Clinical trials: Orthotopic Heart Transplantation
Congenital Disorders
Pulmonary Resistance in Fontan Who Have Undergone Heart Transplantation
Clinical evidence reveals that some patients who undergo cardiac transplantation exhibit problems with pulmonary vascular resistance as well.
- Trial name
- NCT00268047
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Healthcare of Atlanta
Pulmonary Arterial Hypertension
Nitric Oxide, GeNO Nitrosyl Delivery System
The primary aim of the study is to evaluate the safety, tolerability and device performance of the GeNO nitrosyl delivery system during RHC.
- Trial name
- NCT01165047
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Transthyretin Cardiac Amyloidosis
Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With Transthyretin-mediated Amyloidosis Post Orthotopic Heart Transplantation
Transthyretin cardiac amyloidosis (ATTR-CA) is a relentlessly progressive disease that can progress to end stage heart failure, at which point recently approved transthyretin production silencing or structure stabilizing…
- Trial name
- NCT05489523
- Testing
- Tafamidis 61 MG
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Patients With Post Orthotopic Heart Transplantation Status
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation.
The primary purpose of this study is to measure the level of an enzyme in a patient's heart called inducible nitric oxide synthase(iNOS) using Positron Emission Tomography (PET) imaging with a radioactive tracer called 18F-NOS.
- Trial name
- F-NOS (NCT01066637)
- Testing
- [18F](+/-)NOS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Heart Transplantation
Remote Ischemic Preconditioning and Acute Kidney Injury in HTX
Postoperative Acute Kidney Injury (AKI) is a common complication after heart transplantation (HTX) affecting outcome of patients.
- Trial name
- RIPCAT (NCT05364333)
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Orthotopic Heart Transplantation
Impact of Race and Re-Transplantation
For children who develop graft failure following cardiac transplantation, retransplantation is often considered. While some centers have reported equivalent results for retransplantation as compared to primary transplantation…
- Trial name
- NCT00229788
- Where
- United States
- Sponsor
- Children's Healthcare of Atlanta
Liver Transplantation
Hemodynamic Measurements During Liver Transplantation
The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.
- Trial name
- OLT (NCT00682110)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Orthotopic Heart Transplantation, Graft Failure
Terminal Graft Failure
One of the risks associated with heart transplantation is failure of the graft. A graft is where the new heart is attached to the original vessels in the body.
- Trial name
- NCT00208884
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Emory University
Orthotopic Heart Transplant
Coronary Artery Vasculopathy in Pediatric Heart Transplant Patients
Heart transplantation is a life-sustaining therapy that allows patients with either congenital or acquired heart disease and severe cardiac dysfunction to survive. Over time, however, the transplanted heart can develop problems.
- Trial name
- CFR-OHT (NCT03231371)
- Testing
- Adenosine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Bryan Goldstein
Congenital Abnormalities, Pulmonary Arterial Hypertension (PAH)
Safety and Effectiveness of a Virtual Pediatric Cardiac Rehabilitation Program or Telerehabilitation in Children With Heart Disease
Cardiac telerehabilitation is a much-needed pediatric therapy; however, a lack of randomized controlled trials has limited the development of and reimbursement for this valuable service.
- Conditions
- Congenital Abnormalities, Pulmonary Arterial Hypertension (PAH), Orthotopic Heart Transplant, Cardiac Rehabilitation
- Trial name
- NCT06819059
- Testing
- Pediatric Cardiac Telerehabilitation, Fitness Tracker Only
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Children With Heart Transplants
Tissue Doppler Echo Imaging of Heart Function After Transplant
There are many children born with Congenital Heart Disease. Many of these children have to undergo surgical procedures to correct the problem. Some patients must eventually get a new heart.
- Trial name
- NCT00208650
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Emory University
Cardiac Transplantation, Cardiopulmonary Bypass
Intraoperative Use of Extracorporeal Cytokine Adsorption During Orthotopic Heart Transplantation
There are several factors initiating cytokine storm and dysregulated systemic inflammatory response during cardiac transplantation.
- Trial name
- NCT03145441
- Testing
- CytoSorb®
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Semmelweis University
Liver Transplant Disorder, Reperfusion Injury
Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation
Researchers are trying to improve the understanding of systolic function of the heart at the time of liver reperfusion in patients undergoing orthotopic liver transplantation.
- Trial name
- NCT04316468
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Hepatitis C, Heart Transplant
Expanding the Pool in Orthotopic Heart Transplantation
This is an open-label, pilot trial to test the safety and efficacy of transplantation of hearts from HCV seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on…
- Conditions
- Hepatitis C, Heart Transplant, Cardiac Transplant
- Trial name
- NCT03222531
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mary E. Keebler, MD
Orthotopic Heart Transplant
Motivational Interviewing and Group Heart Transplant Exercise and Education: A Pilot Study
The aim of this 16-week group aerobic training program, delivered remotely via video-conferencing, is to assess program feasibility, and determine if program increases physical activity in adolescents after heart transplant.
- Trial name
- MIGHTEE (NCT05398744)
- Testing
- Group Exercise Program
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Heart Transplant Patients
Scanner and Transplant Heart Patients Protocol
Coronary vasculopathy remains the leading cause of decreased survival after the first year post-transplantation. It is mainly asymptomatic because of the denervation of the heart transplant.
- Trial name
- NCT01122810
- Testing
- Coronary scanner
- Where
- France
- Volunteers
- 102 people
- Sponsor
- French Cardiology Society
Liver Transplant; Complications, Cardiovascular Complication
Cardiovascular Outcomes in Orthotopic Liver Transplanted Patients (COLT Study)
All patients with orthotopic liver transplantation who are evaluated and followed at each participating centers will be recorded in this study. Within this register a characterization of patients and therapy will be done.
- Conditions
- Liver Transplant; Complications, Cardiovascular Complication, Cardiovascular; Attack, Cardiovascular Stroke
- Trial name
- COLT (NCT05895669)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Children Who Underwent Heart Transplantation Prior to Age 18, Received Care at Children's Healthcare of Atlanta
Allograft Fibrosis Following Pediatric Cardiac Transplantation
Transplantation is the preferred method of treating many forms of end-stage organ failure. While short-term results have improved, long-term outcomes remain inadequate.
- Trial name
- NCT00328185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Healthcare of Atlanta
Heart Transplant Failure and Rejection, Coronary Artery Disease
Percutaneous Coronary Intervention in Patients witH OrthotoPic hEart Transplantation: the PCI-HOPE a Multicenter Study.
This is a retrospective, multicenter, study including patients undergone to one or more percutaneous revascularization after OHT.
- Trial name
- PCI-HOPE (NCT03538509)
- Testing
- PCI and implantation drug eluting stent or bare metal stent
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fabrizio D'Ascenzo