance Exercise High intensity, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Autonomic Nervous System Diseases, Orthostatic Hypotension
Treatment of Orthostatic Hypotension
The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system.
- Conditions
- Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
- Trial name
- NCT00581477
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Trauma, Nervous System, Nervous System Diseases
- Trial name
- SCI (NCT05731986)
- Testing
- Orthostatic challenge, Biostim-5 transcutaneous spinal stimulation - Mapping, Biostim-5 transcutaneous spinal stimulation - "Optimal" testing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Orthostatic Intolerance, Orthostatic Hypotension
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty in Patients Receiving ACEIs and ARBs
Incidence and pathophysiologic hemodynamics of postoperative orthostatic intolerance and orthostatic hypotension in patients receiving antihypertensives
- Trial name
- NCT04842058
- Testing
- Mobilisation procedure
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Hvidovre University Hospital
Spinal Cord Injuries
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in participants with chronic cervical or high-thoracic spinal cord…
- Trial name
- HEMO (NCT05044923)
- Testing
- Targeted Epidural Spinal Stimulation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Aaron Phillips
Hypotension, Orthostatic, Total Hip Replacement
Study on Baroreceptor Function in Relation to Orthostatic Blood Pressure Regulation After Hip Surgery
The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty.
- Trial name
- NCT01866787
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease
A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy
Evaluate the clinical efficacy and safety of droxidopa versus placebo over a 17 week (maximum) treatment period in patients with symptomatic NOH.
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease, Multiple Systems Atrophy, Pure Autonomic Failure
- Trial name
- NCT01927055
- Testing
- Droxidopa
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- Chelsea Therapeutics
Hypotension, Orthostatic, Parkinson Disease
Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease
Study on orthostatic Hypotension in Parkinson's disease
- Conditions
- Hypotension, Orthostatic, Parkinson Disease, Autonomic Failure, Cognitive Impairment
- Trial name
- PaKogOH (NCT03900000)
- Testing
- Physiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- RWTH Aachen University
Autonomic Failure, Pure Autonomic Failure
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT02897063
- Testing
- Droxidopa, Midodrine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Vanderbilt University Medical Center